Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies

Mentzelou, Maria; Papadopoulou, Sousana K.; Papandreou, Dimitrios; Spanoudaki, Maria; Dakanalis, Antonios; Vasios, Georgios K.; Voulgaridou, Gavriela; Pavlidou, Eleni; Mantzorou, Maria; Giaginis, Constantinos

doi:10.3390/metabo13030370

Cited by 4 publications

(4 citation statements)

References 86 publications

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“…Sleep Deprivation and Quality: Non-traditional work schedules can lead to inadequate or poor-quality sleep, which is a known risk factor for cardiovascular issues [ 33 ]. Sleep deprivation and irregular sleep patterns can lead to increased systemic inflammation, insulin resistance, and the dysregulation of metabolic processes, all of which contribute to cardiovascular risk [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Tackling Shift Work: Cardiovascular Health in the Auto Industry

Bunescu,

Gheorman,

Marcu

et al. 2024

Healthcare

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Shift work, particularly in the auto industry, presents significant health challenges, notably in how it impacts cardiovascular health due to irregular work schedules and associated sleep disruptions. This prospective study evaluated 4683 workers from a single Romanian automotive enterprise to investigate the relationship between fixed shift work schedules and cardiovascular health outcomes. Our analysis focused on fixed-shift workers, excluding those on rotating shifts to reduce variability and enhance the clarity of the findings. The findings reveal that night shift workers are at a heightened risk of cardiovascular diseases (CVDs) compared to their day shift counterparts. Night shift workers demonstrated a higher CVD incidence (4.3%) compared to day shift workers (2.6%), with an odds ratio (OR) of 1.68 (95% CI: 1.08 to 2.62, p = 0.021). This association remained significant after adjusting for potential confounders, with an adjusted OR of 1.74 (95% CI: 1.09 to 2.75, p = 0.019). Male night shift workers exhibited a significantly higher CVD incidence (4.5%) compared to male day shift workers (3.0%), with an OR of 1.75 (95% CI: 1.07 to 2.89, p = 0.026). Female night shift workers also showed a higher CVD incidence (3.4%) compared to female day shift workers (1.3%), although this was not statistically significant. These findings underscore the urgent need for targeted interventions and effective strategies to mitigate these risks and promote the cardiovascular health and overall well-being of shift workers in the auto industry. This research contributes to a deeper understanding of how non-traditional work schedules affect health and provides a basis for implementing protective measures in occupational settings.

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Section: Discussionmentioning

confidence: 99%

Tackling Shift Work: Cardiovascular Health in the Auto Industry

Bunescu,

Gheorman,

Marcu

et al. 2024

Healthcare

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“… 1 , 22 Also, altered circadian rhythms such as seen in night shift workers have been associated with a higher risk of breast cancer, cardiovascular disease, and metabolic derangements. 23 Despite multiple studies linking altered circadian physiology with various diseases, 24 , 25 there is limited evidence for a clear association between disrupted circadian rhythms and mortality. Data from this study establishes a clear link between circadian dysfunction and increased mortality.…”

Section: Discussionmentioning

confidence: 99%

Dozing Off With Drosophila: The Effect of Disrupted Circadian Rhythms and Sleep Disturbance on Mortality, Mood, and Addiction

Lateef,

Pokharel,

Shafin

2023

J Exp Neurosci

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Many environmental factors can disrupt sleep and circadian rhythms, yet the consequences of such disruptions are poorly understood. The main goals of this project were to study the effects of disrupted circadian rhythms and sleep disturbance on Drosophila melanogaster’s: (1) lifespan, (2) depression-like behaviors, and (3) propensity to consume caffeine-containing media. Three experimental groups were used: controls, Circadian Dysfunction (CD), and Sleep Disturbance (SD). Circadian disruption (CD): used flies with Tim01 mutation, which eliminates circadian behavioral rhythms. Sleep disturbance (SD): used flies subjected to hourly light exposure and manual mechanical disruption, for 48 hours. To assess the effect on lifespan, the percent of flies surviving over time, within each group, was calculated. Impaired geotaxis, or loss of climbing motivation, was assessed as a measure of a depression-like state. Preference for caffeine-containing food was evaluated using a choice chamber where caffeine enriched, and regular media were presented to flies. Group differences were analyzed with survival curves. Chi-square tests were used for the categorical variables. Survival curve analysis showed that Flies with the timeless gene mutation ( tim01) have a significantly shorter lifespan than controls. Geotaxis was not significantly impaired by sleep disturbance, but it was negatively affected by circadian dysfunction. Both the Circadian Dysfunction and Sleep Disturbance groups showed a preference for caffeine-containing food, after 72 hours of exposure to it, although the Circadian Dysfunction group was much more affected than the Sleep Disturbance group. Sleep and circadian disturbances can negatively influence physical and mental wellbeing and the accompanying molecular mechanisms, as well as disrupted brain physiology, must be studied. It is critical to identify and minimize social and environmental disruptors of such biological rhythms.

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“…Pored toga, ostaje da se utvrdi da li ponovljena izloženost cirkadijalnoj neusklađenosti (na primer, tokom rada u noćnoj smeni) i usklađivanju (slobodni dani) hronično menja hormone apetita i unos energije, odnosno treba istražiti san kod ovih radnika jer postoje studije koje pokazuju štetne efekta lošeg kvaliteta sna i kratkog trajanja sna jer ova uloga još uvek nije kvantifikovana. Potrebne su dalje studije koje bi ispitale individualne razlike između polova i potvrdile vezu između obrazaca spavanja i buđenja i faktora načina života, kao što su navike u ishrani, fizička aktivnost i navika pušenja [46,47].…”

Section: Ishrana Radnika Koji Rade U Smenamaunclassified

“…Apart from this, it remains to be determined whether repeated exposure to circadian misalignment (for example, when working the night shift) and alignment (days off ) chronically alters appetite hormones and energy intake, i.e., sleep should be examined in these ishrana radnika koji rade u noćnoj smenirazlog ili izgovor za nepravilnu ishranu dietary habits of night shift workersa reason or an excuse for poor nutrition workers as there are studies showing harmful effects of poor sleep quality and short sleep duration considering this role has not been quantified yet. Further studies are needed to examine individual differences between the sexes and confirm the relationship between sleepwake patterns and lifestyle factors, such as dietary habits, physical activity and smoking habit [46,47].…”

Section: Efekat Rada U Smenama Na Zdravlje Zaposlenihmentioning

confidence: 99%

Dietary habits of night shift workers: A reason or an excuse for poor nutrition

Anđelković,

Babić

2024

Srpski medicinski časopis Lekarske komore

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The availability of artificial light and light-emitting devices has changed human life in relation to time, enabling 24-hour health care, trade, and production, as well as the expansion of social life around the clock. In Europe, about 21% of the labor force consists of shift workers. 10% of the employed population work evening shifts or the night shift, and 7% of employees in Europe regularly work the night shift. According to the Bureau of Labor Statistics, more than 15 million Americans work the night shift. Shift work, especially night-time work, seriously affects dietary habits. It is known that night-time work produces a conflict between the socially determined rhythm of eating and the circadian biological rhythms related to the feeling of hunger, satiety, as well as the metabolism itself. Night meals cause disorders of intestinal motility, affect digestion, absorption, but also the utilization of nutrients and possible medical therapy (if the individual has one). From the point of view of chronobiology, humans belong to diurnal species, which to a certain extent explains why night shift workers have a decreased appetite at night, when the human body is programmed for rest and fasting, as well as for endogenous mobilization of glucose. From the psychosocial aspect, shift workers usually experience a discrepancy between their daily routines (including the meal schedule) and those they have with family and friends, which further leads to even more severe disorders of dietary habits. However, it is difficult to give dietary recommendations regarding nutrition. Firstly, there are no clear views on whether night shift workers should eat during the night hours or not. Secondly, even if night eating is encouraged, definitive evidence is lacking on which types of food should be consumed and which should be avoided. Thirdly, the most nutritious foods may not be available at that time of night. Finally, eating at night certainly has an impact on the metabolism. With all the above in mind, we have tried to provide some useful guidelines regarding these issues.

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Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies

Cited by 4 publications

References 86 publications

Tackling Shift Work: Cardiovascular Health in the Auto Industry

Tackling Shift Work: Cardiovascular Health in the Auto Industry

Dozing Off With Drosophila: The Effect of Disrupted Circadian Rhythms and Sleep Disturbance on Mortality, Mood, and Addiction

Dietary habits of night shift workers: A reason or an excuse for poor nutrition

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