Evaluation and Management of Genitourinary Emergencies in Patients with Cancer

Lipe, Demis N.; Mann, Phillip B.; Babakhanlou, Rodrick; Carreras, Maria Teresa Cruz; Hita, A. Guido; Wattana, Monica K.

doi:10.1155/2021/4511968

Cited by 1 publication

(2 citation statements)

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“…Radiotherapy and chemotherapy with select agents, including cyclophosphamide, ifosfamide, busulfan, idarubicin and carboplatin, as well as intravesicular treatment with a broader range of chemotherapeutics and HSCT conditioning regimens are causative. 107 Cessation of chemotherapeutic therapy usually resolves the bleeding in a few weeks once the bladder epithelium is restored. However, radiotherapy-induced hemorrhagic cystitis can persist for years due to scarring and fibrosis of the bladder lining.…”

Section: Table 3 (Continued)mentioning

confidence: 99%

“…Reactive oxygen species are the acute irritants that underlie hemorrhagic cystitis. Radiotherapy and chemotherapy with select agents, including cyclophosphamide, ifosfamide, busulfan, idarubicin and carboplatin, as well as intravesicular treatment with a broader range of chemotherapeutics and HSCT conditioning regimens are causative 107 . Cessation of chemotherapeutic therapy usually resolves the bleeding in a few weeks once the bladder epithelium is restored.…”

Section: Cytotoxic Chemotherapy and Radiotherapy Complicationsmentioning

confidence: 99%

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Oncologic emergencies and urgencies: A comprehensive review

Rothberg

Quest

Yeung

et al. 2022

CA A Cancer J Clinicians

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Patients with advanced cancer generate 4 million visits annually to emergency departments (EDs) and other dedicated, high‐acuity oncology urgent care centers. Because of both the increasing complexity of systemic treatments overall and the higher rates of active therapy in the geriatric population, many patients experiencing acute decompensations are frail and acutely ill. This article comprehensively reviews the spectrum of oncologic emergencies and urgencies typically encountered in acute care settings. Presentation, underlying etiology, and up‐to‐date clinical pathways are discussed. Criteria for either a safe discharge to home or a transition of care to the inpatient oncology hospitalist team are emphasized. This review extends beyond familiar conditions such as febrile neutropenia, hypercalcemia, tumor lysis syndrome, malignant spinal cord compression, mechanical bowel obstruction, and breakthrough pain crises to include a broader spectrum of topics encompassing the syndrome of inappropriate antidiuretic hormone secretion, venous thromboembolism and malignant effusions, as well as chemotherapy‐induced mucositis, cardiomyopathy, nausea, vomiting, and diarrhea. Emergent and urgent complications associated with targeted therapeutics, including small molecules, naked and drug‐conjugated monoclonal antibodies, as well as immune checkpoint inhibitors and chimeric antigen receptor T‐cells, are summarized. Finally, strategies for facilitating same‐day direct admission to hospice from the ED are discussed. This article not only can serve as a point‐of‐care reference for the ED physician but also can assist outpatient oncologists as well as inpatient hospitalists in coordinating care around the ED visit.

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Section: Table 3 (Continued)mentioning

confidence: 99%

Section: Cytotoxic Chemotherapy and Radiotherapy Complicationsmentioning

confidence: 99%