Evaluation and treatment of anosmia

Retronasal olfactory function in nasal polyposis

“…At least 25% of all anosmias are caused by the presence of sinonasal disease 4–6 . In contrast with other major causes of smell impairments (head trauma, olfactory loss after infections of the upper respiratory tract), NP is treatable, and olfactory dysfunction is potentially reversible 7,8 . Olfactory loss in sinonasal disease typically occurs gradually over the course of years.…”

Lipoic Acid in the Treatment of Smell Dysfunction Following Viral Infection of the Upper Respiratory Tract

“… 2,6–8 This difficult situation is underlined by the fact that, when “parosmia”/“troposmia” (distorted olfactory sensations elicited through odors) is present, 9,10 in some patients surgical removal of the olfactory epithelium may be considered as a cure. 11 …”

“…2,6 -8 This difficult situation is underlined by the fact that, when "parosmia"/"troposmia" (distorted olfactory sensations elicited through odors) is present, 9,10 in some patients surgical removal of the olfactory epithelium may be considered as a cure. 11 When searching for potential candidates for the pharmacological treatment of olfactory dysfunction we came across ␣-lipoic acid (aLA), which is used in the treatment of diabetic neuropathy. [12][13][14][15] The effect of aLA is well described both in experimental animals and in humans (for review see Packer et al 16 ).…”

Pathology of the Olfactory Nerve

“…4). [11][12][13][14] In addition, respiratory problems may prevent airflow to the olfactory cleft, thus producing olfactory loss. More recently, localized inflammation of the olfactory cleft with consecutive thickening of the mucosa is described as a possible cause of olfactory loss.…”