BackgroundAlthough comprehensive approaches to student health promotion through wellness policy implementation show potential for scale-up, scant empirical research has been conducted to meaningfully integrate dissemination and implementation (D&I) in evaluation procedures. Such application is necessary to understand how and why interventions are sustained over time. The aims of this study were to investigate: 1) implementation determinants of adoption, fidelity, and penetration for school-wide wellness programming; and 2) nuanced determinants between schools with prior experience and those new to the program, to enhance tailored implementation support and sustainability.MethodsThe School Wellness Integration Targeting Child Health (SWITCH®) capacity-building intervention was adopted in 52 elementary and middle (22 new; 30 experienced) schools across Iowa, United States in the 2019–2020 academic year. The Consolidated Framework for Implementation Research (CFIR) guided development of mixed methods data collection and analysis protocols, adapted to school settings. Determinants from CFIR were linked to three key implementation outcomes: 1) fidelity/compliance to established quality elements; 2) adoption of best practices in multiple settings; and 3) penetration of behavior change practices across classrooms and grade levels. Organizational readiness/capacity was also assessed at baseline. Interview data were scored using a systematic process; each CFIR domain was assigned a score (ranging between -2 and +2) to denote either a positive or negative influence on implementation. Independent t-tests were conducted to capture potential differences between new and experienced schools, followed by Pearson bivariate correlation analyses to determine relationships between CFIR determinants and implementation outcomes. ResultsIn experienced schools, fidelity/compliance (t=-1.86 p=.07) and adoption (t=-2.03 p=.04) were slightly higher than new schools. The CFIR determinants of innovation source, culture and relative priority, and leadership engagement were positively related to implementation outcomes, whereas tension for change and networks and communications were observed negative determinants. Unique negative determinants for new schools comprised relative advantage, engaging key stakeholders, and reflecting/evaluating, among others. ConclusionsFindings provide specific areas of need where implementation support may be most valuable, especially for new schools undertaking a comprehensive program such as SWITCH. Tailoring implementation support to both new and existing settings will ultimately enhance dissemination and sustainability of evidence-based interventions.