Evaluating the Radioprotective Effect of Curcumin on Rat’s Heart Tissues

Kolivand, Sedighe; Amini, Peyman; Saffar, Hiva; Rezapoor, Saeed; Motevaseli, Elahe; Najafi, Masoud; Nouruzi, Farzad; Shabeeb, Dheyauldeen; Musa, Ahmed Eleojo

doi:10.2174/1874471011666180831101459

Cited by 33 publications

(17 citation statements)

References 23 publications

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“…This finding made us consider the possibility of metformin to prevent radiation‐induced heart damages. This was similar to curcumin, that suppresses the up regulation of transcription factors such as NF‐kB and immune mediators like COX‐2 after radiation exposure, thus curcumin can ameliorate genotoxicity and enhancement late effects of ionizing radiation as well as carcinogenesis …”

Section: Discussionmentioning

confidence: 65%

Metformin modulates cardiac endothelial dysfunction, oxidative stress and inflammation in irradiated rats: A new perspective of an antidiabetic drug

Karam

Radwan

2019

Clin Exp Pharma Physio

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Cardiovascular disease is one of the most pivotal disorders after radiotherapy. The aim of this study investigates the possible protective effect of metformin against gamma radiation‐induced heart damage in male rats. Group 1 (control) received saline, group 2 was whole body gamma‐irradiated 5 Gy, group 3 was orally administered metformin 50 mg/kg/day for 2 weeks, group 4 received metformin 50 mg/kg/day for 1 week, then exposed to whole‐body gamma radiation at a dose of 5 Gy and continued with metformin for further 1 week. The results revealed that the administration of metformin to irradiated rats significantly ameliorated the changes in cardiac biomarkers (LDH and CK‐MB) compared with irradiated group. Heart catalase and SOD activities showed normal level when compared with the irradiated group. Also, NF‐κB, IL‐6 and TNF‐ α levels were markedly decreased compared with the corresponding values of irradiated group. Consequently, metformin reduced E‐selectin as well ICAM and VCAM‐1. These results confirmed by histopathological examination. In conclusion, concomitant administration of metformin during radiotherapy acts as a potent heart protector from oxidative stress, inflammatory mediators and endothelial dysfunction induced damages. Results thus hold a great promise for a new implication of an antidiabetic drug (metformin) as adjunct to radiotherapy.

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Section: Discussionmentioning

confidence: 65%

Metformin modulates cardiac endothelial dysfunction, oxidative stress and inflammation in irradiated rats: A new perspective of an antidiabetic drug

Karam

Radwan

2019

Clin Exp Pharma Physio

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“…Before irradiation, rats were anesthetised via an intraperitoneal injection of ketamine 10% (80 mg/kg) and xylazine 2% (5 mg/kg). Afterwards, they were irradiated with a 10 Gy single dose to the abdominal and pelvis region using a cobalt-60 gamma ray source at a dose rate of 0.65 cGy per minute and a source to skin distance of 1 m. The choice of the curcumin dose was based on a previous study by Kolivand et al, 7 while that of radiation was according to Jourdan et al 8 All rats were sacrificed 1, 2, or 4 weeks after irradiation. Afterwards, their skin tissues were carefully removed and frozen at −80°C.…”

Section: Study Design and Irradiationmentioning

confidence: 99%

<p>Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin</p>

Shabeeb¹,

Musa²,

Ali³

et al. 2020

DDDT

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Objective: Side-effects to normal tissues reduce the therapeutic window of radiotherapy. During radiotherapy, the skin is inevitably exposed to doses of ionizing radiation, leading to varying degrees of skin damage. Natural antioxidants have been explored for their radioprotective potentials. Thus, the present study aimed to investigate the protective effect of curcumin against radiotherapy-induced oxidative damage to the skin. Methods: Forty rats were divided into four groups as follows: vehicle control (without irradiation or drug treatment), treatment with 150 mg/kg curcumin, 10 Gy single dose irradiation only, and 150 mg/kg curcumin plus 10 Gy radiation (RC). In the treatment groups, each rat was treated orally with 150 mg/kg curcumin 1 day before irradiation to 3 consecutive days after irradiation. Weeks 1, 2, or 4 after irradiation, all rats were sacrificed and their skin tissues collected and frozen at −80°C for the determination of malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity in skin tissues. Results: Radiotherapy-induced oxidative injury to the skin was evidenced by elevated MDA levels as well as depleted CAT, SOD, and GSH-Px activities. However, the administration of curcumin before and after irradiation prevented radiotherapy-induced oxidative damage by significantly elevating the activities of antioxidant enzymes. Conclusion: From the findings of the present study, curcumin showed potential for protection against radiotherapy-induced oxidative injury to the skin. However, future studies are required to evaluate its clinical efficacy.

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“…Their results 10 weeks after irradiation showed that curcumin attenuated the upregulation of IL-4 protein and its receptor, IL4Ra1, as well as prevented infiltration of lymphocytes and macrophages. It also attenuated the expression of dual oxidases (Duox1 and Duox2), enzymes responsible for the stabilization of extracellular matrix via oxidative cross-linking [74].…”

Section: Curcuminmentioning

confidence: 99%

Radiation-Induced Heart Diseases: Protective Effects of Natural Products

Musa

Shabeeb

2019

Medicina

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Cardiovascular diseases (CVDs) account for the majority of deaths worldwide. Radiation-induced heart diseases (RIHD) is one of the side effects following exposure to ionizing radiation (IR). Exposure could be from various forms such as diagnostic imaging, radiotherapy for cancer treatment, as well as nuclear disasters and nuclear accidents. RIHD is mostly observed after radiotherapy for thoracic malignancies, especially left breast cancer. RIHD may affect the supply of blood to heart muscles, leading to an increase in the risk of heart attacks to irradiated persons. Due to its dose-limiting consequence, RIHD has a negative effect on the therapeutic efficacy of radiotherapy. Several methods have been proposed for protection against RIHD. In this paper, we review the use of natural products, which have shown promising results for protection against RIHD.

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Evaluating the Radioprotective Effect of Curcumin on Rat’s Heart Tissues

Abstract: Curcumin could reduce radiation-induced heart injury markers in rats.

Cited by 33 publications

References 23 publications

Metformin modulates cardiac endothelial dysfunction, oxidative stress and inflammation in irradiated rats: A new perspective of an antidiabetic drug

Metformin modulates cardiac endothelial dysfunction, oxidative stress and inflammation in irradiated rats: A new perspective of an antidiabetic drug

<p>Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin</p>

Radiation-Induced Heart Diseases: Protective Effects of Natural Products

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