Evaluation of 170 Followed-up Cases Treated for Hydatid Disease: A Multicentre Study

Işık, Sinem Akkaya; Seyman, Derya; Zerdali, Esra; Ayan, Saliha; Kakalicoglu, Deniz; Ayaz, Tunahan; Ünlü, Esra Canbolat; Çeti̇nkaya, Rıza Aytaç; Yeni̇lmez, Ercan; Görenek, Levent; Köse, Şükran

doi:10.4274/tpd.galenos.2020.6737

Cited by 7 publications

(6 citation statements)

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“…Liver lesions cause a decrease in the number of hepatocytes and conclude the uridine diphosphate glucuronic transferase (UDPGT) enzyme, which is involved in conjugation, is not to be produced in sufficient amounts. Therefore, the amount of UCB increases (Işik et al, 2020;Kinci et al, 2021). In our study, direct and total bilirubin levels were evaluated, and it was revealed that total bilirubin levels increased significantly in the LTZ group.…”

Section: Discussionmentioning

confidence: 80%

The effect of letrozole on liver function and some biochemical parameters in rats

Dolanbay,

Makav,

Vural

et al. 2024

Journal of Advances in VetBio Science and Techniques

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Letrozole (LTZ), is an aromatase inhibitor, that has been widely used in a variety of diseases such as polycystic ovary syndrome, endometriosis, and breast cancer. LTZ is received via the oral route and metabolized in the liver. Therefore, LTZ may have toxic effects like other drugs metabolized in the liver. Based on this, our study aimed to investigate the effect of LTZ on liver function and biochemical parameters. For this purpose, 16 Wistar albino female rats were divided into two groups (n=8): Control and LTZ respectively. The rats in the letrozole group were administered with 2 mL/kg LTZ by oral gavage once a day for 21 days. The Control group received the vehicle once a day for 21 days. Blood samples were collected on the 22nd day of the experiment. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), albumin (ALB), alkaline phosphatase (ALP), direct bilirubin and total bilirubin were measured. Biochemical analysis indicated that ALT, AST, LDH, ALP, and total bilirubin levels were significantly higher in the LTZ administrated group compared to the Control. ALB levels decreased in the LTZ group. In conclusion, it was determined that LTZ has toxic and detrimental effects on the liver. We suggested that long-term LTZ administrated patients should be under control against liver damage and may have liver supporting adjuvant therapies for robust liver functions.

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Section: Discussionmentioning

confidence: 80%

The effect of letrozole on liver function and some biochemical parameters in rats

Dolanbay,

Makav,

Vural

et al. 2024

Journal of Advances in VetBio Science and Techniques

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“…However, it is thought that this increase is not a real increase and is related to the 2015 year-end regulation of the surveillance of infectious diseases mandatory to be notified by the Ministry of Health (1). Although it has been shown that HD can be observed at any age, it has been reported that the disease usually becomes symptomatic years after contact in childhood (6). In the HERACLES study, it was found that the prevalence of HD increased gradually with age in Turkiye (11).…”

Section: Discussionmentioning

confidence: 96%

“…In patients with cyst leakage or rupture, eosinophilia may be observed in the hemogram or peripheral smear, unlike in patients with cyst membrane integrity (19). In the study by Akkaya Işık et al (6), the most common laboratory finding was anemia (25.3%) while eosinophilia was detected in 19%, AST in 15%, ALT in 19% and elevated T.bilirubin in 11%. In the study of Güreser et al (12), GGT (28%), ALT (16%), AST (16%), and ALP (13%) elevations and eosinophilia were found in 19%.…”

Section: Discussionmentioning

confidence: 96%

“…In the study of Öztürk-Durmaz et al(15), 52 (50.4%) of 103 patients underwent the IHA test, and positivity was established in 27 (51.9%). In the study of Akkaya Işık et al(6), IHA test positivity was 81.8%. In our study, the hydatid cyst IHA test was performed in 93.9% of the patients and 77.4% were positive and this rate is similar to the literature.…”

mentioning

confidence: 93%

“…In HD, cysts may remain in the affected organ for years without symptoms. Although symptoms related to the liver and lungs are more common, they may vary according to the affected organ (6). In addition to clinical symptoms and findings, radiologic tests including ultrasonography (USG), computed tomography (CT), direct radiography and magnetic resonance imaging (MRI), serologic tests, and direct diagnostic and molecular methods are utilized in the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Retrospective Evaluation of Adult Hydatid Cyst Cases

Çelik,

Baran,

Altındağ

et al. 2024

Genel Tıp Dergisi

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Aim: The aim of this study was to evaluate the characteristics of adult patients followed up for hydatid cysts disease. Method: Patients over the age of 18 years who were diagnosed with hydatid disease, between January 2015 and September 2021 were included in the study. The clinical, laboratory and radiologic characteristics of the patients were evaluated retrospectively. Results: The study included 66 patients. 59.1% of the patients were female and the mean age was 40.9±15.60 years. The most common presenting symptom was abdominal pain (42.4%). The most common sites of involvement were the liver (78.8%) and lung (18.2%). The majority of patients had solitary cysts (84.8%). The most common finding in laboratory tests was elevated total IgE (74.1%). The indirect hemagglutination (IHA) test was positive in 77.4% of the patients tested. Conclusion: In our study, it was concluded that hydatid cysts are most commonly seen in the liver, often with single organ involvement, and that elevated total IgE in laboratory diagnosis may be helpful in the diagnosis of hydatid cyst disease, although it does not make a definitive diagnosis.

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