Évaluation de la fibrose dans les hépatites chroniques virales B : comparaison entre la biopsie hépatique et l’élastométrie (Fibroscan®)

Diallo, I.; Mbaye, P. S.; Vray, Muriel; Ndiaye, B.; Diop, Y.; Simon, François; Fall, Fatou

doi:10.1007/s12157-016-0663-7

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…In our population 45.88% had minimal or non-significant fibrosis, 54.12% had significant fibrosis. The results are variable in the literature depending on the cohorts Diallo I et al (Senegal 2016) found 57.14% of non-significant fibrosis and 42.86% of significant fibrosis [22] while Touré Ps et al (Senegal 2016) found 89.9% of non-significant fibrosis, 10.1% of significant fibrosis [10].…”

Section: Discussionmentioning

confidence: 97%

Correlation between Ultrasound Aspects of Fibrosis and Fibroscan Outcomes of Patients with Chronic Hepatitis B Virus

Tiemtore-Kambou,

Koama,

Guingane

et al. 2023

OJRad

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Background: The assessment of liver fibrosis is an essential part of the follow-up of patients with chronic HBV. Ultrasound and fibroscan are two commonly used non-invasive examinations and the purpose of this study is to assess the correlation between the results of these two examinations in the assessment of liver fibrosis. Methodology: This was a descriptive and analytical cross-sectional study with retrospective collection over a period of 30 months from January 01, 2018 to June 30, 2020 on the correlation between the ultrasound aspects and the results of the fibroscan of patients with chronic carriers of Hepatitis B virus at the Teaching Hospital of Bogodogo and at the faith-based health center CANDAF. Results: A total of 85 patients with fibrosis were collected. The 30 -40 age group was the most represented (41.18%), with a male predominance of 52.94%. The patients with a married life were the most represented (77.64%), the social stratum the most represented were the middle managers (32.94%). University level was predominant among education levels (45.64%). The personal history was traditional circumcision (34.12%), excision (21.18%), manicure (16.47%). The circumstances of the findings were blood donation (34.12%), screening (21.18%), fortuitous findings (16.47%). The association between echostructure and fibrosis on the fibroscan scan was significant (homogeneous hyperechoic echostructure p = 0.

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Section: Discussionmentioning

confidence: 97%

Correlation between Ultrasound Aspects of Fibrosis and Fibroscan Outcomes of Patients with Chronic Hepatitis B Virus

Tiemtore-Kambou,

Koama,

Guingane

et al. 2023

OJRad

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Systematic review and individual-patient-data meta-analysis of non-invasive fibrosis markers for chronic hepatitis B in Africa

et al. 2023

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In sub-Saharan Africa, simple biomarkers of liver fibrosis are needed to scale-up hepatitis B treatment. We conducted an individual participant data meta-analysis of 3,548 chronic hepatitis B patients living in eight sub-Saharan African countries to assess the World Health Organization-recommended aspartate aminotransferase-to-platelet ratio index and two other fibrosis biomarkers using a Bayesian bivariate model. Transient elastography was used as a reference test with liver stiffness measurement thresholds at 7.9 and 12.2kPa indicating significant fibrosis and cirrhosis, respectively. At the World Health Organization-recommended cirrhosis threshold (>2.0), aspartate aminotransferase-to-platelet ratio index had sensitivity (95% credible interval) of only 16.5% (12.5–20.5). We identified an optimised aspartate aminotransferase-to-platelet ratio index rule-in threshold (>0.65) for liver stiffness measurement >12.2kPa with sensitivity and specificity of 56.2% (50.5–62.2) and 90.0% (89.0–91.0), and an optimised rule-out threshold (<0.36) with sensitivity and specificity of 80.6% (76.1–85.1) and 64.3% (62.8–65.8). Here we show that the World Health Organization-recommended aspartate aminotransferase-to-platelet ratio index threshold is inappropriately high in sub-Saharan Africa; improved rule-in and rule-out thresholds can optimise treatment recommendations in this setting.

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Évaluation de la fibrose dans les hépatites chroniques virales B : comparaison entre la biopsie hépatique et l’élastométrie (Fibroscan®)

Cited by 2 publications

References 13 publications

Correlation between Ultrasound Aspects of Fibrosis and Fibroscan Outcomes of Patients with Chronic Hepatitis B Virus

Correlation between Ultrasound Aspects of Fibrosis and Fibroscan Outcomes of Patients with Chronic Hepatitis B Virus

Systematic review and individual-patient-data meta-analysis of non-invasive fibrosis markers for chronic hepatitis B in Africa

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