Evaluating the therapeutic approach in pregnancies complicated by borderline glucose intolerance: a randomized clinical trial

Bonomo, Matteo; Corica, Domenico; Mion, Elena; Goncalves, Danielle Freire; Motta, G; Merati, R; Ragusa, Antonio; Morabito, Alberto

doi:10.1111/j.1464-5491.2005.01690.x

Cited by 89 publications

(79 citation statements)

References 25 publications

(37 reference statements)

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“…As the 75 g OGCT can be regarded as a surrogate marker of meal postprandial glycaemia [10] , the findings of this study agree with previous findings in that mild elevations in glucose tolerance, or mild dietary glucose elevations within the normal range, may result in increased fetal growth [11] .Patel VN et al conducted a study on 93 pregnant women to monitor longitudinal changes in blood glucose levels in pregnancy and to co-relate it with various maternal and fetal outcomes. They observed that maternal postprandial blood glucose levels affect the birth weight of the baby and also mode of delivery [12] .…”

Section: Discussion and Conclusion:-supporting

confidence: 88%

Correlation of Higher Maternal Blood Sugar Levels With Neonatal Birth Weight in Non-Diabetic Pregnant Mothers.

Mukhi¹,

Nimbargi²,

Mehendale³

2016

IJAR

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Section: Discussion and Conclusion:-supporting

confidence: 88%

Correlation of Higher Maternal Blood Sugar Levels With Neonatal Birth Weight in Non-Diabetic Pregnant Mothers.

Mukhi¹,

Nimbargi²,

Mehendale³

2016

IJAR

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“…The discrepancy between WHO-GDM prevalence and modified IADPSG-GDM prevalence was highest early in pregnancy. Given the well-documented adverse effects of GDM, early detection may improve maternal and fetal outcomes (37,38,39). The high discrepancy between WHO-GDM prevalence and modified IADPSG-GDM prevalence in early pregnancy in women with PCOS is noteworthy and should be explored further before changing routines.…”

Section: Discussionmentioning

confidence: 99%

Gestational diabetes mellitus among Norwegian women with polycystic ovary syndrome: prevalence and risk factors according to the WHO and the modified IADPSG criteria

Helseth

Salvesen

Carlsen

2013

European Journal of Endocrinology

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Objective: The consequences of the recently proposed International Association of Diabetes in Pregnancy Study Group (IADPSG) criteria for gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS) are not known. We compared the prevalence rates and risk factors for GDM in PCOS women according to both the WHO and the modified IADPSG criteria. Design: Post hoc analyses from a randomized, multicenter study were used. Methods: Fasting and 2-h plasma glucose levels were measured using a 75 g oral glucose tolerance test. GDM was diagnosed according to both the WHO and the modified IADPSG criteria.Results: The prevalence rates of GDM according to the WHO and the modified IADPSG criteria were 9.2 and 15.0% at week 12, 18.7 and 18.7% at week 19, and 25.6 and 24.2% at week 32. Shorter stature and increased insulin levels were correlated with WHO-GDM, but not with modified IADPSG-GDM at weeks 12 and 19. Less weight gain in pregnancy predicted GDM according to both sets of criteria. GDM diagnosis was correlated with less maternal weight loss the first year post-partum. Conclusions: No difference was found in the prevalence of GDM between the two sets of criteria used. Less weight gain in pregnancy was associated with GDM, independent of the diagnostic criteria used. Reduced weight loss the first year post-partum in women with GDM raises the question of whether GDM diagnosis per se or the fact that these women lose less weight after pregnancy predicts later diabetes mellitus.

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“…These subjects were born in 1978/1979 and, at the time, the presence of gestational diabetes was not universally assessed. To overcome the lack of this information in our cohort, we assumed that a subset of LGA subjects born asymmetric (PIO3.1) were likely to be an offspring of diabetic mothers (24).…”

Section: Phenotype Measurementsmentioning

confidence: 99%

Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age

Bueno

Espineira²,

Fernandes-Rosa³

et al. 2010

European Journal of Endocrinology

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Objective: To assess whether the K11391GOA polymorphism in the regulatory region of the adiponectin gene (ADIPOQ) is associated with birth size, postnatal growth, adiponectinemia, and cardiometabolic risk in adult life. Design: Case-control study nested within a prospective cohort of 2063 community subjects born in 1978/1979 and followed since birth to date. Methods: ADIPOQ K11391GOA genotype-phenotype associations were evaluated in 116 subjects born large for gestational age (LGA) and 392 gender-matched controls at birth (birth size), at 8-10 years (catch-down growth), and at 23-25 years of age (cardiometabolic profile). Results: The K11391A variant allele frequency was higher in LGA subjects (PZ0.04). AA genotype was associated with augmented probability of being born LGA (odds ratioZ4.14; 95% confidence interval: 1.16-16.7; PZ0.03). This polymorphism was associated neither with body composition nor with postnatal growth pattern. At the age of 23-25 years, the K11391A variant allele was associated with higher serum adiponectin levels (GG: 10.7G6.2 versus GA: 12.2G6.5 versus AA: 14.2 G6.8 mg/ml; P!0.01). Subjects born LGA presented higher body mass index (BMI; PZ0.01), abdominal circumference (PZ0.04), blood pressure (PZ0.04), and homeostasis assessment model for insulin resistance (PZ0.01) than adequate for gestational age. Symmetry at birth did not influence these variables. The occurrence of catch-down of weight was associated with lower BMI and abdominal circumference (P!0.001) at 23-25 years. Conclusions: The K11391A ADIPOQ gene variant was associated with increased chance of being born LGA and with higher adiponectin levels in early adult life.

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Evaluating the therapeutic approach in pregnancies complicated by borderline glucose intolerance: a randomized clinical trial

Abstract: Even very mild alterations in glucose tolerance can result in excessive or disharmonious fetal growth, which may be prevented by simple, non-invasive therapeutic measures.

Cited by 89 publications

References 25 publications

Correlation of Higher Maternal Blood Sugar Levels With Neonatal Birth Weight in Non-Diabetic Pregnant Mothers.

Correlation of Higher Maternal Blood Sugar Levels With Neonatal Birth Weight in Non-Diabetic Pregnant Mothers.

Gestational diabetes mellitus among Norwegian women with polycystic ovary syndrome: prevalence and risk factors according to the WHO and the modified IADPSG criteria

Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age

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