Evaluating the Trends of Bloodstream Infections by Nonfermenting Gram Negative Bacilli among the Patients in a Tertiary Care Hospital of Western Part of India and its Antibiogram

Chaudhury, Nabamita; Paul, Retina; Misra, Rabindra Nath; Chaudhuri, Sankha Subhra; Mirza, Shazad; Sen, Sukanta

doi:10.20546/ijcmas.2019.801.121

Cited by 9 publications

(6 citation statements)

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“…were isolated in 15.9% cases each and only one isolate (2.2%) of Stenotrophomonas maltophila was isolated. These results differ from various Indian studies where Acinetobacter boumannii was the most common organism, followed by Strenotrophomonas maltophilia, and Pseudomonas aeruginosa 21,22 .…”

Section: Resultscontrasting

confidence: 99%

Gram negative organisms isolated from Blood Cultures and their Susceptibility Pattern

Munir¹,

Inam²,

Aslam³

et al. 2021

PJMHS

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Background: Bloodstream infections (BSIs) are an important frequent health problem in terms of their high incidence and lethal outcomes. The bacteria that frequently cause bacteremia are Staphylococcus, Streptococcus, Enterococcus, Escherichia coli, Klebsiella, Enterobacter, Pseudomonas, Neisseria and Haemophilus. Gram negative rods constitute a significant bulk in BSIs. The bloodstream infections due to multidrug resistant pathogens are on the rise globally making treatment more challenging. Aim: To identify the gram negative organisms causing blood stream infections and assess their susceptibility pattern so as to provide guidance for the empirical treatment hoping for better clinical outcome. Methodology: A retrospective, cross-sectional descriptive study carried out in Pathology Laboratory of Sharif City Hospital, Lahore. All the blood culture samples received in Microbiology laboratory between June 2017 to June 2019 were included in the study by non-probability consecutive sampling. Blood cultures were proceeded by subculturing on 1st and 5th day on MacConkey and Blood agar. The colonies obtained were identified through gram staining and biochemical profile. API20E was used for Enterobacteriaceae. Antibiotic susceptibility testing of the pathogens was by Kirby Bauer disc diffusion method. Results: In the current study 663 blood cultures were analyzed. Only 11.9% exhibited positive microbial growth. 55.7% of the positive cultures revealed gram negative bacteria. Among the pathogens isolated, E.coli was found to be responsible for BSIs in 22.7% cases, followed by Salmonella Typhi 20.4% and Klebsiella pneumoniae 18.1%.The gram negative rods exhibited a very high resistance for penicillins, cephalosporins and fluoroquinolones. The efficacy of aminoglycosides and results for carbapenems susceptibility were hopeful. Conclusion: The study shows that the Gram negative bacteria causing BSIs have shown unsatisfactory susceptibility to most of the commonly prescribed antimicrobials. The rising drug resistance has a major impact on the selection and prescription of antibiotics and calls for judicious use of antibiotics. Keywords: Gram Negative Organisms, Blood Culture, Antimicrobial Susceptibility Pattern

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Section: Resultscontrasting

confidence: 99%

Gram negative organisms isolated from Blood Cultures and their Susceptibility Pattern

Munir¹,

Inam²,

Aslam³

et al. 2021

PJMHS

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“…These result correlates with the findings of Kaur A et al (2018) 14 . Among the Acinetobacter isolates, we got sensitivity rate of Meropenem, Amikacin and Ceftazdime as 61.11%, 44.4% and 50.0% respectively and this result are quite similar to the study of Kaur A et al (2018) 14 and Jitendra Nath et al (2016) 22 .In our study we got 44.4% and 55.5% sensitivity rate of Amikacin and Imipenem respectively and Nabamita Chaudhary et al (2019) reported almost similar sensitivity rate of Amikacin and Imipenem (47.78% and 60.0% respectively) 23 .…”

Section: Resultssupporting

confidence: 90%

A Study of Prevalence and Antimicrobial Susceptibility Pattern of Non Fermenter Gram Negative Bacilli Isolated From Various Clinical Samples at a Tertiary Care Center, Jaipur

Suhaib¹

2019

jmscr

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Background: The present study was done to examine the prevalence and antimicrobial susceptibility pattern of NFGNB. Introduction: Non Fermenter Gram Negative Bacilli were previously considered as Non-pathogenic or contaminants but in past few years they have become a serious threat to the society as the frequency of their isolation and resistance towards antimicrobial agents is increasing rapidly. They have developed resistance towards commonly used antimicrobial agents as well as towards higher class also. Material & Methods: This study was done on all clinical samples received for culture and sensitivity over a period of 6 months in department of Microbiology, NIMS Medical College, Jaipur. Samples were received and processed according to standard procedures and Antimicrobial susceptibility testing was done by using Kirby Bauer's disc diffusion method. Result: From 674 bacterial isolates, 122 isolates (18.10%) were identified as NFGNB. Male population was highly affected by NFGNB as compared to female population. Pseudomonas species was commonly isolated followed by Acinetobacter species and Proteus species. Meropenem was most sensitive drug followed by Imipenem. Cephalosporins showed high resistance. Conclusion: Higher isolation rate of NFGNB seen in our study with high resistance towards first line antibiotics. Resistance towards Cephalosporins and Carbapenems indicates Beta-lactamases production by these organisms. So this study will be helpful in initiating proper empirical therapy of such patients, thus reducing the morbidity rate.

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“…The two most frequently encountered organisms, Pseudomonas aeruginosa and Acinetobacter baumanii complex, were also found in other studies. 11,12 Their antibiotic sensitivity was likewise similar, [13][14][15] thus suggesting a universality in our findings. Thus, to avoid increasing multidrug resistance, antibiotics need to be used only when their use is justified.…”

Section: Discussionsupporting

confidence: 69%

Prevalence and antibiogram of non-fermenting Gram-negative bacilli in blood stream infections: Study in a tertiary care centre, Western Uttar Pradesh, India

et al. 2021

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Non-fermenting Gram-negative bacilli (NFGNB) are emerging as important cause of blood stream infections. We aimed to determine the prevalence and antibiotic susceptibility pattern of NFGNB isolated from blood of patients with sepsis. We found, in 176 patients, the most common to be Pseudomonas aeruginosa (74) and Acinetobacter baumanii complex (39) followed by Stenotrophomonas maltophilia (16), Sphingomonas paucimobilis (6), Burkholderia cepacia (5) and Ochrobactrum anthropic (1). Generally, organisms showed a good sensitivity towards colistin, carbapenems and fluoroquinolones, whereas cephalosporins were ineffective.

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Evaluating the Trends of Bloodstream Infections by Nonfermenting Gram Negative Bacilli among the Patients in a Tertiary Care Hospital of Western Part of India and its Antibiogram

Cited by 9 publications

References 0 publications

Gram negative organisms isolated from Blood Cultures and their Susceptibility Pattern

Gram negative organisms isolated from Blood Cultures and their Susceptibility Pattern

A Study of Prevalence and Antimicrobial Susceptibility Pattern of Non Fermenter Gram Negative Bacilli Isolated From Various Clinical Samples at a Tertiary Care Center, Jaipur

Prevalence and antibiogram of non-fermenting Gram-negative bacilli in blood stream infections: Study in a tertiary care centre, Western Uttar Pradesh, India

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