Évaluation des performances de trois techniques de détection et de typage des papillomavirus humains : Hybrid Capture® 2, HPV Consensus kit® et Amplicor HPV®

Hantz, Sébastien; Caly, H.; Decroisette, E.; Dutrop, A.; Bakeland, D.; Pascal, Blaise; Darreye, G.; Dussartre, C.; Renaudie, J.; Aubard, Y.; Denis, F.; Alain, Sophie

doi:10.1016/j.patbio.2007.09.006

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…The detection of high-risk HPV DNA is thought to be useful in supplementing an abnormal cytological result [29, 30] and that in women with ASCUS, the presence of an HPV-positive group can substantially increase the chances of finding CIN II/III and cervical cancer, even though in the majority of these women significant lesions are not found [6]. Therefore, some authors recommend that testing for HPV DNA be performed on women with ASCUS [15, 31], while a biopsy guided by colposcopy is only recommended if high-risk HPV is present, while other women are treated more conservatively [5].…”

Section: Discussionmentioning

confidence: 99%

Atypical Squamous Cells of Undetermined Significance: Bethesda Classification and Association with Human Papillomavirus

Barcelos¹,

Michelin

Adad³

et al. 2011

Infectious Diseases in Obstetrics and Gynecology

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Introduction. To analyze patients with atypical squamous cells of undetermined significance (ASCUS) through a cytology review and the presence of microbiological agents, with consideration of colposcopy and semiannual tracking. Methods. 103 women with ASCUS were reviewed and reclassified: normal/inflammatory, ASCUS, low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL). If ASCUS confirmed, it was subclassified in reactive or neoplastic ASCUS, ASC-US, or ASC-H; and Regione Emilia Romagna Screening Protocol. Patients underwent a colposcopic examination, and test for Candida sp., bacterial vaginosis, Trichomonas vaginalis, and human papillomavirus (HPV) were performed. Results. Upon review, ASCUS was diagnosis in 70/103 (67.9%), being 38 (54.2%) reactive ASCUS and 32 (45.71%) neoplastic ASCUS; 62 (88.5%) ASC-US and 8 (11.41%) ASC-H. ASCUS (Regione Protocol), respectively 1-5: 15 (21.4%), 19 (27.1%), 3 (27.1%), 16 (22.8%), and 1 (1.4%). A higher number of cases of cervical intraepithelial neoplasia (CIN) II/III in the biopsies of patients with ASC-H compared to ASC-US (P = .0021). High-risk HPV test and presence of CIN II/III are more frequent in ASC-H than ASC-US (P = .031). Conclusions. ASC-H is associated with clinically significant disease. High-risk HPV-positive status in the triage for colposcopy of patients with ASC-US is associated with increased of CIN.

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Section: Discussionmentioning

confidence: 99%

Atypical Squamous Cells of Undetermined Significance: Bethesda Classification and Association with Human Papillomavirus

Barcelos¹,

Michelin

Adad³

et al. 2011

Infectious Diseases in Obstetrics and Gynecology

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Human papillomavirus and head and neck squamous cell carcinomas in the South-East of France: prevalence, viral expression, and prognostic implications

Gavid¹,

Pillet

Pozzetto

et al. 2013

Acta Oto-Laryngologica

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HPV DNA tested positive in 11.5% of biopsy samples. The HPV prevalence was higher in OSCCs (91.3 vs 27.3, p < 0.0001) and in patients not consuming tobacco (65.2% vs 95.4%, p < 0.0001). The estimated 3-year overall survival rates were 67.0% for HPV-infected patients versus 39.9% for non-infected patients. The high-risk HPV 16 was the most common type detected (65.2%). In 12 of 18 patients exhibiting DNA of high-risk HPV in their tumor tissue, the same viral genome was also present in normal tissue. E6 and E7 expression was found in 9 of 14 tumoral biopsies tested for these markers.

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Évaluation des performances de trois techniques de détection et de typage des papillomavirus humains : Hybrid Capture® 2, HPV Consensus kit® et Amplicor HPV®

Cited by 2 publications

References 15 publications

Atypical Squamous Cells of Undetermined Significance: Bethesda Classification and Association with Human Papillomavirus

Atypical Squamous Cells of Undetermined Significance: Bethesda Classification and Association with Human Papillomavirus

Human papillomavirus and head and neck squamous cell carcinomas in the South-East of France: prevalence, viral expression, and prognostic implications

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