Evaluation of 50-kHz ultrasonic vocalizations in animal models of mania: Ketamine and lisdexamfetamine-induced hyperlocomotion in rats

Wendler, Etiéli Mara; Souza, Camila Pasquini de; Vecchia, Débora Dalla; Kanazawa, Luiz Kae Sales; Hocayen, Palloma de Almeida Soares; Wöhr, Markus; Schwarting, Rainer K.W.; Andreatini, Roberto

doi:10.1016/j.euroneuro.2016.10.012

Cited by 25 publications

(30 citation statements)

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“…When modeling mania-like elevated drive, i.e., exposing rats to amphetamine, CONT and APA rats displayed an increase in locomotor activity of similar strength in our study. Moreover, the emission of amphetamine-induced 50-kHz USV, possibly reflecting mania-like elevated mood [49,50], did not differ between our CONT and APA rats. Increases were of similar strength in both experimental groups, indicating that APA effects on 50-kHz USV production specifically occur in a social context, rough-and-tumble play, but not in a non-social one, namely amphetamine treatment.…”

Section: Behavioral Phenotypes In Ratsmentioning

confidence: 50%

“…2f). Moreover, the emission of amphetamine-induced 50-kHz USV, possibly reflecting mania-like elevated mood [49,50], did not differ between CONT and APA rats. While 50-kHz USV emission during baseline and saline conditions was minimal and not different between groups (p = .775 and p = .826, respectively; Supplementary Fig.…”

Section: Animal Study Comprehensive Longitudinal Behavioral Phenotypingmentioning

confidence: 82%

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Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study

et al. 2020

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Advanced paternal age (APA) is a risk factor for several neurodevelopmental disorders, including autism and schizophrenia. The potential mechanisms conferring this risk are poorly understood. Here, we show that the personality traits schizotypy and neuroticism correlated with paternal age in healthy subjects (N = 677). Paternal age was further positively associated with gray matter volume (VBM, N = 342) in the right prefrontal and the right medial temporal cortex. The integrity of fiber tracts (DTI, N = 222) connecting these two areas correlated positively with paternal age. Genome-wide methylation analysis in humans showed differential methylation in APA individuals, linking APA to epigenetic mechanisms. A corresponding phenotype was obtained in our rat model. APA rats displayed social-communication deficits and emitted fewer pro-social ultrasonic vocalizations compared to controls. They further showed repetitive and stereotyped patterns of behavior, together with higher anxiety during early development. At the neurobiological level, microRNAs miR-132 and miR-134 were both differentially regulated in rats and humans depending on APA. This study demonstrates associations between APA and social behaviors across species. They might be driven by changes in the expression of microRNAs and/or epigenetic changes regulating neuronal plasticity, leading to brain morphological changes and fronto-hippocampal connectivity, a network which has been implicated in social interaction.

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Section: Behavioral Phenotypes In Ratsmentioning

confidence: 50%

Section: Animal Study Comprehensive Longitudinal Behavioral Phenotypingmentioning

confidence: 82%

Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study

et al. 2020

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“…It is also of relevance to note that differential sensitivity between two sexes to ketamine, in terms of locomotor sensitization (females being more sensitive than males), has been recently reported [ 29 ]. Moreover, although the high dose of ketamine is sedative, the low doses of ketamine used in our study do not appear to result in any sedation [ 18 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 94%

Ketamine Differentially Attenuates Alcohol Intake in Male Versus Female Alcohol Preferring (P) Rats

et al. 2017

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BackgroundAlthough various pharmacological tools in combating addiction to alcohol are available, their efficacy is limited. Hence, there is a critical need for development of more effective medications. Recent advances in the field have identified the glutamatergic system as a potential novel target for intervention in addictive behaviors.PurposeHence, we evaluated the effects of acute administration of low (subanesthetic) doses of ketamine, an NMDA receptor antagonist, on alcohol intake and alcohol preference in both male and female rats.Study designAdult alcohol preferring (P) rats were exposed to two-bottle choice (ethanol 10% and water) for at least three weeks following a nine-day training period and the effects of various doses of ketamine (5 mg/kg, 7.5 mg/kg, and 10 mg/kg, injected subcutaneously, SC) on consumption of alcohol over various time periods during a 24 h interval were measured.ResultsOur results indicate that ketamine treatment significantly reduced both alcohol intake and preference in a time- and dose-dependent manner in both sexes. Moreover, a differential sensitivity between the sexes was observed. Thus, although alcohol intake was higher in males, female rats responded much more strongly to the highest dose of ketamine than males in the initial time periods.ConclusionIt is concluded that glutamatergic receptor manipulations may be of therapeutic potential in addiction to alcohol and that different sexes may respond differentially to such treatments.

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“…Another parameter that can be analyzed in order to evaluate changes in behavior is alterations in the emission of USVs by the animal. Wendler et al (2016) used LDX administration as model of mania to induce increases in 50-kHz USVs in rats. Studies show that psychostimulants and SD induce increases in 50-kHz USVs in rats, which can be inhibited by drugs used in the management of BD, such as antipsychotics and lithium (Wendler et al, 2019;Wendler et al, 2016;Barker et al, 2015;Rippberger et al, 2015;.…”

Section: Lisdexamfetamine (Ldx)-induced Increases In 50-khz Usvsmentioning

confidence: 99%

“…Wendler et al (2016) used LDX administration as model of mania to induce increases in 50-kHz USVs in rats. Studies show that psychostimulants and SD induce increases in 50-kHz USVs in rats, which can be inhibited by drugs used in the management of BD, such as antipsychotics and lithium (Wendler et al, 2019;Wendler et al, 2016;Barker et al, 2015;Rippberger et al, 2015;. Therefore, the evaluation of the effects of drugs on psychostimulant (e.g., LDX)-induced increases in 50-kHz USVs is of great relevance in the research for antimanic drugs.…”

Section: Lisdexamfetamine (Ldx)-induced Increases In 50-khz Usvsmentioning

confidence: 99%

The antimanic-like effects of andrographolide and quercetin

Kanazawa¹

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Evaluation of 50-kHz ultrasonic vocalizations in animal models of mania: Ketamine and lisdexamfetamine-induced hyperlocomotion in rats

Cited by 25 publications

References 70 publications

Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study

Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study

Ketamine Differentially Attenuates Alcohol Intake in Male Versus Female Alcohol Preferring (P) Rats

The antimanic-like effects of andrographolide and quercetin

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