Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency

Demir, Bülent; Demir, Sureyya Saridas; Karacaer, Kübra Özkan; Paşa, Semir; Sılan, Fatma

doi:10.4274/tjod.galenos.2019.09476

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Hemogram parameters, on the other hand, provide information regarding human health. Several studies showed the importance of hemogram parameters as predictors or indicators of dementia [ 5 ], primary ovarian insufficiency [ 6 ] and type 2 diabetes mellitus [ 3 ]. However, few studies have investigated the association between heavy metal pollution and hemogram parameters.…”

Section: Introductionmentioning

confidence: 99%

Gender Difference in the Associations among Heavy Metals with Red Blood Cell Hemogram

Huang

Wang

Chen

et al. 2021

IJERPH

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This study aimed to investigate gender differences in the association between heavy metals and hemograms including hemoglobin (Hgb), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC). A health survey of 2447 participants was conducted in southern Taiwan between June 2016 and September 2018. Seven heavy metals were measured: blood lead (Pb), urine nickel (Ni), urine chromium (Cr), urine manganese, urine arsenic (As), urine copper and urine cadmium (Cd). The results show that in females, Pb and Ni were significantly negatively associated with Hgb. In addition, As and Cd were significantly positively, and Pb and Ni were significantly negatively, associated with MCV, in males and females, respectively. The interactions between gender and Ni and gender and Cd in MCV were statistically significant. Further, Pb, in males, and Pb, Ni and Cr, in females, were significantly negatively associated with MCHC. In conclusion, in females, associations of red blood cell (RBC) hemograms with heavy metals such as Pb and Ni were found. In males, heavy metals such as Pb, As and Cd were found to associate with RBC hemograms. Further research is warranted to discuss the mechanism behind these associations.

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Section: Introductionmentioning

confidence: 99%

Gender Difference in the Associations among Heavy Metals with Red Blood Cell Hemogram

Huang

Wang

Chen

et al. 2021

IJERPH

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“…31).Ovarian aging causes a decline in estrogen production and an increase in inflammatory mediators. Thus, the ovarian reserve is diminished, and the number of inflammatory cells increases.…”

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confidence: 99%

May the Systemic Immune-Inflammation Index be an Indicator of Premature Ovarian Insufficiency?

Erin

2023

Middle Black Sea Journal of Health Science

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Aim: This study aimed to determine whether there was a correlation between the systemic immune-inflammation index and ovarian reserve markers such as follicle stimulant hormone, estradiol, and anti-müllerian hormone. Methods: The study comprised 65 people with premature ovarian insufficiency and 71 controls with similar demographics. The concentrations of hemoglobin, hematocrit, platelets, white blood cells, neutrophils, and lymphocytes were evaluated. The neutrophil leukocyte ratio, platelet lymphocyte ratio, and systemic immune-inflammation index were calculated. The antral follicle count reserves of all patients were evaluated by transvaginal ultrasonography. An independent t-test was used for the comparison of the study and control groups. Correlations between variables were analyzed using Pearson's correlation test. A p value of 0.05 was considered significant. Results: The results of the neutrophil-to-lymphocyte ratio and the platelet-lymphocyte ratio showed a significant difference between the groups (p = 0.043). The Systemic Immune Inflammation Index value was the statistically significant difference found between the groups. There was a significant positive correlation between the systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-lymphocyte ratio, and follicle stimulant hormone, while a significant negative correlation was found between the systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-lymphocyte ratio, antral follicle count, and anti-mullerian hormone. Conclusions: Our study was the first in this field to reveal the relationship between premature ovarian failure and the systemic immune-inflammation index. According to our study results, the systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-lymphocyte ratio are significantly higher in individuals with ovarian failure. It can be used as a marker for the diagnosis of premature ovarian insufficiency.

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Comparing the coagulation and platelet parameters of women with premature ovarian insufficiency with those of age‐matched controls: A case–control study

Lou,

Huang,

et al. 2024

Intl J Gynecology & Obste

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ObjectiveThis study aimed to compare the coagulation and platelet parameters in women with spontaneous premature ovarian insufficiency (POI) with those in age‐matched controls.MethodsThis case–control study recruited 202 women with POI and 202 age‐matched women with benign gynecological diseases as controls. Coagulation parameters, including prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), and thrombin time (TT), fibrinogen, and platelet parameters, including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW), were compared between women with POI and controls. Factors associated with coagulation and platelet parameters were also analyzed in women with POI.ResultsIn women with POI, higher fibrinogen levels and PDW, lower PLT, MPV, and PCT levels, and shorter TT were observed (p < 0.001). Linear regression analysis further revealed that women with POI were more likely to exhibit increased serum fibrinogen levels (β = 0.465, 95% confidence interval [CI] 0.366–0.564) and PDW (β = 0.340, 95% CI 0.300–0.379), decreased TT (β = −1.101, 95% CI –1.233–−0.969), PLT (β = −50.985, 95% CI –65.087–−36.882), MPV (β = −1.498, 95% CI –1.875 to −1.120), PCT levels (β = −0.084, 95% CI –0.095–−0.973). Additionally, follicle‐stimulating hormone levels were positively associated with fibrinogen levels in women with POI. There were no statistically significant differences in PT, INR, and APTT between women with POI and controls.ConclusionsWomen with POI exhibited decreased platelet numbers, abnormal platelet morphology, and elevated fibrinogen concentrations, potentially implicating POI's etiopathogenesis or contributing to an increased risk of cardiovascular disease in women with POI. No coagulation abnormalities were observed in women with POI.

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Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency

Cited by 4 publications

References 44 publications

Gender Difference in the Associations among Heavy Metals with Red Blood Cell Hemogram

Gender Difference in the Associations among Heavy Metals with Red Blood Cell Hemogram

May the Systemic Immune-Inflammation Index be an Indicator of Premature Ovarian Insufficiency?

Comparing the coagulation and platelet parameters of women with premature ovarian insufficiency with those of age‐matched controls: A case–control study

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