Evaluation of 216 four-year survivors of acute leukemia

Jacquillat, C; Wkil, M.; Gemon, M F; Izrael, V.; Schaison, G; Auclerc, G.; Ablin, Arthur R.; Flandrin, Georges; Tanzer, J; Bussel, A; C, Weisgerber; Dresch, C; Najean, Y; Goudemand, M; Séligmann, M; Boiron, M; Bernard, J

doi:10.1002/1097-0142(197308)32:2<286::aid-cncr2820320202>3.0.co;2-v

Cited by 41 publications

(4 citation statements)

References 8 publications

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“…1.3.9.1 1.36. 37 All four patients were induced into remission and maintained on standard therapeutic approaches. One patient (Case 1) received cyclophosphamide maintenance for only two months and no CNS prophylaxis prior to relapse according to therapy in use at that time.…”

Section: Resultsmentioning

confidence: 99%

Pelvic and ovarian extramedullary leukemic relapse in young girls. A report of four cases and review of the literature

Cecalupo

Frankel

Sullivan

1982

Cancer

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Currently attention is focused on the testicle as a site of leukemic relapse. Leukemic involvement of the ovary has been described in several autopsy series with an incidence of 11–50% in patients with bone marrow relapse, but has rarely been reported during the clinical course of leukemia. In this report, four girls with childhood acute lymphocytic leukemia (ALL) who relapsed with a pelvic mass are presented. Three had marked ovarian infiltrates and the fourth had a presacral mass without ovarian disease. Involvement was also present in abdominal and pelvic lymph nodes, mesentery, omentum, and serosal surfaces. Two patients had infiltrates of the fallopian tubes and one had uterine involvement. Two patients had central nervous system disease and one patient had renal involvement at the time of relapse. Relapse occurred late in the course of disease. All patients had been in complete continuous remission prior to relapse. Retreatment was instituted in all patients and follow‐up ranges from 18–135 months from the time of pelvic relapse. All patients have maintained continuous bone marrow remission from the time of initial diagnosis, and one patient died 18 months after ovarian relapse with significant extramedullary disease but no marrow involvement. This represents the first series of pelvic extramedullary leukemic relapse in females, an area of involvement that may be encountered more frequently in the future.

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Section: Resultsmentioning

confidence: 99%

Pelvic and ovarian extramedullary leukemic relapse in young girls. A report of four cases and review of the literature

Cecalupo

Frankel

Sullivan

1982

Cancer

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“…Jacquillat and co-workers analyzed a series of long-term survivors with ALL in whom prolonged second remissions were obtained, and concluded that these patients were initially undertreated. 7 Leventhal and co-work-er@ reported on five patients who were in long-term second remissions following relapses after an unmaintained remission of at least 6 months. These patients had received an initial treatment that was not continued beyond 15 months.…”

Section: Discussionmentioning

confidence: 99%

Recurrent childhood lymphocytic leukemia following cessation of therapy.Treatment and response

Rivera¹,

Pratt²,

Aur³

et al. 1976

Cancer

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A unique population of patients--children who developed recurrent acute lymphocytic leukemia (ALL) following cessation of initial prolonged therapy--was studied. During a 2-year period, 17 such children were admitted to a planned combination chemotherapy program. Complete bone-marrow remissions were achieved in 16 patients, and the median duration of second hematologic remissions was 216 days. These responses were significantly better than those obtained in seven patients who relapsed during the administration of continuation chemotherapy. Although the rate and duration of induced remissions were notably high, 9 of the 17 patients who relapsed off therapy have again developed recurrent leukemia. This result, together with the moderate toxicity encountered during treatment, indicates that more therapy is needed. The equal proportion of bone marrow and meningeal relapses was interpreted to mean that a secon course of preventive central nervous system therapy early in remission may be especially useful.

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“…Favorable prognostic factors for long-term survival after standard chemotherapy are associated with the subgroup of acute promyelocytic leukemia (APL), characterized by translocation t (15,17), which yields a significantly longer disease-free survival than does the AML group as whole (6,88). Other factors correlated with the length of disease-free survival in AML are rapid achievement of CR as a result of induction treatment (6,88,89) and (probably) the presence of two other chromosomal abnormalities: inversion of chromosome 16 and t(8;21) (90,91). Factors negatively influencing remission duration are a history of a preexisting hematological disorder and presence of chromosomal abnormalities such as t(9;22) or monosomy 5 or 7 (80,90,91).…”

Section: Who Can Be Cured By Chemotherapy Alone?mentioning

confidence: 99%

Critical issues in autologous bone marrow transplantation in adult acute leukemia

Beran

Zander

1987

European J of Haematology

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Evaluation of 216 four-year survivors of acute leukemia

Cited by 41 publications

References 8 publications

Pelvic and ovarian extramedullary leukemic relapse in young girls. A report of four cases and review of the literature

Pelvic and ovarian extramedullary leukemic relapse in young girls. A report of four cases and review of the literature

Recurrent childhood lymphocytic leukemia following cessation of therapy.Treatment and response

Critical issues in autologous bone marrow transplantation in adult acute leukemia

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