Evaluation of 4 different bone graft substitutes and autogenous bone grafting in root-end resection osteotomies after retrograde root-filling with Intermediate Restorative Material (IRM): An experimental study in dogs

Wälivaara, Dan-Åke; Abrahamsson, Peter

doi:10.4236/ojst.2013.32035

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…The histomorphometric analysis in the present study revealed that the bone volume value in the osseous defects filled with PTG was higher than those occupied with Nanobone® but no statistically significant difference could be detected between the two groups. This agreed with Wälivaara and Abrahamsson in 2013 (18) where no statistically significant difference could be detected between autogenous bone or one of the bone graft substitutes, when they were used to fill osseous defects in dogs following apicectomy of mandibular premolars. This non -significant difference might be explained by sample size limitation.…”

Section: Discussionsupporting

confidence: 88%

A Comparative Study Between Porous Titanium Granules and Nanocrystalline Hydroxyapatite in Healing of Mandibular Defects in Dogs

Ahmed

Mahmoud

Shafik

et al. 2015

Alexandria Dental Journal

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Background: Bone grafting is a common technique in Oral and Maxillofacial surgery to replace missing bone. Grafting materials include autografts, allografts, xenografts and synthetic bone substitutes. Two synthetic bone materials are currently available; porous titanium granules and nanocrystalline hydroxyapatite. Objectives: This study compared the use of Porous titanium granules (PTG) versus Nanobone® in healing of mandibular defects in dogs and this was estimated by histological and histomorphometric analysis. Materials and Methods: The study was conducted on 10 healthy experimental dogs. An osseous defect of 10mm depth and 10mm width was created in the premolar area of both right and left sides of the mandible. The right side defects were grafted with PTG while the left side defects were grafted with Nanobone®. Histological and histomorphometrical evaluation was carried out to monitor bone healing and quantify the bone volume with both PTG and Nanobone® at 3, 6 and 12 weeks intervals post-operatively. Results: The mean bone volume value with PTG was 773.4 ± 499.4 on the 3rd week, then increased on the 6th week to be 10125.3 ± 19287.3 and 2676.0 ± 1388.2 on the 12th week. The mean bone volume value with Nanobone® was 525.5 ± 332.1 on the 3rd week, then on the 6th week it became 287.4 ± 322.5. There was a statistically significant increase on the 12th to be 1976.8 ± 1568.1.. There was a statistically significant difference regarding the mean bone volume value between the two groups. Conclusion: Both PTG and Nanobone® have osteoconductive properties and are effective in healing bone defects, but the histomorphometric analysis quantified the bone volume with both PTG and Nanobone® and revealed that the maximum amount of the total regenerated bone was seen in the PTG group; bone was formed within its porosities

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Section: Discussionsupporting

confidence: 88%

A Comparative Study Between Porous Titanium Granules and Nanocrystalline Hydroxyapatite in Healing of Mandibular Defects in Dogs

Ahmed

Mahmoud

Shafik

et al. 2015

Alexandria Dental Journal

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“…Histological specimens were evaluated qualitatively and semi‐quantitatively on the basis of established scoring methods in bone histology and pathology or own published methods as well as methods from the literature on certain parameters investigated in similar studies on the healing of bone replacement materials . The assessment was always performed in a blinded way by two independent, histologically experienced examiners on three different sections of the section series (central, lateral).…”

Section: Methodsmentioning

confidence: 99%

Histological and immunohistochemical comparison of two different allogeneic bone grafting materials for alveolar ridge reconstruction: A prospective randomized trial in humans

Solakoglu

Götz

Heydecke

et al. 2019

Clin Implant Dent Rel Res

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BackgroundPreclinical studies have hypothesized a possible immunological reponse to allogeneic materials due to detection of remnants of potential immunogenic molecules. However, their impact on integration, bone remodeling and immunological reaction after the augmentation procedure is largely unknown and a direct correlation of analytical data and evaluation of human biopsies is missing.PurposeThe present study aimed to compare two commercially available allogeneic materials regarding their content of cellular remnants as well as the bone remodeling, and integration and potential immunologic reactions on a histological and immunohistochemical level, integrating also in vitro analytical evaluation of the specific batches that were used clinically.Materials and MethodsTwenty patients were randomly assigned to treatment with Maxgraft or Puros for lateral ridge augmentation in a two‐stage surgery. After a mean healing period of 5 months, implants were placed and biopsies were taken for histological, immunhistochemical, and histomorphometrical evaluation regarding bone remodeling and inflammation, protein concentrations in vitro and the presence of MHC molecules of the same batches used clinically.ResultsNo differences in clinical outcome, histological, immunohistochemical, and in vitro protein analysis between the two bone grafting materials were observed. Active bone remodeling, amount of newly formed bone, and residual grafting material was independent of the materials used, but varied between subjects. MHC1 residues were not detected in any sample.ConclusionsWithin the limitations of this study, both tested materials yielded equivalent results in terms of clinical outcome, new bone formation, and lack of immunological potential on a histological and immunohistochemical level.

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“…The intensity of osteogenesis was assessed semi-qualitatively using the following scoring system: 0 = no features of osteogenesis; 1 = bone formation around graft (e.g., granules) with the appearance of osteoblasts and deposition of osteoid; 2 = bone formation around graft with primary bone features; 3 = bone trabeculae formation around grafts with features of active remodeling (detection of lamellar bone with primary osteons and osteocytes, vascular detection, fibrous bone remnants in the lamellar bone, and remains of bone replacement nanomaterial embedded in/on the bone); 4 = mature lamellar bone with osteons [14]. In addition, the immune reaction to NG was assessed using a semi-quantitative score according to the following scheme: 0 = none; 1 = loose infiltrates, disseminated or focal; 2 = dense, moderately extensive lymphocytic infiltrates; 3 = extensive, dense lymphocytic infiltrates with edema and focal giant cells; 4 = pronounced inflammatory reaction including giant cells and necrosis [27]. The assessment was performed by two independent observers blindly…”

Section: Histological Evaluation Of Bone Augmentation With Ha/β-tcpmentioning

confidence: 99%

From Synthesis to Clinical Trial: Novel Bioinductive Calcium Deficient HA/β-TCP Bone Grafting Nanomaterial

Mishchenko,

Yanovska,

Sulaieva

et al. 2023

Nanomaterials

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Maxillary sinus augmentation is a commonly used procedure for the placement of dental implants. However, the use of natural and synthetic materials in this procedure has resulted in postoperative complications ranging from 12% to 38%. To address this issue, we developed a novel calcium deficient HA/β-TCP bone grafting nanomaterial using a two-step synthesis method with appropriate structural and chemical parameters for sinus lifting applications. We demonstrated that our nanomaterial exhibits high biocompatibility, enhances cell proliferation, and stimulates collagen expression. Furthermore, the degradation of β-TCP in our nanomaterial promotes blood clot formation, which supports cell aggregation and new bone growth. In a clinical trial involving eight cases, we observed the formation of compact bone tissue 8 months after the operation, allowing for the successful installation of dental implants without any early postoperative complications. Our results suggest that our novel bone grafting nanomaterial has the potential to improve the success rate of maxillary sinus augmentation procedures.

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Evaluation of 4 different bone graft substitutes and autogenous bone grafting in root-end resection osteotomies after retrograde root-filling with Intermediate Restorative Material (IRM): An experimental study in dogs

Abstract: ABSTRACT

Cited by 4 publications

References 22 publications

A Comparative Study Between Porous Titanium Granules and Nanocrystalline Hydroxyapatite in Healing of Mandibular Defects in Dogs

A Comparative Study Between Porous Titanium Granules and Nanocrystalline Hydroxyapatite in Healing of Mandibular Defects in Dogs

Histological and immunohistochemical comparison of two different allogeneic bone grafting materials for alveolar ridge reconstruction: A prospective randomized trial in humans

From Synthesis to Clinical Trial: Novel Bioinductive Calcium Deficient HA/β-TCP Bone Grafting Nanomaterial

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