In recent years, there has been quite a dispute over the water shutoff effect of fuzzy ball fluids in fractured tight sandstone gas reservoirs. The core issue of this dispute is to try and make fuzzy ball fluid stabilize gas during the water shutoff process for sustainable development. In order to solve this dispute, the Linxing He-2 reservoir matrix core and a core with artificial fractures were used to simulate interlayer water, artificial fractures, and water output channels from the side and bottom. Simulated formation water and nitrogen were used as the two-phase flow phase. The breakthrough pressure of the air and water phases was tested after plugging with fuzzy ball fluid in order to simulate and analyze the water shutoff effect of the fuzzy ball fluid and its ability to achieve air establishment and water control. The results of this study show that for the core matrix, the breakthrough pressure gradient for water and gas varied from 0.200 MPa/cm to 0.210 MPa/cm and 0.015 MPa/cm to 0.025 MPa/cm, and for artificial fractured cores, the breakthrough pressure gradient of water and gas varied from 0.035 MPa/cm to 0.040 MPa/cm and 0.015 MPa/cm to 0.020 MPa/cm. These results prove that fuzzy ball fluid can block small-scale water output channels, such as matrix pores, through the polymer film-forming structure, and plug the artistic cracks and large-scale water output channels of the water flowing into the sides and bottom through the accumulation of a large number of fuzzy balls, which greatly improves the flow resistance of water. The amount of fuzzy ball fluid should be carefully adjusted with consideration of the water output and formation conditions. For large-scale water output channels and side and bottom water shutoff operations, it is recommended that the amount of fuzzy balls be increased along with the number of fuzzy balls in the system in order to increase the breakthrough pressure of water and achieve the stable control of air and water. It is believed that the fuzzy balls would quickly change their shapes to match the sizes of fracture channels to enter into fractured reservoirs and that an active hydrophobic membrane would form on the surface of fractured rocks, with macromolecules and surfactants being dispersed in the fluid system. In addition, the interface between the fuzzy balls is also hydrophobic, which would slow down the flow of water and provide a continuous gas percolating channel after aggregating and entering into the fractures. This increases the persistence of water intruding into the formation and does not affect the percolation of the gas of fractured tight sandstone gas reservoirs. This research is of great significance for the EOR of tight sand gas reservoirs and the sustainable development of oil and gas resources in China.