Evaluating the spectrum-effect profiling and pharmacokinetics of Tieshuang Anshen Prescription with better sedative-hypnotic effect based on Fe2+ than Hg2+

Zhai, Manhuayun; Gong, Dandan; Gao, Qiannan; Zhang, Hong; Sun, Guoxiang

doi:10.1016/j.biopha.2021.111923

Cited by 5 publications

(1 citation statement)

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“…Similar studies have also been conducted on the optimization of nine different ratios of Salviae Miltiorrhizae Radix et Rhizoma-Chuanxiong Rhizoma herbal pairs (1:0, 1:1, 2:1, 3:1, 5:1, 1:5, 1:3, 1:2 and 0:1) [99], and the optimization of extracts of Curcumae Rhizoma-Sparganii Rhizoma with different polar elution fractions (water, 20%, 40%, 60%, 80%, and 95% ethanol) [100]. In the optimization of component compatibility, one study used Fe 2+ instead of Hg 2+ to improve Zhusha Anshen Pill to create Tieshuang Anshen Prescription, which not only improved the sedative and hypnotic effect of the compound but also avoided the toxicity of Hg 2+ in the previous prescription [101].…”

Section: Pharmaceutical Process Optimization Of Tcmmentioning

confidence: 99%

Spectrum–Effect Relationships as an Effective Approach for Quality Control of Natural Products: A Review

He,

Zhang,

Yang

et al. 2023

Molecules

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As natural products with biological activity, the quality of traditional Chinese medicines (TCM) is the key to their clinical application. Fingerprints based on the types and contents of chemical components in TCM are an internationally recognized quality evaluation method but ignore the correlation between chemical components and efficacy. Through chemometric methods, the fingerprints represented by the chemical components of TCM were correlated with its pharmacodynamic activity results to obtain the spectrum–effect relationships of TCM, which can reveal the pharmacodynamic components information related to the pharmacodynamic activity and solve the limitations of segmentation of chemical components and pharmacodynamic research in TCM. In the 20th anniversary of the proposed spectrum–effect relationships, this paper reviews its research progress in the field of TCM, including the establishment of fingerprints, pharmacodynamic evaluation methods, chemometric methods and their practical applications in the field of TCM. Furthermore, the new strategy of spectrum–effect relationships research in recent years was also discussed, and the application prospects of this technology were discussed.

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Section: Pharmaceutical Process Optimization Of Tcmmentioning

confidence: 99%