Evaluation and Management of the Infant Exposed to HIV-1 in the United States

Havens, Peter L.; Mofenson, Lynne

doi:10.1542/peds.2008-3076

Cited by 45 publications

(16 citation statements)

References 72 publications

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“…P p .486 CPP has been proposed for use in highrisk infants in Western countries [4][5][6]. Concerns include possible increased toxicity and occurrence of viral resistance in infected infants [4].…”

Section: Use Of Post-natal Antiretroviral Prophylaxis For Prevention mentioning

confidence: 99%

Use of Post‐Natal Antiretroviral Prophylaxis for Prevention of Mother‐to‐Child Transmission of HIV Is Increasing in Italy

et al. 2009

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Section: Use Of Post-natal Antiretroviral Prophylaxis For Prevention mentioning

confidence: 99%

Use of Post‐Natal Antiretroviral Prophylaxis for Prevention of Mother‐to‐Child Transmission of HIV Is Increasing in Italy

et al. 2009

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“…Willingness to be tested for HIV Early identification of HIV infected pregnant women enables health care providers to test infants for HIV infection following delivery, as well as for the early administration of prophylaxis to protect HIVinfected infants and those whose HIV status remains unknown from opportunistic infections. It also allows an opportunity for counseling women on the risks of infant infection via breastfeeding and proper initiation of appropriate replacement feeding [15,26] . Testing early in the pregnancy has several advantages over testing in late stages of pregnancy.…”

Section: Advantages Of Testing For Hiv During Pregnancymentioning

confidence: 99%

Women’s willingness to be tested for human immunodeficiency virus during pregnancy: A review

Ben-Natan

Hazanov

2015

WJV

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not receive prevention services. HIV testing of pregnant women is considered to be one of the key strategies for preventing mother-to-child-transmission of HIV, but HIV testing rates among pregnant women in various countries remain suboptimal. Understanding the factors relating to women's willingness to be tested for HIV during pregnancy is critical for developing strategies to increase HIV testing rates among pregnant women. Extensive research points to various factors relating to women's willingness to be tested for HIV during pregnancy, and various recommendations aimed at improving testing rates among pregnant women have been suggested based on the research. In light of the goals set by the United Nations to reduce the rate of infants infected with HIV, it is necessary to summarize what is currently known regarding factors related to women's willingness to be tested for HIV during pregnancy. The purpose of this review is therefore to examine factors related to women's willingness to be tested for HIV during pregnancy, and to summarize recommendations for practice and further research. Core tip: The willingness of women to be tested for human immunodeficiency virus (HIV) during pregnancy is a complex phenomenon. There is frequent inconsistence in research results; however, studies have shown that certain major factors are steadily identified over time as associated with the phenomenon. Numerous factors related to pregnant women's willingness to be tested suggest multiple possible interventions to maximize HIV testing efficiency and increase testing rates. There is a need in further research of the phenomenon, as the majority of the research literature focuses on sub-Saharan Africa.Women's willingness to be tested for human immunodeficiency virus during pregnancy: A review Ben-Natan M, Hazanov Y. Women's willingness to be tested for human immunodeficiency virus during pregnancy: A review.

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“…The current standard of care is to start the newborn on ART while performing DNA NAT at 2 and 4 weeks of age, with two negative test results being a confirmation of no transmission [44]. Frequent monitoring would be needed for breastfeeding infants since transmission can occur through breast milk [45].…”

Section: Infant and Acute Infection Testingmentioning

confidence: 99%

HIV Diagnostics: Challenges and Opportunities

Wong

Hewlett

2010

HIV Ther.

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Accurate HIV diagnostic testing continues to pose challenges, but there are also opportunities for assay performance improvements in key areas for specific intended-use settings. The genetic diversity of HIV can result in false and discordant results in assays that fail to detect new variant strains. The use of antiretroviral therapies has resulted in drug-resistant variants that require monitoring by sequencing and genotyping methods. Nucleic acid testing is the most sensitive and reliable platform for detection, but it is costly and limited to centralized testing facilities, making implementation difficult in resource-limited settings where HIV has hit the hardest. Rapid antibody tests suitable for point-of-care use are becoming more accessible in resource-limited settings, but these tests may not detect HIV during the acute infection stage. Emerging antigen/antibody combination assays are viable alternatives to nucleic acid testing for diagnosis of recent infections. Although patient monitoring (e.g., via CD4+ T-cell count and viral load determination) and infant diagnoses still rely on clinical laboratory-based testing, point-of-care options are being developed. There are other technical challenges to HIV diagnostic testing and emerging biodetection technologies that may be able to address them, but they are not yet proven.

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Evaluation and Management of the Infant Exposed to HIV-1 in the United States

Cited by 45 publications

References 72 publications

Use of Post‐Natal Antiretroviral Prophylaxis for Prevention of Mother‐to‐Child Transmission of HIV Is Increasing in Italy

Use of Post‐Natal Antiretroviral Prophylaxis for Prevention of Mother‐to‐Child Transmission of HIV Is Increasing in Italy

Women’s willingness to be tested for human immunodeficiency virus during pregnancy: A review

HIV Diagnostics: Challenges and Opportunities

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