Evaluation and Treatment of Tinnitus

Paiva, Scheila Farias de

doi:10.15406/joentr.2017.06.00186

JOENTR

2017

DOI: 10.15406/joentr.2017.06.00186

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Evaluation and Treatment of Tinnitus

Scheila Farias de Paiva¹

Abstract: IncidenceCitation: Paiva SF, Aragão IPS, Sampaio ATS, Santos MEH, Santana FRT (2017) Evaluation and Treatment of Tinnitus. J Otolaryngol ENT Res 6(6): 00186.

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2021

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Effectiveness of Tinnitan Duo® in Subjective Tinnitus with Emotional Affectation: A Prospective, Interventional Study

Knäpper

Girauta

Coromina

2021

Journal of Dietary Supplements

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To assess the effectiveness of a food supplement (Tinnitan Duo V R ) containing 5-hydroxytryptophan, Ginkgo biloba, magnesium, melatonin, vitamin B5 and B6, and zinc at improving tinnitus response and intensity. Prospective, single-center interventional study including patients with subjective tinnitus and emotional affectation. The primary endpoint was the change in the Tinnitus Handicap Inventory (THI) total score and the emotional subscale after 3 months of treatment. Secondary endpoints were the change from baseline to month 3 in (1) the Tinnitus Distress Rating (TDR) scale, and (2) in hearing status, and the safety profile of patients throughout the study. Sixtyone patients were included, and 29 completed the study. The THI total score was significantly reduced after 3 months of treatment in the per-protocol (PP, all the patients with no major protocol deviations) and intention-to-treat (ITT) populations (À15.7 and À7.5, respectively; p ¼ 0.001). The emotional subscale score significantly decreased after 3 months of treatment by À5.6 in the PP (p ¼ 0.001) and by À2.6 in the ITT populations (p ¼ 0.001). Perceived tinnitus loudness significantly decreased after 3 months of treatment (p ¼ 0.001). The audiogram showed no significant changes in hearing status after 3 months of treatment. Of the five adverse events (AEs) reported, all were mild or moderate, and three were related to the study treatment (two headaches and one dizziness). This new food supplement was associated with an improved tinnitus-related emotional affectation and with a good safety profile.

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Effectiveness of Tinnitan Duo® in Subjective Tinnitus with Emotional Affectation: A Prospective, Interventional Study

Knäpper

Girauta

Coromina

2021

Journal of Dietary Supplements

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Evaluation and Treatment of Tinnitus

Abstract: IncidenceCitation: Paiva SF, Aragão IPS, Sampaio ATS, Santos MEH, Santana FRT (2017) Evaluation and Treatment of Tinnitus. J Otolaryngol ENT Res 6(6): 00186.

Cited by 1 publication

References 12 publications

Effectiveness of Tinnitan Duo® in Subjective Tinnitus with Emotional Affectation: A Prospective, Interventional Study

Effectiveness of Tinnitan Duo® in Subjective Tinnitus with Emotional Affectation: A Prospective, Interventional Study

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