Evaluating the Theory of Bone Mechanoregulation in the Physiological Loading Scenario

Lyu, Yongtao; Zhao, Wenying; Li, Junyan; Wu, Chengwei

doi:10.1142/s0219519418500112

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Additionally, it was found that after the PTH treatment, the increasing TPA started from the midshaft region, while there is no clear pattern for the increasing TEA. One possible explanation for the adaptation pattern of TPA is that the midshaft region of the mouse tibia bears more weight than other regions of the mouse tibia during every day activities [ 32 ], which stimulates more bone formation activities, in agreement with the bone mechano-regulation mechanism [ 33 ]. Regarding the effect of PTH on the TEA, it is still unclear which parameter is the main one that regulates the increase of TEA.…”

Section: Discussionmentioning

confidence: 99%

Effect of parathyroid hormone on the structural, densitometric and failure behaviors of mouse tibia in the spatiotemporal space

Lyu

Zhu

et al. 2019

PLoS ONE

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Parathyroid hormone (PTH) is an anabolic bone drug approved by the US Food and Drug Administration (FDA) to treat osteoporosis. However, previous studies using cross-sectional designs have reported variable and sometimes contradictory results. The aim of the present study was to quantify the localized effect of PTH on the structural and densitometric behaviors of mouse tibia and their links with the global mechanical behavior of bone using a novel spatiotemporal image analysis approach and a finite element analysis technique. Twelve female C57BL/6J mice were divided into two groups: the control and PTH treated groups. The entire right tibiae were imaged using an in vivo micro-computed tomography (μCT) system eight consecutive times. Next, the in vivo longitudinal tibial μCT images were rigidly registered and divided into 10 compartments across the entire tibial space. The bone volume (BV), bone mineral content (BMC), bone tissue mineral density (TMD), and tibial endosteal and periosteal areas (TEA and TPA) were quantified in each compartment. Additionally, finite element models of all the tibiae were generated to analyze the failure behavior of the tibia. It was found that both the BMC and BV started to increase in the proximal tibial region, and then the increases extended to the entire tibial region after two weeks of treatment ( p < 0.05). PTH intervention significantly reduced the TEA in most tibial compartments after two weeks of treatment, and the TPA increased in most tibial regions after four weeks of treatment ( p < 0.05). Tibial failure loads significantly increased after three weeks of PTH treatment ( p < 0.01). The present study provided the first evidence of the localized effect of PTH on bone structural and densitometric properties, as well as their links with the global mechanical behaviors of bone, which are important pieces of information for unveiling the mechanism of PTH intervention.

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Section: Discussionmentioning

confidence: 99%

Effect of parathyroid hormone on the structural, densitometric and failure behaviors of mouse tibia in the spatiotemporal space

Lyu

Zhu

et al. 2019

PLoS ONE

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“…Bone length was measured from the pixel of the most tibial bone to the most distal bone. To account for the longitudinal growth (small in the considered age range, approximately 300 − 400 μ m [42]). We have considered 80% of the tibia length below the proximal growth plate.…”

Section: Discussionmentioning

confidence: 99%

A new method to monitor bone geometry changes at different spatial scales in the longitudinal in vivo μCT studies of mice bones

et al. 2019

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Longitudinal studies of bone adaptation in mice using in vivo micro-computed tomography ( μ CT) have been commonly used for pre-clinical evaluation of physical and pharmacological interventions. The main advantage of this approach is to use each mouse as its own control, reducing considerably the sample size required by statistical power analysis. To date, multi-scale estimation of bone adaptations become essential since the bone activity that takes place at different scales may be associated with different bone mechanisms. Measures of bone adaptations at different time scales have been attempted in a previous study. This paper extends quantification of bone activity at different spatial scales with a proposition of a novel framework. The method involves applying level-set method (LSM) to track the geometric changes from the longitudinal in vivo μ CT scans of mice tibia. Bone low- and high-spatial frequency patterns are then estimated using multi-resolution analysis. The accuracy of the framework is quantified by applying it to two times separated scanned images with synthetically manipulated global and/or local activity. The Root Mean Square Deviation (RMSD) was approximately 1.5 voxels or 0.7 voxels for the global low-spatial frequency or local high-spatial frequency changes, respectively. The framework is further applied to the study of bone changes in longitudinal datasets of wild-type mice tibiae over time and space. The results demonstrate the ability for the spatio-temporal quantification and visualisation of bone activity at different spatial scales in longitudinal studies thus providing further insight into bone adaptation mechanisms.

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Computational modelling of bone microstructure

Lü

2021

Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System

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Evaluating the Theory of Bone Mechanoregulation in the Physiological Loading Scenario

Cited by 4 publications

References 37 publications

Effect of parathyroid hormone on the structural, densitometric and failure behaviors of mouse tibia in the spatiotemporal space

Effect of parathyroid hormone on the structural, densitometric and failure behaviors of mouse tibia in the spatiotemporal space

A new method to monitor bone geometry changes at different spatial scales in the longitudinal in vivo μCT studies of mice bones

Computational modelling of bone microstructure

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