Evaluation of 2-point, 3-point, and 6-point Dixon magnetic resonance imaging with flexible echo timing for muscle fat quantification

Grimm, Alexandra; Meyer, Heiko; Nickel, Dominik; Nittka, Mathias; Raithel, Esther; Chaudry, Oliver; Friedberger, Andreas; Uder, Michael; Kemmler, Wolfgang; Quick, Harald H.; Engelke, Klaus

doi:10.1016/j.ejrad.2018.04.011

Cited by 76 publications

(63 citation statements)

References 26 publications

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“…The Dixon sequence was a Gradient Echo Volumetric Interpolated Breathhold Examination 6pt Dixon prototype sequence (sequence parameter: image resolution: 0.8 × 0.8 × 3.0 mm 3 ; slices: 36, no spacing between slices; matrix size: 320 × 320; TR: 14.00 ms; TEs: 1.90, 3.73, 5.56, 7.39, 9.22, and 11.05 ms; bandwidth: 710 Hz/px; acquisition time: 1:17 min). Minimum possible TE values were selected at the given image resolution as validated previously . T 2 *‐decay was considered as a degree of freedom in the parameter extraction, and the effect on the extracted water and fat signals was eliminated using a multi‐step fitting approach .…”

Section: Methodsmentioning

confidence: 99%

“…Minimum possible TE values were selected at the given image resolution as validated previously. 25 T 2 *-decay was considered as a degree of freedom in the parameter extraction, and the effect on the extracted water and fat signals was eliminated using a multi-step fitting approach. 23 From the 6pt Dixon sequence, PDFF and PDWF maps were obtained.…”

Section: Magnetic Resonance Data Acquisition and Magnetic Resonance Ementioning

confidence: 99%

“…Dixon MRI is gaining importance in clinical practice as it matches the accuracy of spectroscopy but provides fat assessment with high spatial resolution. [18][19][20][21][22][23] In muscle, a high correlation between MRS and T 2 *-corrected 6pt Dixon MRI with calibrated spectral modelling of fat [23][24][25] has been shown for fat fraction measurements; however, to our knowledge in muscle, the repeatability of MRS and Dixon imaging PDFF measurements has not been investigated so far.…”

Section: Introductionmentioning

confidence: 99%

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Repeatability of Dixon magnetic resonance imaging and magnetic resonance spectroscopy for quantitative muscle fat assessments in the thigh

Grimm

Meyer

Nickel

et al. 2018

J cachexia sarcopenia muscle

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BackgroundChanges in muscle fat composition as for example observed in sarcopenia or muscular dystrophy affect physical performance and muscular function, like strength and power. The purpose of the present study is to measure the repeatability of Dixon magnetic resonance imaging (MRI) for assessing muscle volume and fat in the thigh. Furthermore, repeatability of magnetic resonance spectroscopy (MRS) for assessing muscle fat is determined.MethodsA prototype 6‐point Dixon MRI method was used to measure muscle volume and muscle proton density fat fraction (PDFF) in the left thigh. PDFF was measured in musculus semitendinosus of the left thigh with a T2‐corrected multi‐echo MRS method. For the determination of short‐term repeatability (consecutive examinations), the root mean square coefficients of variation of Dixon MRI and MRS data of 23 young and healthy (29 ± 5 years) and 24 elderly men with sarcopenia (78 ± 5 years) were calculated. For the estimation of the long‐term repeatability (13 weeks between examinations), the root mean square coefficients of variation of MRI data of seven young and healthy (31 ± 7 years) and 23 elderly sarcopenic men (76 ± 5 years) were calculated. Long‐term repeatability of MRS was not determined.ResultsShort‐term errors of Dixon MRI volume measurement were between 1.2% and 1.5%, between 2.1% and 1.6% for Dixon MRI PDFF measurement, and between 9.0% and 15.3% for MRS. Because of the high short‐term repeatability errors of MRS, long‐term errors were not determined. Long‐term errors of MRI volume measurement were between 1.9% and 4.0% and of Dixon MRI PDFF measurement between 2.1% and 4.2%.ConclusionsThe high degree of repeatability of volume and PDFF Dixon MRI supports its use to predict future mobility impairment and measures the success of therapeutic interventions, for example, in sarcopenia in aging populations and muscular dystrophy. Because of possible inhomogeneity of fat infiltration in muscle tissue, the application of MRS for PDFF measurements in muscle is more problematic because this may result in high repeatability errors. In addition, the tissue composition within the MRS voxel may not be representative for the whole muscle.

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Section: Methodsmentioning

confidence: 99%

Section: Magnetic Resonance Data Acquisition and Magnetic Resonance Ementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Repeatability of Dixon magnetic resonance imaging and magnetic resonance spectroscopy for quantitative muscle fat assessments in the thigh

Grimm

Meyer

Nickel

et al. 2018

J cachexia sarcopenia muscle

Self Cite

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show abstract

“…A 2‐point Dixon sequence acquires 2 different images, 1 with fat and water in phase and the other with fat and water in opposing phases. A 3‐point Dixon sequence acquires a third set of images that is typically used to correct for inhomogeneities in the magnetic field . The addition or subtraction of the resultant in‐phase or opposed‐phase images can be used to produce fat and water images, in which the intensity of individual pixels is proportional to fat or water concentration in that pixel (Fig.…”

Section: Evaluating Intramuscular Fatmentioning

confidence: 99%

Advancements in magnetic resonance imaging‐based biomarkers for muscular dystrophy

Leung

2019

Muscle and Nerve

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Recent years have seen steady progress in the identification of genetic muscle diseases as well as efforts to develop treatment for these diseases. Consequently, sensitive and objective new methods are required to identify and monitor muscle pathology. Magnetic resonance imaging offers multiple potential biomarkers of disease severity in the muscular dystrophies. This Review uses a pathology‐based approach to examine the ways in which MRI and spectroscopy have been used to study muscular dystrophies. Methods that have been used to quantitate intramuscular fat, edema, fiber orientation, metabolism, fibrosis, and vascular perfusion are examined, and this Review describes how MRI can help diagnose these conditions and improve upon existing muscle biomarkers by detecting small increments of disease‐related change. Important challenges in the implementation of imaging biomarkers, such as standardization of protocols and validating imaging measurements with respect to clinical outcomes, are also described.

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“…In der Praxis führen globale und lokale Magnetfeldinhomogenitäten und ein T2*-Zerfall zu leichten Änderungen in den Werten der Resonanzfrequenzen, was durch die Akquisition weiterer Echos (sog. Mehrpunkt-Dixon-Sequenzen) kompensiert werden kann [47,48]. Mit 6 pt (6 Punkt) Dixon-Sequenzen kann am Oberschenkel routinemäßig eine Pixelgröße von 0,7 mm 2 bei einer Schichtdicke von 3 mm erreicht werden.…”

Section: D-bildgebung Mit Mrtunclassified

Quantitative MR-Bildgebung zur Charakterisierung der Skelettmuskulatur

2020

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ZusammenfassungDieser Beitrag gibt einen Überblick über Magnetresonanztomographie-basierte (MRT-basierte) Methoden zur Quantifizierung der Muskeldegeneration. Neben Muskelvolumen kann mit Dixon-Bildgebung insbesondere der prozentuale Fettgehalt bestimmt werden. Daneben gibt es Ansätze, frühe Anzeichen einer Degeneration über die Verteilung des Entzündungsgrades oder der Natriumkonzentration in der Muskulatur zu visualisieren und quantifizieren. Bis auf die Natrium-Bildgebung werden diese Methoden bei Muskelerkrankungen routinemäßig zur Diagnose und Verlaufskontrolle eingesetzt.Im Bereich der Osteologie und Gerontologie wird zwar die Bedeutung der Muskel-Knochen-Einheit unter anderem für Frakturprädiktion und Gebrechlichkeit im Alter immer wieder betont, Degeneration der Muskulatur wird aber im Wesentlichen über extrinsische Parameter wie Muskelkraft und -funktion erfasst. Häufig benutzte intrinsische Parameter wie DXA Lean Mass oder Muskelvolumen, bestimmt mit CT oder MRT, korrelieren nur mäßig mit extrinsischen Parametern. Eine genauere Charakterisierung von Muskelqualität sollte dieses Manko aber beseitigen. Mit CT und MRT stehen entsprechende Methoden zur Verfügung, die jetzt aber in Studien zur altersassoziierten Muskeldegeneration, in Interventionsstudien und in Studien zur Frakturrisikoprognostik auch eingesetzt werden müssen.

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Evaluation of 2-point, 3-point, and 6-point Dixon magnetic resonance imaging with flexible echo timing for muscle fat quantification

Cited by 76 publications

References 26 publications

Repeatability of Dixon magnetic resonance imaging and magnetic resonance spectroscopy for quantitative muscle fat assessments in the thigh

Repeatability of Dixon magnetic resonance imaging and magnetic resonance spectroscopy for quantitative muscle fat assessments in the thigh

Advancements in magnetic resonance imaging‐based biomarkers for muscular dystrophy

Quantitative MR-Bildgebung zur Charakterisierung der Skelettmuskulatur

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