Evaluation of 7 Serum Biomarkers and Uterine Artery Doppler Ultrasound for First-Trimester Prediction of Preeclampsia: A Systematic Review

Kuć, Sylwia; Wortelboer, E. J.; Rijn, Bas B. van; Franx, Arie; Visser, Gerard H.A.; Schielen, Peter C. J. I.

doi:10.1097/ogx.0b013e3182227027

Cited by 170 publications

(149 citation statements)

References 104 publications

(200 reference statements)

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“…These include: ADAM12, a member of the ADAM protein family [68], present in the syncytiotrophoblast and involved in placental growth and development; free β-subunit of human chorionic gonadotropin, involved in the maintenance of the decidual spiral arteries and the vascular supply of the placenta [69]; inhibin A and activin A, which regulate hCG levels during pregnancy [70]; PP13, which plays a major role in the implantation of the blastocyst [71]; angiogenic factors, including antiangiogenic factors such as sFlt-1 and sEng secreted into the maternal circulation by a poorly implanted and ischemic placenta, and proangiogenic factors, such as PlGF and VEGF [72] and PAPP-A, which regulates the bioavailability of free IGF at the placenta-decidua interface during human implantation [73]. In a systematic review assessing the predictive potential of first trimester serum markers and of uterine artery Doppler findings, Kuc et al determined that the screening potential for each single serum marker was limited by a detection rate of approximately 10%, making them unsuitable for clinical practice [74]. However, a combination of inhibin A, PlGF, PAPP-A, uterine artery Doppler findings, and maternal characteristics (e.g., maternal age, BMI and ethnicity) increased the detection rates to almost 100% [75].…”

Section: Reviewmentioning

confidence: 99%

Flares of systemic lupus erythematosus during pregnancy and the puerperium: prevention, diagnosis and management

Stojan

Baer²

2012

Expert Review of Clinical Immunology

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Section: Reviewmentioning

confidence: 99%

Flares of systemic lupus erythematosus during pregnancy and the puerperium: prevention, diagnosis and management

Stojan

Baer²

2012

Expert Review of Clinical Immunology

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“…7 Several proteins indicative of abnormal placentation, such as placental growth factor (PlGF) and pregnancy-associated plasma protein A, have been demonstrated to be predictive of preeclampsia, especially preterm disease. 8 Novel plasma biomarkers, representative of placentation or the maternal vascular and inflammatory response in preeclampsia, may be discovered using an unbiased proteomic approach. Unfortunately, to date, most proteomic research, which has aimed to discover biomarkers, has failed to incorporate adequate biomarker validation studies in independent sample sets.…”

mentioning

confidence: 99%

Integrated Proteomics Pipeline Yields Novel Biomarkers for Predicting Preeclampsia

et al. 2013

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P reeclampsia continues to be a major cause of maternal mortality, resulting in >50 000 maternal deaths worldwide each year, and is the leading cause of iatrogenic preterm birth. 1To prevent preeclampsia, women at high risk of the condition need to be identified early in pregnancy. Although there is significant interest in the prediction of preeclampsia using combinations of clinical risk factors, biophysical measurements, and biochemical tests, to date no screening test has achieved the requisite sensitivity and specificity to be useful and costeffective in a clinical setting. 2-5Prediction of preeclampsia in healthy nulliparous women is particularly challenging, despite the greatest proportion of cases occurring in this population. The best known combination of markers tested in a low-risk nulliparous population had a sensitivity of 46% for a specificity of 80%, equating to a PPV of around 15.5%. 4 Other reports of better prediction have studied general obstetric populations that include high-risk women 3 or have used a nested case-control design with controls comprising uncomplicated pregnancies with the consequent overestimation of predictive performance. 6A screening test is likely to require multiple biomarkers that reflect different aspects of the complex pathological processes that culminate in preeclampsia.7 Several proteins indicative of abnormal placentation, such as placental growth factor (PlGF) and pregnancy-associated plasma protein A, have been demonstrated to be predictive of preeclampsia, especially preterm disease.8 Novel plasma biomarkers, representative of placentation or the maternal vascular and inflammatory response in preeclampsia, may be discovered using an unbiased proteomic approach. Unfortunately, to date, most proteomic research, which has aimed to discover biomarkers, has failed to incorporate adequate biomarker validation studies in independent sample sets. These are necessary steps in the translation of potential biomarkers into Abstract-Preeclampsia, a hypertensive pregnancy complication, is largely unpredictable in healthy nulliparous pregnant women. Accurate preeclampsia prediction in this population would transform antenatal care. To identify novel protein markers relevant to the prediction of preeclampsia, a 3-step mass spectrometric work flow was applied. On selection of candidate biomarkers, mostly from an unbiased discovery experiment (19 women), targeted quantitation was used to verify and validate candidate biomarkers in 2 independent cohorts from the SCOPE (SCreening fOr Pregnancy Endpoints) study. Candidate proteins were measured in plasma specimens collected at 19 to 21 weeks' gestation from 100 women who later developed preeclampsia and 200 women without preeclampsia recruited from Australia and New Zealand. Protein levels (n=25), age, and blood pressure were then analyzed using logistic regression to identify multimarker models (maximum 6 markers) that met predefined criteria: sensitivity ≥50% at 20% positive predictive value. These 44 algorithms were then tested i...

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“…Wysunięto następujące wnioski: obniżony poziom PAPP-A, PlGF, PP13 oraz podwyższony poziom inhibiny A między 8 a 13 tygodniem ciąży są statystycznie znamiennie związane z rozwojem stanu przedrzucawkowego po 20 tygodniu ciąży. Jednak jedynie zastosowanie odpowiednich algorytmów uwzględniających oprócz tych markerów biochemicznych również dane z wywiadu oraz UtA PI mogą być przydatne w ocenie ryzyka wystąpienia stanu przedrzucawkowego we wczesnej ciąży [60]. Brak jednoznacznej przyczyny odpowiedzialnej za rozwinięcie nadciśnienia tętniczego oraz stanu przedrzucawkowego.…”

Section: Badania Przesiewowe W Kierunku Nadciśnienia Indukowanego Ciąunclassified

Etiopathogenesis of hypertension in pregnant women

Maksym¹,

Madej²,

Lemm³

2015

Ann. Acad. Med. Siles.

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Nadciśnienie tętnicze w przebiegu ciąży jest jednym z najpoważniejszych powikłań ciąży i może stanowić zagrożenie dla życia ciężarnej oraz jej dziecka. W ostatnich latach coraz szerszym zainteresowaniem cieszą się badania nad profilaktyką nadciśnienia indukowanego ciążą, stanu przedrzucawkowego i rzucawki. Jednakże ze względu na nieznaną etiologię tych schorzeń pierwotna profilaktyka nie jest obecnie możliwa. W niniejszej pracy starano się przybliżyć stan wiedzy na temat etiopatogenezy oraz możliwości wczesnego wykrywania ciężarnych zagrożonych występowaniem tych zaburzeń.badania przesiewowe, etiopatogeneza, stan przedrzucawkowy, nadciśnienie indukowane ciążą A B S T R A C THypertension during pregnancy is one of the most severe complications of pregnancy and can cause materno-foetal morbidity and mortality. Research on preventing pregnancy-induced hypertension, preeclampsia and eclampsia has been gaining interest in recent years. However, due to the unknown etiology of these diseases, their prevention is currently not possible. The aim of this article is to explore current data on the etiopathogenesis of the aforementioned afflictions, as well as on the possibilities for their early diagnosis in pregnant women. K E Y W O R D Sscreening, etiopathogenesis, preeclamsia, pregnancy induced hypertension

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Evaluation of 7 Serum Biomarkers and Uterine Artery Doppler Ultrasound for First-Trimester Prediction of Preeclampsia: A Systematic Review

Cited by 170 publications

References 104 publications

Flares of systemic lupus erythematosus during pregnancy and the puerperium: prevention, diagnosis and management

Flares of systemic lupus erythematosus during pregnancy and the puerperium: prevention, diagnosis and management

Integrated Proteomics Pipeline Yields Novel Biomarkers for Predicting Preeclampsia

Etiopathogenesis of hypertension in pregnant women

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