Evaluating the Role of lncRNAs in the Incidence of Cardiovascular Diseases in Androgenetic Alopecia Patients

Roohaninasab, Masoumeh; yavari, Shadnaz fakhteh; Babazadeh, Motahareh; Hagh, Rozita Adldoosti; Pazoki, Mahboubeh; Amrovani, Mehran

doi:10.1007/s12012-022-09742-w

Cited by 2 publications

(3 citation statements)

References 145 publications

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“…Etiology believes that androgen-stimulated hair follicle miniaturization targets the genetically predisposed hair follicles, which causes the gradual replacement of large, terminal hairs with barely perceptible, vellus hairs in affected areas (Asfour et al, 2023;Glickman et al, 2021;Vinay et al, 2023;Hamed et al, 2022;Sözen et al, 2022). The etiology of the AGA causes an imbalanced control of hair growth due to the intra-and peri-follicular expression of particular regulatory molecules and their receptors (Hamed et al, 2022;Sözen et al, 2022;Qiu et al, 2022). Another pathological factor is the catagen, which occurs as a consequence of decreased levels of anagen due to the basic fibroblast growth factor (GF), insulin-like GF-1, and vascular endothelial GF simultaneously because of high expression of cytokines such as tumor necrosis factor-alpha (TNF-α), transforming growth factor beta-1 (TGFβ-1), interleukin-1alpha (IL-1α), chemokines, etc (Arefi et al, 2020;Sözen et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Insulin resistance (IR) is the underlying pathophysiology of MetS, characterized by a cluster of conventional and nonconventional cardiovascular risk factors that increase lipid profiles and their receptors. Which is considered to be a positive marker for the early onset of AGA development (Krysiak et al, 2022;Roohaninasab et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…The association between AG and metabolic syndrome was defined in a significant number of previous epidemiological studies (Dawoud et al, 2023;Qiu et al, 2022). Although some studies have found no relationship, the majority have supported the notion that suffering from AGA is correlated with cardiovascular health risk, with conflicting results (Arefi et al, 2020) and few pieces of literature also specified that cardiovascular risk (CVR) is associated with AGA as compared with normal individuals (Arefi et al, 2020;Saafan et al, 2021;Dawoud et al, 2023;Zhu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of cardiovascular risk factors in male androgenetic alopecia: A case control study in a tertiary care hospital of western Odisha

Madhual,

Nayak,

Dalei

et al. 2023

IJERR

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Androgenic alopecia (AGA) is the most common cause of patterned hair loss among males which is characterized by progressive hair loss from the bi-temporal and vertex regions of the scalp. Although previous epidemiological studies found an association between metabolic syndrome (MetS), and cardiovascular disease (CVD) risk among adult AGA male patients, there has been no comprehensive research till now to establish this correlation between AGA and cardiovascular risk and there is a paucity of data regarding this association. Two hundred men were included in the study, N = 100 AGA patients included in the patient group, and the rest in the control group. In both groups, the parameters for MetS such as family history, socioeconomic status, obesity, blood pressure, and lipid profile), and in the presence of the CAA plaques and carotid intima-media thickness (CIMT) using Doppler ultrasonography were established. The degree of AGA was asses by using the Hamilton-Norwood grade (I-VII) system for males. Statistical analysis was performed using the Chi-square test. AGA was found in 11.6% of OPD patients, whereas 3 patients have CAA plaque and 6 cases have C-IMT from the patient's group. There was a statistical association between male AGA with MetS, and insulin-resistant patients (P = 0.001 and 0.0004, respectively). A positive family history of AGA patients, hypertension, DM, and CVD was found to be significantly more frequent in study cases than in the controls (P <0.05). Patients with AGA appear to have a highly prevalent risk of developing CVD and CAA plaque. Therefore, clinical evaluation of each AGA patient’s cases is needed, especially for grade III and above which may help prevent CVD in the future. Timely intervention and lifestyle changes in male AGA patients can fulfil the ultimate objective of reducing cardiovascular complications in the future.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of cardiovascular risk factors in male androgenetic alopecia: A case control study in a tertiary care hospital of western Odisha

Madhual,

Nayak,

Dalei

et al. 2023

IJERR

View full text Add to dashboard Cite

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Androgenetic Alopecia in Men: An Update On Genetics

Sadasivam,

Sambandam,

Kaliyaperumal

et al. 2024

Indian Journal of Dermatology

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Androgenetic alopecia (AGA) is defined as the alopecia induced by androgens in genetically predisposed individuals. AGA results in progressive miniaturization of the hair follicles leading to vellus transformation of terminal hair. The high prevalence and wide range of expressed phenotypes in AGA is a result of a polygenic inheritance mode. The androgen receptor (AR) gene located on the X chromosome at Xq11-12 is the first gene to show genetic association with AGA. Newer genetic associations with AGA are under study. In early-onset AGA, obesity, diabetes, hypertension, dyslipidaemia, insulin resistance, benign prostatic hyperplasia (BPH), prostate cancers and coronary artery disease (CAD) are associated with AGA. Screening of early-onset AGA patients and intervention for metabolic syndrome and insulin resistance can prevent the development of cardiovascular disease (CVD) at an early stage. As effective treatments continue to be topical minoxidil, systemic finasteride and hair transplantations, newer modalities are under investigation. Understanding the genetic factors involved in AGA and continued research into newer therapies, such as cell-based therapies, will lead to effective treatment and improve the quality of life in patients with AGA.

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Evaluating the Role of lncRNAs in the Incidence of Cardiovascular Diseases in Androgenetic Alopecia Patients

Cited by 2 publications

References 145 publications

Assessment of cardiovascular risk factors in male androgenetic alopecia: A case control study in a tertiary care hospital of western Odisha

Assessment of cardiovascular risk factors in male androgenetic alopecia: A case control study in a tertiary care hospital of western Odisha

Androgenetic Alopecia in Men: An Update On Genetics

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