The radical alterations in the factors determining energy intake and expenditure that we have witnessed over recent times have fundamentally changed the way we view the interplay between the environment and our physical selves. It was only at the advent of the 20th century that technological advancement finally began to squeeze out the manual labour associated with the production and transport of goods. Later in the century, this trend started to infiltrate the home where new technologies, such as electric and gas cookers, central heating, washing machines, vacuum cleaners, and dish washers all made significant inroads into the amount of physical labour associated with everyday life.Our modern environments are now completely divorced from those in which we evolved; indeed, all the necessities of modern life, such as shopping, banking, working, socialisation, and entertainment can be fulfilled while sitting in front of a screen. As a result, we are surrounded by a landscape of energy dense foods designed to appeal to our innate desire to maximise energy intake and storage, while the need for vigorous activity has evaporated. The trade-off has been an epidemic of obesity and metabolic dysfunction.