Gypsum-salt caprock is one of the most important caprocks in petroliferous basins around the world. Its sealing capacity extremely affects hydrocarbon accumulation and distribution. However, there are numerous variables that affect caprock sealing performance, making a quantitative evaluation challenging. The analytic hierarchy process (AHP), which has the advantage of turning several influencing factors into multi-level single objectives, can be utilized in this context to quantify the weight of each element impacting caprock sealing capacity. As a result, using the Tarim Basin’s Cambrian as an example, this article quantitatively assessed the gypsum-salt caprock sealing capacity using AHP. The results show that factors affecting the sealing capacity of Cambrian gypsum-salt caprock in the Tarim Basin can be summarized into three major categories and nine sub-categories, including the lithology (rock assemblage type and lithology zoning), the thickness (total thickness of thick single layer, maximum thickness of thick single layer, total thickness, and ratio of caprock to stratum), and the mechanical properties (internal friction coefficient, compressive strength, peak strength). The sealing ability evaluation index (C) was created by applying AHP to quantify a number of different characteristics. The capacity of the caprock to seal is inversely correlated with the C-value. The value of C in the plane climbs consistently from Tabei to Tazhong and subsequently to the Bachu region, indicating a steady improvement in caprock sealing ability. Additionally, the evaluation’s findings are in line with how hydrocarbon accumulations are currently distributed. Furthermore, hydrocarbons are mostly distributed in subsalt and subsalt-dominated layers when C is greater than 2. On the contrary, hydrocarbons are mainly distributed in post-salt layers when C is less than 2. Furthermore, in areas affected by faults, hydrocarbons are favorably distributed in subsalt layers when C reaches 2, and fault activity is poor or strong in the early period and weak in the late period.
