Évaluation du succès de l’interruption volontaire de grossesse médicamenteuse par un seuil d’hCG sérique

Vitrant, Elise; Rolland, A.-L.; Kyheng, Maéva; Delepine, Juliette; Bardiaux, Laura; Parent, Claire; Baffet, Hortense; Catteau-Jonard, Sophie; Robin, Geoffroy

doi:10.1016/j.gofs.2021.10.013

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…The same results were also obtained in our study. Several studies have shown that the success rate of medication abortion correlates with the level of plasma HCG [27,28]. A similar phenomenon was observed in this study, the HCG level of patients in the control group after treatment were signi cantly higher than in femoston group, which was consistent with the higher failure rate in the control group.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of different doses of Femoston therapy for incomplete abortion: A prospective observational trial

Huang

Gong

Cai

et al. 2023

Preprint

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Background Incomplete abortion is the most common complication after miscarriage or abortion, which can lead to bleeding, infections, shock, and death if left untreated. Medication for incomplete abortion is less invasive and more acceptable than standard surgical treatment. This study aimed to compare the efficacy of different doses of femoston with expectant management for patients with incomplete abortions. Methods Patients diagnosed with incomplete abortion by transvaginal ultrasonography were included if they chose continued medical treatment rather than surgical intervention after relevant contraindications were excluded. Participants were divided into three groups: femoston(1/10) and femoston(2/10) group received different doses of femoston, and patients in control group received expectant treatment. Clinical characteristics of the participants, including age, gravidity, the diameter of the residual uterine content, the level of β-HCG in pre- and post-treatment, and whether missed abortion or scarred uterus were obtained. The success rate of complete abortion and the rate of menstrual recovery between the three groups were compared to evaluate the efficacy of different doses of femoston for patients with incomplete abortions. Results 197 patients were analyzed, 73 in the femoston (1/10) group, 73 in the femoston (2/10) group, and 51 patients were follow-up without treatment in the control group. The Femoston group was more effective than the control group with statistically significant (P < 0.001). And the success rate of complete abortion in the femoston (2/10) group was significantly higher than that of the femoston (1/10) group(P = 0.035). In addition, the rate of menstrual recovery in the femoston group was significantly higher than that in the control group (P = 0.007), and the rate in the femoston (2/10) group was also higher than the femoston (1/10) group with statistically significant (P = 0.001). Conclusions Femoston is effective in treating incomplete abortion, with femoston containing 2 mg of estrogen being more effective. For patients with incomplete abortion are treated with femoston, and menstrual recovery time may be shortened. Femoston may be a new option for the pharmacological treatment of incomplete abortion.

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Section: Discussionsupporting

confidence: 90%

Evaluation of different doses of Femoston therapy for incomplete abortion: A prospective observational trial

Huang

Gong

Cai

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Several studies have shown that the success rate of medication abortion correlates with the level of plasma HCG. [34,35] A similar phenomenon was observed in this study: the HCG level of patients in the control group after treatment was significantly higher than that in the femoston group, which was consistent with the higher failure rate in the control group. However, many factors can affect HCG levels, so the width of the residual, HCG levels, and symptoms should be combined in clinical practice in order to choose an appropriate treatment plan.…”

Section: Characteristicssupporting

confidence: 88%

Evaluation of different doses of Femoston therapy for incomplete abortion: A prospective observational trial

Wang,

Gong,

Cai

et al. 2023

Medicine

View full text Add to dashboard Cite

This study aimed to compare the efficacy of different doses of femoston with expectant management in patients with incomplete abortions. Patients diagnosed with incomplete abortion were included if they chose to continue medical treatment after relevant contraindications were excluded. Participants were divided into 3 groups: the femoston (1/10) and femoston (2/10) groups received different doses of femoston, and patients in the control group received expectant treatment. The success rate of complete abortion and the rate of menstrual recovery among the 3 groups were compared to evaluate the efficacy of different doses of femoston in patients with incomplete abortions. A total of 197 patients were analyzed: 73 in the femoston (1/10) group, 73 in the femoston (2/10) group, and 51 patients were followed up without treatment in the control group. The femoston group was significantly more effective than the control group P < .0001). The adjusted odds ratio (OR) and 95% confidence interval (CI) were 3.103 and 1.153 to 8.350 (P = .025). The success rate of complete abortion in the femoston (2/10) group was significantly higher than that in the femoston (1/10) group (adjusted OR: 0.403, 95% CI: 0.145–1.118, P = .081). In addition, the rate of menstrual recovery in the femoston group was significantly higher than that in the control group (P = .007), and the rate in the femoston (2/10) group was also higher than the femoston (1/10) group with statistically significant (P = .001). Femoston is effective in treating incomplete abortion, with femostons containing 2 mg estrogen being more effective. Patients with incomplete abortion are treated with femoston, and menstrual recovery time may be shortened. Femostons may be a new option for pharmacological treatment of incomplete abortions.

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Évaluation du succès de l’interruption volontaire de grossesse médicamenteuse par un seuil d’hCG sérique

Cited by 2 publications

References 26 publications

Evaluation of different doses of Femoston therapy for incomplete abortion: A prospective observational trial

Evaluation of different doses of Femoston therapy for incomplete abortion: A prospective observational trial

Evaluation of different doses of Femoston therapy for incomplete abortion: A prospective observational trial

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