Evaluation and management of a child with short stature

Chiarelli, Francesco; Primavera, Marina; Mastromauro, Concetta

doi:10.23736/s0026-4946.20.05980-0

Cited by 7 publications

(7 citation statements)

References 41 publications

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“…Growth within the wide range of normative patterns is an indication of good general health (1), and monitoring growth is considered fundamental in evaluating child's health (2). Growth that is markedly lower than the normative range may lead to short stature (1) which may compromise the physical and psychological health of a child (2).…”

Section: Introductionmentioning

confidence: 99%

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Assessment and referral of patients with short stature by primary care physicians in the Arabian gulf region: Current perspectives from a regional survey

Kaplan

Amiri²,

Attia³

et al. 2022

Front. Pediatr.

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Children with short stature are frequently referred late to pediatric endocrinologists in the Arabian Gulf region. This is likely a contributing factor to late initiation of treatment despite current evidence suggesting that children with short stature have better outcomes with earlier treatment. This delay in referral could be due to a lack of identification or proper assessment of short stature by front-line physicians. To analyze the assessment and perception of short stature in this group of physicians, an expert group of pediatric endocrinologists developed and disseminated an anonymous online survey of 22 multiple choice questions amongst general pediatricians, pediatric subspecialists, and family medicine physicians in the Arabian Gulf region. Of the 640 respondents, 450 completed the survey (70.3% completion rate). While most surveyed physicians use the correct definition for short stature in children, only 24% reported a consistent use of a wall-mounted stadiometer. Of the respondents, 50% or less would consider referring clinical conditions other than growth hormone (GH) deficiency or idiopathic short stature, 41% would refer a child with short stature as soon as height dropped below the 5th percentile, 57% considered GH a treatment option for short stature, and only 60% consider GH treatment safe. The results of this survey demonstrate knowledge gaps in short stature assessment and referral that need to be addressed through education on short stature amongst target physicians, and lay groundwork for future recommendations to address those gaps in the Arabian Gulf region.

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Section: Introductionmentioning

confidence: 99%

“…Early detection of abnormal growth in childhood allows for timely intervention that may prevent excessive short stature in adulthood (2,3). Many studies of growth hormone (GH) therapy for different conditions showed that early initiation of treatment increases the likelihood of achieving the genetic height potential (4-7).…”

Section: Introductionmentioning

confidence: 99%

Assessment and referral of patients with short stature by primary care physicians in the Arabian gulf region: Current perspectives from a regional survey

Kaplan

Amiri²,

Attia³

et al. 2022

Front. Pediatr.

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“…2) According to the International Classification of Pediatric Endocrine Diagnosis, short stature may be idiopathic (in which no possible cause is identified), secondary to organ system disease (e.g., chronic kidney disease) or www.e-apem.org to environmental factors, or may arise from genetic mutations (primary short stature). 3)…”

Section: Introductionmentioning

confidence: 99%

Growth plate extracellular matrix defects and short stature in children

Saltarelli

Quarta

Chiarelli

2022

Ann Pediatr Endocrinol Metab

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Many etiological factors causing short stature have already been identified in humans. In the last few years, the advent of new techniques for the detection of chromosomal and molecular abnormalities has made it possible to better identify patients with genetic causes of growth failure. Some of these factors directly affect the development and growth of the skeleton, since they damage the epiphyseal growth plate, where linear growth occurs, influencing chondrogenesis. In particular, defects in genes involved in the organization and function of the growth plate are responsible for several well-known conditions with short stature. These genes play a pivotal role in various mechanisms involving the extracellular matrix, intracellular signaling, paracrine signaling, endocrine signaling, and epigenetic regulation. In this review, we will discuss the genes involved in extracellular matrix disorders. The identification of genetic defects in linear growth failure is important for clinicians and researchers in order to improve the care of children affected by growth disorders.

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“…3,4) This study mentioned International Classification of Pediatric Endocrine Diagnosis of short stature into 1A, 1B, and 1C. 5) Of these, 1A is a primary growth failure that consists of clinically defined syndromes (1A.1), small for gestational age with failure of catch-up growth (1A.2), and skeletal dysplasias (1A.3). 6) 1B is secondary growth failure due to insufficient nutrient intake (1B.1), disorders in organ systems other than skeletal (1B.2), growth hormone deficiency (1B.3), other disorders of the growth hormone-IGF axis (1B.4), other endocrine disorders associated with short stature (1B.5), metabolic disorders (1B.6), psychosocial disorders (1B.7), and iatrogenic causes of short stature (1B.8).…”

mentioning

confidence: 99%

“…This study mentioned International Classification of Pediatric Endocrine Diagnosis of short stature into 1A, 1B, and 1C [ 5 ]. Of these, 1A is a primary growth failure that consists of clinically defined syndromes (1A.1), small for gestational age with failure of catch-up growth (1A.2), and skeletal dysplasias (1A.3) [ 6 ].…”

mentioning

confidence: 99%

Commentary on “Growth plate extracellular matrix defects and short stature in children”

Kim

2022

Ann Pediatr Endocrinol Metab

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Evaluation and management of a child with short stature

Cited by 7 publications

References 41 publications

Assessment and referral of patients with short stature by primary care physicians in the Arabian gulf region: Current perspectives from a regional survey

Assessment and referral of patients with short stature by primary care physicians in the Arabian gulf region: Current perspectives from a regional survey

Growth plate extracellular matrix defects and short stature in children

Commentary on “Growth plate extracellular matrix defects and short stature in children”

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