Evaluation and Optimization of Paper-Based SERS Substrate for Potential Label-Free Raman Analysis of Seminal Plasma

Huang, Zufang; Cao, Gang; Sun, Yan; Du, Shengrong; Li, Yongzeng; Feng, Shouhua; Lin, Juqiang; Lei, Jinping

doi:10.1155/2017/4807064

Cited by 11 publications

(9 citation statements)

References 39 publications

(43 reference statements)

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“…1 ]. Several recent studies have demonstrated the utility of different approaches for improving the loading (e.g., prior soaking of paper in NaCl, Glycidyl-trimethyl-ammonium chloride (GTAC)] 85,86 . The advantage of dip coating/immersion method is its ability to deposit NPs with different shapes, sizes, and compositions on the paper 87−89 .…”

Section: Paper-based Sers Substratesmentioning

confidence: 99%

Flexible SERS substrates for hazardous materials detection: recent advances

Moram¹,

Soma²

2021

OEA

163

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This article reviews the most recent advances in the development of flexible substrates used as surface-enhanced Raman scattering (SERS) platforms for detecting several hazardous materials (e.g., explosives, pesticides, drugs, and dyes). Different flexible platforms such as papers/filter papers, fabrics, polymer nanofibers, and cellulose fibers have been investigated over the last few years and their SERS efficacies have been evaluated. We start with an introduction of the importance of hazardous materials trace detection followed by a summary of different SERS methodologies with particular attention on flexible substrates and their advantages over the nanostructures and nanoparticle-based solid/hybrid substrates. The potential of flexible SERS substrates, in conjunction with a simple portable Raman spectrometer, is the power to enable practical/on-field/point of interest applications primarily because of their low-cost and easy sampling.

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Section: Paper-based Sers Substratesmentioning

confidence: 99%

Flexible SERS substrates for hazardous materials detection: recent advances

Moram¹,

Soma²

2021

OEA

163

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“…The time of soaking was ∼30 min uniformly for all of the substrates studied. However, this time also affects the loading of NPs and has been studied extensively by Huang et al, 58 wherein they observed that soaking for 1 h procured excellent SERS results. The absorption of NPs on a substrate will enhance the EM field in sensing because of its ability achieved through the excitation of LSPR.…”

Section: Experimental Detailsmentioning

confidence: 99%

Ag/Au Nanoparticle-Loaded Paper-Based Versatile Surface-Enhanced Raman Spectroscopy Substrates for Multiple Explosives Detection

et al. 2018

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We present a systematic study on the fabrication, characterization of versatile, and low-cost filter paper-based surface-enhanced Raman spectroscopy (SERS) substrates loaded with salt-induced aggregated Ag/Au nanoparticles (NPs). These were demonstrated as efficient SERS substrates for the detection of multiple explosive molecules such as picric acid (5 μM), 2,4-dinitrotoluene (1 μM), and 3-nitro-1,2,4-triazol-5-one (10 μM) along with a common dye molecule (methylene blue, 5 nM). The concentrations of the dye and explosive molecules in terms of mass represent 31.98 pg, 11.45 ng, 1.82 ng, and 13.06 ng, respectively. Silver (Ag) and gold (Au) colloidal NPs were prepared by femtosecond laser (∼50 fs, 800 nm, 1 kHz) ablation of Ag/Au-target immersed in distilled water. Subsequently, the aggregated nanoparticles were achieved by mixing the pure Ag and Au NPs with different concentrations of NaCl. These aggregated NPs were characterized by UV–visible absorption and high-resolution transmission electron microscopy techniques. The SERS substrates were prepared by soaking the filter paper in aggregated NPs. The morphologies of the paper substrates were investigated using field-emission scanning electron microscopy technique. We have achieved superior enhancements with high reproducibility and sensitivity for filter paper substrates loaded with Ag/Au NPs mixed for an optimum concentration of 50 mM NaCl.

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“…Example of how characteristic ET bands (highlighted with grey areas) are observed in LF‐SERS spectra of a variety of human biofluids of healthy donors. SERS spectrum of (a) ET [19] is compared to SERS spectra of (b) erythrocytes lysate [19], (c) serum [29], (d) gingival crevicular fluid [28], (e) seminal plasma [50] and (f) cerebrospinal fluid [32]. All spectra were obtained with an excitation at 785 nm, and using Ag nanoparticles as substrates, with the exception of (f), for which Au nanoparticles were used.…”

Section: Et In Lf‐sers Of Biofluidsmentioning

confidence: 99%

“…Spectral data of (e) and (f) were obtained from fig. 2d in [50] and fig. 4A in [32], respectively, by using the open software web plot digitalizer [57].…”

Section: Et In Lf‐sers Of Biofluidsmentioning

confidence: 99%

The key role of ergothioneine in label‐free surface‐enhanced Raman scattering spectra of biofluids: a retrospective re‐assessment of the literature

Fornasaro

Sergo

2022

FEBS Letters

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Label-free surface-enhanced Raman scattering (SERS) has recently gained attention in the field of liquid biopsy as a rapid and relatively inexpensive technique that could significantly ease clinical diagnosis and prognosis by investigating a biofluid sample with a laser. Indeed, SERS spectra provide information about a set of metabolites present in the analysed biofluid, thereby offering biochemical insight into specific health conditions. Ergothioneine plays a key role since it is one of the few metabolites in biofluids that are detectable by label-free SERS. In the past decade, many studies characterizing biofluids or other biological samples have unknowingly linked this amino acid with crucial metabolic processes, including inflammation, in a plethora of diseases. However, since the SERS spectrum of ergothioneine has been reported only recently, most past studies inadvertently assigned what are now recognized as the spectral features of this compound to other molecules. The purpose of the present review is to summarize and re-evaluate these studies in the light of the recent SERS characterization of ergothioneine so as to better recognize the role of ergothioneine in many clinical conditions.

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Evaluation and Optimization of Paper-Based SERS Substrate for Potential Label-Free Raman Analysis of Seminal Plasma

Cited by 11 publications

References 39 publications

Flexible SERS substrates for hazardous materials detection: recent advances

Flexible SERS substrates for hazardous materials detection: recent advances

Ag/Au Nanoparticle-Loaded Paper-Based Versatile Surface-Enhanced Raman Spectroscopy Substrates for Multiple Explosives Detection

The key role of ergothioneine in label‐free surface‐enhanced Raman scattering spectra of biofluids: a retrospective re‐assessment of the literature

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