Evaluation and comparison of biomarkers in heart failure

Murthy, K A Sudharshana; Hg, Ashoka; Aparna, A

doi:10.1016/j.ihj.2015.09.003

Cited by 14 publications

(12 citation statements)

References 14 publications

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“…(10) A large body of evidence from clinical and experimental studies demonstrated NT-proBNP as a precise mortality and morbidity predictor for HF. (29,30) Although PSP levels were significantly increased in patients with HF, the results were not correlated with NT-proBNP levels in the present study.…”

Section: Discussioncontrasting

confidence: 86%

Serum Presepsin Levels in Patients with Decompensated Heart Failure

Bıyık¹,

Çağlar²,

Işıksaçan³

2018

ejcm

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Recently, the soluble CD14 subtype; presepsin (PSP) has been suggested as a reliable marker for systemic inflammation, which has not been studied in decompensated heart failure (DHF) up to date. Our aim was to investigate plasma PSP levels and its diagnostic ability in patients with DHF. Methods: Fifty patients with DHF and 51 controls without HF were included in our study. Besides routine clinical and laboratory data, N-terminal prohormone of brain natriuretic peptide (NT-pro BNP) and PSP levels were measured in blood samples of all the participants. Results: PSP levels were significantly higher in patients with DHF than controls (1107.98 ± 1001.15 vs. 540.47 ± 526.9 pg / mL, p = 0.001). Cutoff value for PSP was 442 pg / mL to detect HF with 76% sensitivity, 62.7% specificity, 66.7% positive predictive value and 72.7% negative predictive value (CI: 0.975-1.000). The diagnostic accuracy of PSP for DHF was not superior to that of NT-pro BNP (AUC: 0.99 vs. 0.74) Conclusions: This preliminary study reveals that PSP levels are significantly elevated in patients with DHF but the diagnostic power of PSP for DHF is lower than NT-pro BNP. PSP may be a new marker for DHF.

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Section: Discussioncontrasting

confidence: 86%

Serum Presepsin Levels in Patients with Decompensated Heart Failure

Bıyık¹,

Çağlar²,

Işıksaçan³

2018

ejcm

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“…For myocardial zymography, lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine transaminase (ALT), serum creatine kinase isozyme (CK-MB), and hydroxybutyrate Dehydrogenase (HDBH) are the most studied myocardial zymography indicators in the clinic. The increased level of a single indicator has no strong directivity toward myocardial injury, but increased levels of multiple indicators can be used to accurately determine the severity of the injury and the effectiveness of clinical treatment [17,18,19]. Myocardial enzyme and protein levels in peripheral blood can reflect the degree of myocardial ischemic necrosis, and may provide clues for the search for NP-induced MF.…”

Section: Introductionmentioning

confidence: 99%

Effects of Long-term Nonylphenol Exposure on Myocardial Fibrosis and Cardiac Function in Rats

Liu

et al. 2021

Preprint

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Background: Myocardial fibrosis is a critical pathological basis for the poor prognosis of cardiovascular diseases. Studies have found that myocardial fibrosis is closely associated with exposure to environmental estrogens such as nonylphenol (NP), as a representative of environmental estrogens. The aim of this study was to examine the effects of NP chronic exposure on myocardial fibrosis as well as cardiac structure and function. Forty Sprague Dawley rats were randomly divided into four groups (n = 10): control group (C), low NP dose (0.4 mg/kg, L), medium NP dose (4 mg/kg, M), and high NP dose (40 mg/kg, H) groups. The NP dose groups were gavaged with NP for 180 days. Results: The NP level in the heart of the NP groups was significantly higher than those in the control group (F = 43.658, P < 0.001). Serum aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase isozyme (CK-MB), lactate dehydrogenase (LDH) and α-hydroxybutyrate dehydrogenase (α-HBDH) significantly increased in the NP groups compared with the control group (). Histopathological examination of the heart biopsy illustrates that in the medium and high NP groups, the fibrous connective tissue had a disordered and loose gridding shape, muscle fibers had fractured, and muscle fibers were loose with a widened gap. Extensive inflammatory cell infiltration and fibroblast proliferation in the myocardial interstitium were also found. With increasing NP dose, the degree of muscle fiber loosing and disorder became more significant in the NP treatment groups, and the collagen volume fraction (CVF) was higher than that in the control group (P < 0.01). Compared with the control group, the expression of collagen I and collagen III increased significantly in the medium and high NP groups (P < 0.05). The values of the systolic thickness of the left ventricular anterior wall (LVAWs), the diastolic thickness of the left ventricular posterior wall (LVPWd), the systolic thickness of the left ventricular posterior wall (LVPWs), and the left ventricular anterior wall (LVAWd) in the NP groups are were slightly lower than those in of the control group. The values of left ventricular end systolic dimensions (LVIDs) in the NP groups increased compared with the control group. Conclusions: Long-term NP exposure could lead to fibrosis in the rat myocardium, which is characterized by increased expressions of myocardial collagen I and collagen III, as well as elevated cardiac enzymes. In addition, the cardiac structure was affected and changes were observed in the thinner ventricular wall and as an enlarged ventricular cavity.

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“…A small prospective study from India investigated the correlations between cardiac biomarkers (including B-type natriuretic peptide, Tn-I, TNF-α, and CK-MB) and the prognosis in 60 heart failure patients diagnosed according to the Framingham criteria 26 . The results showed that B-type natriuretic peptide had excellent predictive value while CK-MB played no role in this population.…”

Section: Discussionmentioning

confidence: 99%

Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease

Tseng

et al. 2020

Sci Rep

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chau-chung Wu 13,14,16* & Jaw-Wen chen 6,7,16* this study aimed to investigate the prognostic value of high-sensitivity creatine kinase-myocardial band or fraction (hsCK-MB) in comparison with other well-established biomarkers including heart type-fatty acid binding protein (H-FABP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with stable coronary heart disease (SCHD). A total of 1,785 patients were enrolled and followed for 36 months. The primary outcome was all-cause mortality. The secondary outcomes included cardiovascular (CV) death, acute myocardial infarction (AMI), angina-related hospitalizations, and hospitalizations for heart failure. The all-cause mortality rate was significantly higher in the high hsCK-MB group compared to the low hsCK-MB group (4.64% vs. 1.88%, p = 0.0026). After adjusting for baseline covariates, there were no significant differences for the secondary outcomes. H-FABP (≥4.226 ng/mL) was the best predictor for all-cause mortality (HR = 2.68, 95% CI = 1.28-5.62, p = 0.009) and cV death (HR = 6.84, 95% CI = 1.89-22.14, p = 0.003). The high NT-proBNP group had a higher AMIrelated hospitalization rate (HR = 1.91, 95% CI = 1.00-3.65, p = 0.05). Neither the addition of hsCK-MB to any other markers nor combinations of the three markers improved the prognostic significance of CV outcomes. In conclusion, hsCK-MB was an independent predictor for all-cause mortality but not CV outcomes in patients with SCHD. Combination of hsCK-MB, H-FABP and NT-proBNP failed to improve the prognostic power for all-cause mortality or CV outcomes. In 2018, the World Health Organization reported that 17.9 million people die each year, an estimated 31% of all deaths worldwide, from cardiovascular diseases including coronary artery disease, cerebrovascular disease, rheumatic heart disease and other conditions. Furthermore, 85% of all cardiovascular deaths are due to heart attack and stroke, and 60% of cardiovascular deaths occur in low-income and middle-income countries. Diabetes mellitus, hypertension, dyslipidemia, tobacco use, physical inactivity and family history of premature coronary

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Evaluation and comparison of biomarkers in heart failure

Abstract: BNP and TNF-α are excellent predictors of mortality and morbidity in HF. Troponin-I and CRP have shown significance in predicting the outcome in HF. GGT, uric acid, and CK-MB play no role in predicting the severity and outcome in HF.

Cited by 14 publications

References 14 publications

Serum Presepsin Levels in Patients with Decompensated Heart Failure

Serum Presepsin Levels in Patients with Decompensated Heart Failure

Effects of Long-term Nonylphenol Exposure on Myocardial Fibrosis and Cardiac Function in Rats

Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease

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