Evaluation and importance of different types of inhaler device in patients with chronic obstructive lung disease

Öztürk, Can; Aldağ, Yağmur; Demirci, Nilgün Yılmaz

doi:10.5578/tt.54112

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…In a study of 180 COPD outpatients in Turkey, correct use of pMDI, Diskus®, HandiHaler® and Turbuhaler® DPIs, as measured by the rate of performing all steps of application without error, did not significantly differ ( p = 0.082). 104 In another observational study of almost 3000 COPD patients, over 60% could not perform a perfect inhalation in line with the device label, regardless of device type. Device-specific critical errors accounted for 15% of handling errors for Breezhaler®, 21% for Diskus®, 29% for HandiHaler®, 32% for Turbuhaler®, 44% for pMDI and 47% with Respimat®.…”

Section: Device Use In Practicementioning

confidence: 99%

What to consider before prescribing inhaled medications: a pragmatic approach for evaluating the current inhaler landscape

Lavorini

Janson

Braido

et al. 2019

Ther Adv Respir Dis

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Inhaled therapies are the cornerstone of treatment in asthma and chronic obstructive pulmonary disease, and there are a multitude of devices available. There is, however, a distinct lack of evidence-based guidance for healthcare providers on how to choose an appropriate inhaler. This review aims to summarise recent updates on topics related to inhaler choice, and to offer practical considerations for healthcare providers regarding currently marketed devices. The importance of choosing the right inhaler for the right patient is discussed, and the relative merits of dry powder inhalers, pressurised metered dose inhalers, breath-actuated pressurised metered dose inhalers, spacers and soft mist inhalers are considered. Compiling the latest studies in the devices therapy area, this review focuses on the most common types of handling errors, as well as the comparative rates of incorrect inhalation technique between devices. The impact of device-specific handling errors on inhaler performance is also discussed, and the characteristics that can impair optimal drug delivery, such as inhalation flow rate, inhalation volume and particle size, are compared between devices. The impact of patient perceptions, behaviours and problems with inhalation technique is analysed, and the need for appropriate patient education is also highlighted. The continued development of technology in inhaler design and the need to standardise study assessment, endpoints and patient populations are identified as future research needs. The reviews of this paper are available via the supplemental material section.

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Section: Device Use In Practicementioning

confidence: 99%

What to consider before prescribing inhaled medications: a pragmatic approach for evaluating the current inhaler landscape

Lavorini

Janson

Braido

et al. 2019

Ther Adv Respir Dis

View full text Add to dashboard Cite

show abstract

“…Patient Information Request Form: Designed in line with the literature, the form was composed of a total of 18 questions addressing patients' socio‐demographic and clinical characteristics (Işık et al, 2014; Öztürk et al, 2017; Şahin et al, 2014; Ünlü et al 2001).…”

Section: Methodsmentioning

confidence: 99%

“…Being the most widely used device for inhalation treatments, MDI is more preferable and popular because it is easy to use, time‐efficient, easy to transport, cheaper than other devices, includes more than one dose, shows its effects rapidly, and is used for most drugs in COPD treatment (Başlılar et al, 2018; Salvi et al, 2014). However, since these devices require a certain level of hand‐mouth coordination and mental ability, requiring complicated manoeuvres, it is emphasised that they are disadvantageous for their high rate of incorrect use (Ceylan et al, 2008; Işık et al, 2014; Press et al, 2012; Öztürk et al, 2017). Therefore, it is necessary for patients to use MDI correctly so that it can produce sufficient effect (Fink & Rubin, 2005).…”

Section: Introductionmentioning

confidence: 99%

The effect of repeated video‐training session on metered doseinhaler skills among individuals with COPD: Prospective randomised controlled study

Yıldız

Çeçen

Lafci

et al. 2021

Journal of Clinical Nursing

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Objective This study was undertaken to assess the effect of repeated video‐training sessions on the adequacy of metered‐dose inhaler (MDI) among individuals with COPD. Background MDI devices facilitate the use of inhalation drugs in COPD patients and have become ever more important over the years. However, this device requires a certain level of hand‐to‐mouth coordination and cognitive ability. Since it has a high risk of application errors, training in its use is important to treatment success. Design Randomised controlled trial. Methods This study was carried out from 1 February to 1 July 2017 with the participation of 40 COPD patients. The data were collected using a ‘Patient Information Request Form’ and an ‘MDI Skill Evaluation Form’. CONSORT checklist was used to report the current study. Results It was found that there was no significant difference between the experimental and control groups in terms of the mean scores of the 1st measurement (p > .05), though the mean scores of the 5th measurement were significantly higher in the experimental group (p < .001). In the 5th measurement, it was identified that the control group had ‘moderate’ adequacy (3.20 ± 1.6), while the experimental group had ‘satisfactory’ adequacy (8.70 ± 1.17), indicating that the patients in the experimental group made fewer mistakes and showed improved adequacy. Conclusion It was found that repeated video‐training sessions materially improved MDI skills. Relevance to clinical practice. Supporting the training on inhaler drug therapy with visual technological tools and regular checking of drug use will contribute to COPD management.

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Engineering Budesonide Microparticles for Enhancing Pulmonary Targeting: Validation through In Vivo Investigations

Kumar,

Verma,

Patel

et al. 2024

Part & Part Syst Charact

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The study aimed to develop and evaluate budesonide inhalation micro‐suspension to target inflammation in the lower trachea and bronchi. Initially, the slurry phase is prepared by dispersing the drug (0.25 and 0.5 mg ml−1) in the Water for Injection with polysorbate 80. The slurry is mixed with the aqueous phase comprising other excipients. The mixture is further subjected to the treatment with homogenizer. The prepared formulations are subjected to various physio‐chemical analysis like description, density, pH, osmolality, viscosity, shelf life, impurities, assay, particle size, etc. Andersen cascade impactor is used to estimate the aerodynamic performance. In vivo analysis is initiated with the induction of Asthma in Sprague Dawley rats by ovalbumin challenge intranasally and the treatment is given with the aid of a nebulizer. Lastly, the biochemical estimations are carried out in blood and bronchoalveolar lavage fluid (BALF). The lungs are also subjected to morphological and histological evaluations. The physio‐chemical and analytical examination indicated a stable formulation that is compliant with the standard guidelines. The D90 value of the test formulation is ≤4.5 µm. Cascade impactor evaluation estimated almost, 2–10% higher amount of budesonide reaching the target region as compared to the marketed product. Test formulation attenuated the manifestation of ovalbumin‐induced asthma through suppression of inflammatory cell count in blood and BALF, and modulation of Lactate dehydrogenase and Alkaline Phosphatase levels which is further confirmed by histopathological analysis. The formulated budesonide micro‐suspension demonstrated stability, safety, and efficient delivery to the target site.

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Evaluation and importance of different types of inhaler device in patients with chronic obstructive lung disease

Abstract: SUMMARY Evaluation and importance of different types of inhaler device in patients with

Cited by 5 publications

References 27 publications

What to consider before prescribing inhaled medications: a pragmatic approach for evaluating the current inhaler landscape

What to consider before prescribing inhaled medications: a pragmatic approach for evaluating the current inhaler landscape

The effect of repeated video‐training session on metered doseinhaler skills among individuals with COPD: Prospective randomised controlled study

Engineering Budesonide Microparticles for Enhancing Pulmonary Targeting: Validation through In Vivo Investigations

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