Evaluating the Protective Role of Ginseng against Histological and Biochemical Changes Induced by Aflatoxin B1 in the Renal Convoluted Tubules of Adult Male Albino Rats

Zidan, Rania A.; Elnegris, Heba M.; Wahdan, Rania A.

doi:10.4172/2161-0681.1000253

Cited by 5 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Peroxidation of lipids is evident in the renal brush border and dramatically changes the properties of the biological membranes leading to severe cell injury with loss of its apical brushing (Adewole et al, 2007, Al-Yahya et al, 2013) . Ginseng markedly improve these changes which was in the same line with others who suggested that ginseng had a protective effect through protection of cells and tissues from the destructive effects of the free radicals (Zidan RA, 2015) . This effect could be also attributed to the previously mentioned lipid peroxidation inhibitory effect of ginseng (Zhang et al, 2010) .…”

Section: Discussionsupporting

confidence: 87%

“…Rats were equally and randomly divided into 4 groups (8 rats for each group): Control Group (C-group): received standard rat chow diet and clean water. Ginseng Group (G-group): received 100 mg/kg of ginseng daily in a single dose dissolved in 100 ml distilled water by oral gavage for 12 weeks (Zidan RA, 2015) . Omeprazole Group (OM-group): received 20 mg/kg omeprazole daily in a single dose dissolved in distilled water by an oral gavage for 12 weeks (Shah et al, 2016) . Omeprazole-Ginseng Group (OM-G group): received a daily dose of ginseng (100 mg/kg/day) and omeprazole (20 mg/kg body weight/day) both dissolved in distilled water and given simultaneously by an oral gavage for 12 weeks. …”

Section: Methodsmentioning

confidence: 99%

“…Ginseng Group (G-group): received 100 mg/kg of ginseng daily in a single dose dissolved in 100 ml distilled water by oral gavage for 12 weeks (Zidan RA, 2015) .…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Ginseng Ameliorates Effect of Prolonged Use of Omeprazole in Rat Renal Cortex through Decreasing Inflammation, Fibrosis and Apoptosis

Dayem

Saied

Ali³

et al. 2020

Preprint

View full text Add to dashboard Cite

Omeprazole is used in acid-related gastrointestinal disorders but has prolonged usage adverse effects. The aim was to study changes in renal cortex following chronic Omeprazole administration and the possible protective role of ginseng. Rats were divided into control (C-), Ginseng (G-), omeprazole (OM-), and omeprazole-ginseng (OM-G) groups. Serum urea and creatinine levels and 24-hours urine-protein were determined. Kidneys were processed for histological study. Serum urea and creatinine and 24-hours protein were significantly higher in OM-group compared to controls and significantly decreased in OM-G group comparing to OM-group. OM-group showed significant glomerular and tubulointerstitial injury with vascular congestion, inflammatory cell infiltration, partial or complete damage of apical brush border of most tubules, interrupted basement membranes of glomerular capillaries and tubules, marked increase in collagen deposition, and significant increases in COX-2 and caspase-3 immune-expression. Co-administration of ginseng with omeprazole resulted in marked and significant improvement of these morphological changes. Conclusion: Omeprazole induced renal functional and morphological changes through inflammatory reaction, induction of fibrosis, cellular degeneration and apoptosis. Coadministration of ginseng ameliorated these effects through its anti-inflammatory, antifibrotic, and anti-apoptotic effects.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Ginseng Ameliorates Effect of Prolonged Use of Omeprazole in Rat Renal Cortex through Decreasing Inflammation, Fibrosis and Apoptosis

Dayem

Saied

Ali³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Thus changing the properties of the biological membranes Reno-protective Role of Ginseng in the Long-term Omeprazole Induced Adverse effects leads to severe cell injury leading to loss of its apical brushing (39) . Using ginseng markedly improved these changes due to that ginseng protect cells and tissues from the destructive effects of the free radicals (14) and also the lipid peroxidation inhibitory effect of ginseng (33) .…”

Section: Discussionmentioning

confidence: 99%

Reno-protective Role of Ginseng in Counteracting the Long-term Omeprazole Induced Adverse Effects in Albino Rats via Modulation of Inflammation, Apoptosis and Fibrosis

Maher

El‐Tahawy

Hussien

et al. 2023

Minia Journal of Medical Research

View full text Add to dashboard Cite

Background: Omeprazole has long-term use adverse effects even though are commonly used.The study aimed at evaluation of the possible renal protective effect of ginseng against the long-term omeprazole-induced adverse effects. Methods: Forty albino rats were divided into: C group (control), G group (ginseng), OM group (omeprazole) and OM-G group (omeprazole-ginseng). Renal functions and histological renal tissues were investigated. Results: The OM group had significantly high levels of urea, creatinine and 24-hours protein urea. A significant glomerular, tubular and interstitial injury was observed; congestion, inflammatory cell infiltration, tubular damage, increased collagen deposition and significant increases in COX-2 and caspase-3 immune expression. While adding ginseng with omeprazole resulted in marked improvement in these changes. Conclusion: Long-term use of omeprazole induced renal functional and morphological changes through induction of inflammatory reaction, fibrosis, cellular degeneration and apoptosis. By adding ginseng, these effects were ameliorated through its anti-fibrotic, anti-inflammatory, and anti-apoptotic effects.

show abstract

“…The There was a role of ginseng as a cytoprotective drug in rats' organs after exposure to many toxins such as Aflatoxin B1 (Zidan et al, 2015), thioacetamide (Mostafa et al, 2021)…”

Section: Anticancer Activitymentioning

confidence: 99%

A Review on The Potential Effective Cytoprotective Role of Ginseng in Rat's Organ

Allaf

2022

Journal of Applied Veterinary Sciences

View full text Add to dashboard Cite

Panax ginseng is among the herbal agents traditionally utilized for thousands of years. It is used commonly as dried roots with possible multifaceted medical characteristics, including anti-inflammatory, anti-neoplastic, tonic, antiviral, antifungal, and antioxidant, besides its potential actions in healing and restoration. Although many studies discussed the action of one of the components of Panax ginseng, several types of this herb include Panax quinquefolius in America, Pan Ginseng in Korea, and Panax notoginseng in China. This study aims to review the articles that focus on the potential roles of ginseng in general, highlighting the effect of ginseng on several rats' organs. A brief review of the articles discussed the role of ginseng as an anti-inflammatory, anti-neoplastic, tonic, antiviral, antifungal, and antioxidant agent. Several works concluded the multifaceted actions of ginseng at both clinical and animal levels. The products which are obtained from the natural origins (as ginseng)are gained major concerns as pharmacological agents as they are potentially helpful in treating several disorders by their several cytoprotective roles in oxidative stress, inflammation infection(viral and bacterial), malignancy, diabetes mellitus, problems of sexuality beside the disorders of central nervous and cardiovascular systems as these herbs have little toxicity. There is a need to develop new components of ginseng.

show abstract

Evaluating the Protective Role of Ginseng against Histological and Biochemical Changes Induced by Aflatoxin B1 in the Renal Convoluted Tubules of Adult Male Albino Rats

Cited by 5 publications

References 33 publications

Ginseng Ameliorates Effect of Prolonged Use of Omeprazole in Rat Renal Cortex through Decreasing Inflammation, Fibrosis and Apoptosis

Ginseng Ameliorates Effect of Prolonged Use of Omeprazole in Rat Renal Cortex through Decreasing Inflammation, Fibrosis and Apoptosis

Reno-protective Role of Ginseng in Counteracting the Long-term Omeprazole Induced Adverse Effects in Albino Rats via Modulation of Inflammation, Apoptosis and Fibrosis

A Review on The Potential Effective Cytoprotective Role of Ginseng in Rat's Organ

Contact Info

Product

Resources

About