Evaluation methods and influencing factors of cough sensitivity

Mei, Hao; Gu, Wenhua; Ran, Linxin; Wen, Siwan; Yu, Li; Xu, Xianghuai

doi:10.1177/17534666211070134

Cited by 7 publications

(5 citation statements)

References 91 publications

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“…In preclinical animal studies, the invasive intratracheal mechanical stimulation was found to induce the cough reflex in anaesthetised rabbits/cats/dogs (16)(17)(18)(19)(20). For humans in clinical practice, the common area where the mechanical stimulation has been applied are the large airways level and the chest (8,9). In 2004, Lee and Eccles reported the first study to elicit cough in humans by the vibration of the airway at the trachea level with a modified men's shaver.…”

Section: Mechanical Challenge Testsmentioning

confidence: 99%

“…Cough sensitivity refers to the response of cough reflex to external noxious stimuli, including mechanical, chemical, and thermal stimuli ( 9 ). Patients with chronic cough (CC) often present with allotussia to innocuous stimuli, abnormal sensations or irritability in the throat (laryngeal paresthesia), and increased response to tussive stimuli (hypertussia).…”

Section: Cough Reflex Sensitivity Assessmentsmentioning

confidence: 99%

“…The standardized methodologies of cough challenge tests have been described elsewhere ( 6 , 9 , 39 ). The first administered concentrations of tussive stimuli causing two (C2) and five (C5) coughs are commonly taken as the endpoints of patients being told “cough if you need to”.…”

Section: Cough Reflex Sensitivity Assessmentsmentioning

confidence: 99%

See 2 more Smart Citations

Chronic cough—the limitation and advances in assessment techniques

Zhang¹,

Sykes²,

Brindle³

et al. 2022

J Thorac Dis

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Accurate and consistent assessments of cough are essential to advance the understanding of the mechanisms of cough and individualised the management of patients. Considerable progress has been made in this work. Here we reviewed the currently available tools for subjectively and objectively measuring both cough sensitivity and severity. We also provided some opinions on the new techniques and future directions.The simple and practical Visual Analogue Scale (VAS), the Leicester Cough Questionnaire (LCQ), and the Cough Specific Quality of Life Questionnaire (CQLQ) are the most widely used self-reported questionnaires for evaluating and quantifying cough severity. The Hull Airway Reflux Questionnaire (HARQ) is a tool to elucidate the constellation of symptoms underlying the diagnosis of chronic cough. Chemical excitation tests are widely used to explore the pathophysiological mechanisms of the cough reflex, such as capsaicin, citric acid and adenosine triphosphate (ATP) challenge test. Cough frequency is an ideal primary endpoint for clinical research, but the application of cough counters has been limited in clinical practice by the high cost and reliance on aural validation. The ongoing development of cough detection technology for smartphone apps and wearable devices will hopefully simplify cough counting, thus transitioning it from niche research to a widely available clinical application.

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Section: Mechanical Challenge Testsmentioning

confidence: 99%

Section: Cough Reflex Sensitivity Assessmentsmentioning

confidence: 99%

See 1 more Smart Citation

Chronic cough—the limitation and advances in assessment techniques

Zhang¹,

Sykes²,

Brindle³

et al. 2022

J Thorac Dis

View full text Add to dashboard Cite

show abstract

“…However, the collection of signs and symptoms using questionnaires is subjective since it is biased by patient perception [12]. Available objective methods for assessing cough have been limited to cough sensitivity assessments, which require chemical or mechanical stimulation [13].…”

Section: Introductionmentioning

confidence: 99%

Cough Detection Using Acceleration Signals and Deep Learning Techniques

Sanchez-Morillo,

Sales-Lerida,

Priego-Torres

et al. 2024

Electronics

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Cough is a frequent symptom in many common respiratory diseases and is considered a predictor of early exacerbation or even disease progression. Continuous cough monitoring offers valuable insights into treatment effectiveness, aiding healthcare providers in timely intervention to prevent exacerbations and hospitalizations. Objective cough monitoring methods have emerged as superior alternatives to subjective methods like questionnaires. In recent years, cough has been monitored using wearable devices equipped with microphones. However, the discrimination of cough sounds from background noise has been shown a particular challenge. This study aimed to demonstrate the effectiveness of single-axis acceleration signals combined with state-of-the-art deep learning (DL) algorithms to distinguish intentional coughing from sounds like speech, laugh, or throat noises. Various DL methods (recurrent, convolutional, and deep convolutional neural networks) combined with one- and two-dimensional time and time–frequency representations, such as the signal envelope, kurtogram, wavelet scalogram, mel, Bark, and the equivalent rectangular bandwidth spectrum (ERB) spectrograms, were employed to identify the most effective approach. The optimal strategy, which involved the SqueezeNet model in conjunction with wavelet scalograms, yielded an accuracy and precision of 92.21% and 95.59%, respectively. The proposed method demonstrated its potential for cough monitoring. Future research will focus on validating the system in spontaneous coughing of subjects with respiratory diseases under natural ambulatory conditions.

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“… 3 , 4 Cough sensitivity, the sensitivity of cough reflex arc, is defined as the responsiveness of cough reflex to external stimuli. 5 , 6 At present, there are many subjective and objective tests or tools to assess cough sensitivity, among which the cough challenge test is widely used. 7 Drawing on the cough challenge test, researchers have recently proposed the cough suppression test to demonstrate that the cough suppression ability of patients with chronic cough is weaker than the normal population.…”

mentioning

confidence: 99%

Similarities and differences between the cough suppression test and the cough challenge test

Zhao

Bai

Wen

et al. 2023

Ther Adv Respir Dis

Self Cite

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In recent years, a new test method namely the cough suppression test has been proposed to measure cough suppression in patients with chronic cough. The cough suppression test is a modified test based on capsaicin tussive challenge. There are similarities and differences between it and the more established cough challenge test in detection method, purpose and clinical significance. In this article, we will introduce and compare the concepts, application and methodology of the cough suppression test and the cough challenge test, summarize this research progress and problems of the two methods, and predict the possible role of both in the further study of chronic cough.

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Evaluation methods and influencing factors of cough sensitivity

Cited by 7 publications

References 91 publications

Chronic cough—the limitation and advances in assessment techniques

Chronic cough—the limitation and advances in assessment techniques

Cough Detection Using Acceleration Signals and Deep Learning Techniques

Similarities and differences between the cough suppression test and the cough challenge test

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