2020
DOI: 10.21203/rs.3.rs-30754/v3
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Evaluation of [68Ga]Ga-PSMA PET/CT Images Acquired with a Reduced Scan Time Duration in Prostate Cancer Patients using the Digital Biograph Vision

Abstract: Aim: [68Ga]Ga-PSMA-11 PET/CT allows for a superior detection of prostate cancer tissue, especially in the context of a low tumor burden. Digital PET/CT bears the potential of reducing scan time duration / administered tracer activity due to, for instance, its higher sensitivity and improved time coincidence resolution. It might thereby expand [68Ga]Ga-PSMA-11 PET/CT that is currently limited by 68Ge/68Ga-generator yield. Our aim was to clinically evaluate the influence of a reduced scan time duration in combin… Show more

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“…This is in line with a published clinical evaluation of 100 lesions, in which all lesions were detected at 60 s acquisition time, whereas at 30 s acquisition time single lesions were missed [34]. Moreover, comparable results indicating a threshold of 60 s per bed position were also obtained in phantom and clinical studies investigating 68 Ga-PSMA-11 PET/CT for imaging of prostate cancer patients [51,52].…”
Section: Discussionsupporting
confidence: 88%
“…This is in line with a published clinical evaluation of 100 lesions, in which all lesions were detected at 60 s acquisition time, whereas at 30 s acquisition time single lesions were missed [34]. Moreover, comparable results indicating a threshold of 60 s per bed position were also obtained in phantom and clinical studies investigating 68 Ga-PSMA-11 PET/CT for imaging of prostate cancer patients [51,52].…”
Section: Discussionsupporting
confidence: 88%
“…Analog hierzu konnte gezeigt werden, dass eine Reduktion der 68 Ga-PSMA-11 dPET Akquisitionszeit um einen Faktor von bis zu 3,5 möglich ist und die Detektionsrate pro anatomischer Region sowie die Quantifizierung trotzdem vergleichbar blieben. Es muss jedoch beachtet werden, dass kleine Läsionen bei der Reduktion der Scanzeit unter Umständen nicht erkannt werden können 20 . Gerade für die Bestimmung des Ganzkörper Tumorvolumens, das ein prädiktiver Biomarker für Patienten mit end-stage-Prostatakarzinom ist, könnte eine solche Reduktion der Akquisitionszeit bzw.…”
Section: Perspektivenunclassified