Evaluation and Utilization as a Public Health Tool of a National Molecular Epidemiological Tuberculosis Outbreak Database within the United Kingdom from 1997 to 2001

Drobniewski, Francis; Gibson, Andrea L.; Ruddy, Michael C.; Yates, M.D.

doi:10.1128/jcm.41.5.1861-1868.2003

Cited by 16 publications

(18 citation statements)

References 48 publications

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“…9 The recent outbreaks in North London, Leicester and Wales highlight that TB is still a problem in the UK. [10][11][12] Currently, in the UK there are approximately 6700 cases of clinical TB per annum, with varying geography. This represents a rate of 12.4 per 100,000 population (England, 13.0; Wales, 6.3; Northern Ireland, 3.3).…”

Section: Tuberculosis In the Ukmentioning

confidence: 99%

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Dinnes¹,

Deeks²,

Kunst³

et al. 2007

Health Technol Assess

538

361

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment ProgrammeT he Health Technology Assessment (HTA) programme, now part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the costs, effectiveness and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care. The research findings from the HTA Programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA Programme is needs-led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in the NHS, the public and consumer groups and professional bodies such as ...

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Section: Tuberculosis In the Ukmentioning

confidence: 99%

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Dinnes¹,

Deeks²,

Kunst³

et al. 2007

Health Technol Assess

538

361

View full text Add to dashboard Cite

show abstract

“…The major burden is borne by underdeveloped nations. However, even in settings with excellent public health and clinical facilities, sporadic outbreaks of tuberculosis remain a continuing threat (7,23).In 2001 the largest recognized outbreak of tuberculosis in a United Kingdom school was detected in Leicester. The index patient was a 14-year-old student who had been complaining of a chronic cough for 9 months prior to being diagnosed with sputum smear-positive cavitary pulmonary tuberculosis (9).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Use of Genome Level-Informed PCR as a New Investigational Approach for Analysis of Outbreak-Associated Mycobacterium tuberculosis Isolates

et al. 2004

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Mycobacterium tuberculosis strain CH, the index isolate linked to a major tuberculosis outbreak associated with high levels of transmissibility and virulence, was characterized by microarray analysis by use of a PCR product array representative of the genome of M. tuberculosis strain H37Rv. Seven potential genomic deletions were identified in CH, five of which were confirmed by PCR analysis across the predicted deletion points. The panel of five PCRs required to individually interrogate these loci was collectively referred to as the genome level-informed PCR (GLIP) assay. GLIP analysis was performed with CH, 12 other epidemiologically linked isolates, and 43 recent, non-outbreak-associated isolates derived from patients within the local area. All 13 outbreak-linked isolates showed a profile corresponding to the presence of all five deletions. These 13 isolates were also found to share common variable-number tandem repeat and mycobacterial interspersed repetitive unit profiles. None of the 43 non-outbreak-associated isolates exhibited the five-deletion profile. Although three individual deletions were present in upwards of 44% of the non-outbreak-associated isolates, no single-deletion isolates were detected. Interestingly, none of these deletions had been previously recognized, and sequence analysis of the immediate flanking regions in CH failed to identify a likely mechanism of deletion for four of the five loci. The GLIP assay also proved valuable in ongoing surveillance of the outbreak, rapidly identifying a further two outbreak-associated cases months after the initial cluster and, importantly, dismissing a further 12 epidemiologically suspect cases, which allowed the optimum deployment of public health resources.Mycobacterium tuberculosis remains a major killer, accounting for more than 2 million deaths annually. Its success as a pathogen is highlighted by its remarkable ability to spread among human populations. It is estimated that more than 2 billion people, a third of the world's population, are infected with this bacterium (29). The major burden is borne by underdeveloped nations. However, even in settings with excellent public health and clinical facilities, sporadic outbreaks of tuberculosis remain a continuing threat (7,23).In 2001 the largest recognized outbreak of tuberculosis in a United Kingdom school was detected in Leicester. The index patient was a 14-year-old student who had been complaining of a chronic cough for 9 months prior to being diagnosed with sputum smear-positive cavitary pulmonary tuberculosis (9). Subsequent screening and investigation by the health authority of the entire school population led to the diagnosis of a further 77 cases of active disease and 254 cases of latent tuberculosis among students, staff, and family contacts of the index patient and secondary cases. This outbreak occurred in Leicester, a city with rates of tuberculosis exceeding four times the national average (24; P. Monk, unpublished data). Given the large scale of the outbreak and the elevated rates of tu...

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“…They identified various infectious chains of contact that, starting in a bar that played the role of a turntable, moved out rapidly into several areas such as housing for homeless men and alcoholics and a tank-cleaning firm.This study can be considered as a model because it combines detailed clinical and epidemiological data and phenotypical and molecular studies. Nowadays, numerous outbreaks continue to be identified in various public areas such as hospitals, schools, bars, prisons, nursing homes, and homeless shelters in developed and developing countries [38,52,90,92,105,116,120,153,159,178]. These studies were also able to identify risk factors for TB transmission.…”

Section: Clinical and Epidemiological Relevance Of Molecular Epidemiomentioning

confidence: 72%

“…These databases should be accessible online and interactive in order to provide access to all clinicians and researchers so they can compare their data.They could be constructed on the model of nucleic acid or protein databases such as GenBank (http://www.ncbi.nlm.nih.gov/Genbank/index.html) or EBI (http://www.ebi.ac.uk/), which allow researchers to submit, consult, and analyze sequence data.To succeed, several conditions are needed: (i) the definition of standardized methodologies for data exploitation, (ii) the development of a completely disinterested structure that is updated frequently and that will avoid publication pressure and scientific competition, and (iii) the validation of data in order to prevent errors.This type of database may be a powerful public health tool to follow the evolution of TB from a drug resistance or epidemiological point of view at an international level. Several publications have shown the usefulness of databases: Drobniewski et al [52], Filliol et al [60], Zozio et al [219], and NiobeEyangoh et al [133].…”

Section: Urgent Needs For Tb Control and Molecular Epidemiologymentioning

confidence: 99%

Pulmonary Tuberculosis and Mycobacterium Tuberculosis: Modern Molecular Epidemiology and Perspectives

Godreuil

Tazi

Bañuls³

2006

Encyclopedia of Infectious Diseases

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Evaluation and Utilization as a Public Health Tool of a National Molecular Epidemiological Tuberculosis Outbreak Database within the United Kingdom from 1997 to 2001

Cited by 16 publications

References 48 publications

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Use of Genome Level-Informed PCR as a New Investigational Approach for Analysis of Outbreak-Associated Mycobacterium tuberculosis Isolates

Pulmonary Tuberculosis and Mycobacterium Tuberculosis: Modern Molecular Epidemiology and Perspectives

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