The healthcare sector has made several changes after technological devices have been introduced to different processes. In addition, in Africa, the concept of “lean” comes to save medicines supply chains from waste. In this context, this chapter evolves the intersection of lean management in the public hospital medicines supply chain and digital solutions. Therefore, it focuses on how this integration can address critical challenges and improve healthcare delivery. In addition, it highlights the side of digital solutions in Africa differently based on lean management integrated before and after technologies in the medicines supply chain and are not focused on the healthcare sector overall; however, the results demonstrate the importance of implementing lean management with digital solutions. Integrating digital solutions into a lean-managed medicines supply chain holds considerable promise for African public hospitals aiming to improve healthcare delivery.