Evaluation and comparison of 11C-choline uptake and calcification in aortic and common carotid arterial walls with combined PET/CT

Katô, Katsuhiko; Schober, Otmar; Ikeda, Mitsuru; Schäfers, Michael; Ishigaki, Takeo; Kies, Peter; Naganawa, Shinji; Stegger, Lars

doi:10.1007/s00259-009-1152-7

Cited by 69 publications

(51 citation statements)

References 26 publications

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“…Labelled choline was not taken up into normal vascular wall, or purely calcified lesions, in a retrospective analysis of 93 male patients undergoing cancer imaging [101]. In ex vivo imaging of aortae of ApoE-deficient mice, [ 18 F]-fluorocholine uptake better correlated with fat staining and macrophage-positive areas than FDG [102].…”

Section: Alternative Strategies For Imaging Vascular Inflammationmentioning

confidence: 99%

Vascular imaging with positron emission tomography

Joshi

Rosenbaum

Bordes

et al. 2011

Journal of Internal Medicine

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Atherosclerosis is an inflammatory disease that causes most myocardial infarctions, strokes and acute coronary syndromes. Despite the identification of multiple risk factors and widespread use of drug therapies, it still remains a global health concern with associated costs. Although angiography is established as the gold standard means of detecting coronary artery stenosis, it does not image the vessel wall itself, reporting only on its consequences such as luminal narrowing and obstruction. MRI and computed tomography provide more information about the plaque structure, but recently positron emission tomography (PET) imaging using [ 18 F]-fluorodeoxyglucose (FDG) has been advocated as a means of measuring arterial inflammation. This results from the ability of FDG-PET to highlight areas of high glucose metabolism, a feature of macrophages within atherosclerosis, particularly in high-risk plaques. It is suggested that the degree of FDG accumulation in the vessel wall reflects underlying inflammation levels and that tracking any changes in FDG uptake over time or with drug therapy might be a way of getting an early efficacy readout for novel anti-atherosclerotic drugs. Early reports also demonstrate that FDG uptake is correlated with the number of cardiovascular risk factors and possibly even the risk of future cardiovascular events. This review will outline the evidence base, shortcomings and emerging applications for FDG-PET in vascular imaging. Alternative PET tracers and other candidate imaging modalities for measuring vascular inflammation will also be discussed.

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Section: Alternative Strategies For Imaging Vascular Inflammationmentioning

confidence: 99%

Vascular imaging with positron emission tomography

Joshi

Rosenbaum

Bordes

et al. 2011

Journal of Internal Medicine

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“…Uptake was demonstrated in structural wall alterations with and without calcifications but no uptake was found in vascular calcifications without additional structural vessel wall alteration [61]. Recent studies with 11 C-choline PET/CT have demonstrated that radiotracer uptake and calcification are only rarely colocalized and 11 C-choline has the potential to provide additive information about atherosclerotic plaques independent of calcification measurement [62]. However, such imaging procedures are not suitable for screening very large patient populations and an integrated approach of combining laboratory biomarkers to select patients for advanced imaging seems a promising strategy to detect vulnerable plaques before fatal cardiovascular events occur.…”

Section: Choline As An Integrated Biomarker Of Plaque Vulnerabilitymentioning

confidence: 99%

Choline in acute coronary syndrome: an emerging biomarker with implications for the integrated assessment of plaque vulnerability

Danne

Möckel

2010

Expert Review of Molecular Diagnostics

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“…Various both experimental and clinical studies have shown the reliability of 18 F-FDG PET/CT in imaging and quantifying macrophage-mediated inflammation in plaque (11)(12)(13). Other studies have targeted different pathophysiologic aspects of plaque including cell membrane proliferation or active mineral deposition using 11 C-choline or 18 F-sodium fluoride, respectively (14,15).…”

mentioning

confidence: 99%

Feasibility of ¹¹C-Acetate PET/CT for Imaging of Fatty Acid Synthesis in the Atherosclerotic Vessel Wall

Derlin¹,

Habermann²,

Lengyel³

et al. 2011

J Nucl Med

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Fatty acids are a common constituent of atherosclerotic plaque and may be synthesized in the plaque itself. Fatty acid synthesis requires acetyl-coenzyme-A (CoA) as a main substrate, which is produced from acetate. Currently, 11 C-acetate PET/CT is used for the evaluation of malignancies. There are no data concerning its potential for the characterization of atherosclerotic plaque. Therefore, the purpose of the present study was to examine the prevalence, distribution, and topographic relationship of arterial 11 C-acetate uptake and vascular calcification in major arteries. Methods: Thirty-six patients were examined by wholebody 11 C-acetate PET/CT. Tracer uptake in various arterial segments was analyzed both qualitatively and semiquantitatively by measuring the blood-pool-corrected standardized uptake value (target-to-background ratio). CT images were used to measure calcified plaque burden. Results: 11 C-acetate uptake was observed at 220 sites in 32 (88.8%) of the 36 study patients, and mean target-to-background ratio was 2.5 6 1.0. Calcified atherosclerotic lesions were observed at 483 sites in 30 (83.3%) patients. Sixty-four (29.1%) of the 220 lesions with marked 11 Cacetate uptake were colocalized with arterial calcification. However, only 13.3% of all arterial calcification sites demonstrated increased radiotracer accumulation. Conclusion: Our data indicate the feasibility of using 11 C-acetate PET/CT for imaging of fatty acid synthesis in the atherosclerotic vessel wall. This study provides a rationale to incorporating 11 C-acetate PET into further preclinical and clinical studies to obtain new insights into fatty acid synthesis in atherosclerotic lesions and to evaluate whether it may be used to monitor pharmacologic intervention with fatty acid synthase inhibitors.

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Evaluation and comparison of 11C-choline uptake and calcification in aortic and common carotid arterial walls with combined PET/CT

Cited by 69 publications

References 26 publications

Vascular imaging with positron emission tomography

Vascular imaging with positron emission tomography

Choline in acute coronary syndrome: an emerging biomarker with implications for the integrated assessment of plaque vulnerability

Feasibility of ¹¹C-Acetate PET/CT for Imaging of Fatty Acid Synthesis in the Atherosclerotic Vessel Wall

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Evaluation and comparison of 11C-choline uptake and calcification in aortic and common carotid arterial walls with combined PET/CT

Cited by 69 publications

References 26 publications

Vascular imaging with positron emission tomography

Vascular imaging with positron emission tomography

Choline in acute coronary syndrome: an emerging biomarker with implications for the integrated assessment of plaque vulnerability

Feasibility of 11C-Acetate PET/CT for Imaging of Fatty Acid Synthesis in the Atherosclerotic Vessel Wall

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Feasibility of ¹¹C-Acetate PET/CT for Imaging of Fatty Acid Synthesis in the Atherosclerotic Vessel Wall