Evaluating the Transvaginal Ultrasound Diagnostic Criteria for Abnormal First-Trimester Pregnancy With Follow-Up Into the Third Trimester and Validation of Results

Addas, J.; Alabousi, Abdullah; Almohaimede, Khaled; Abdullah, Peri; Atri, Mostafa

doi:10.1016/j.jogc.2020.11.020

Cited by 1 publication

(2 citation statements)

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“…The safety and efficacy of early and moderate use of progesterone have been generally confirmed 17 . Transvaginal ultrasound, which could detect the gestational sac at 5 weeks after fertilization or when the serum β‐hCG value reached approximately at 2000 mIU/mL, was considered as the most direct and useful test to confirm clinical pregnancy 21–23 …”

Section: Discussionmentioning

confidence: 96%

“…17 Transvaginal ultrasound, which could detect the gestational sac at 5 weeks after fertilization or when the serum β-hCG value reached approximately at 2000 mIU/mL, was considered as the most direct and useful test to confirm clinical pregnancy. [21][22][23] Theoretically, during the embryonic development, the trophoblast cells continuously proliferated and resulted in an enlarged gestational sac. The embryonic trophoblast cells are the site for the synthesis of β-hCG and E 2 .…”

Section: Discussionmentioning

confidence: 99%

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A mathematical model to predict the probability of a successful pregnancy

2022

J of Obstet and Gynaecol

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Aim: To develop a scoring system for the prediction of a successful pregnancy. Methods: Data were collected prospectively from women diagnosed with pregnancy from January 1, 2015, to December 31, 2018. Pregnant days, hormone levels, and gestational sac diameters were recorded. Relationships among the pregnancy days, hormones, and gestational sac were analyzed by Spearman correlation analysis. A scoring system was established and stratified by the 5th, 50th, and 95th percentile of hormone levels and gestational sac diameters on different pregnancy days. Pregnancy outcomes were predicted by the scores using quadratic polynomial regression analyses. A portable desktop analyzer was developed and the performance was evaluated by receiver operating characteristic (ROC) curve. Results: In 273 successful pregnancy cases, the length of gestational days was significantly correlated to beta-human chorionic gonadotropin (β-hCG) (r = 0.74, p < 0.001) and E 2 (r = 0.79, p < 0.001) levels, and the size of the gestational sac (r = 0.88, p < 0.001). Meanwhile, the size of gestational sac was positively correlated with β-hCG (r = 0.93, p < 0.001) and E 2 (r = 0.55, p < 0.001). For 273 delivery and 103 miscarriage cases included in this study, our scoring-based prediction model rendered an area under the ROC curve (AUC) of 0.86 with the sensitivity of 78.31% and the specificity of 80.83%. Conclusions: We successfully developed a scoring-based analyzer to evaluate the viability of embryos at different gestation stages and to predict the probability of a successful delivery, which would provide a reference for clinicians in postpregnancy management.

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Section: Discussionmentioning

confidence: 96%