Evaluation of 99mTc-labeled glutathione as a colon cancer targeting probe

Sidiq, Sumeera; Kumar, Ravi; Passi, Neelima D; Dhawan, D. K.; Shukla, Jaya; Mittal, Bhagwant Rai

doi:10.1007/s10967-020-07563-1

Cited by 1 publication

(3 citation statements)

References 25 publications

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“…Measuring the activity of GGT has also been achieved by alternative techniques, including bioluminescence, chemiluminescence, photoacoustic imaging (PAI), Raman, , ionizing-radiation-based techniques, like positron emission tomography (PET), − and magnetic resonance imaging (MRI). , In comparison with the responsive probes used for fluorescence measurements, the availability of probes employing these techniques for GGT measurements is limited. In this section, advances in the development of probes using these alternative techniques are summarized.…”

Section: Measuring Ggt By a Small-molecule-based Responsive Fluoresce...mentioning

confidence: 99%

“…Considering the fact of GGT overexpression in tumors, radiolabeling by radiocomplex has been reported for cancer diagnosis. For example, Sidiq et al reported the design of radiocomplex [ 99m Tc]Tc-GSH and evaluated its performance in labeling of colon cancer . In another study, Ye et al reported a GGT-activatable fluorine-18 labeled probe (Probe #41) for enhanced PET imaging of tumors .…”

Section: Measuring Ggt By a Small-molecule-based Responsive Fluoresce...mentioning

confidence: 99%

“…For example, Sidiq et al reported the design of radiocomplex [ 99m Tc]Tc-GSH and evaluated its performance in labeling of colon cancer. 92 In another study, Ye et al reported a GGT-activatable fluorine-18 labeled probe (Probe #41) for enhanced PET imaging of tumors. 91 In this study, a fluorine-18 labeled small-molecule probe, [ 18 F]γ-Glu-Cys-(StBu)-PPG(CBT)-AmBF 3 ( 18 F-1G), was synthesized.…”

Section: Measuring Ggt By Other Techniquesmentioning

confidence: 99%

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Advances and Perspectives of Responsive Probes for Measuring γ-Glutamyl Transpeptidase

Zhang,

et al. 2023

ACS Meas. Sci. Au

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Gamma-glutamyltransferase (GGT) is a plasma-membrane-bound enzyme that is involved in the γ-glutamyl cycle, like metabolism of glutathione (GSH). This enzyme plays an important role in protecting cells from oxidative stress, thus being tested as a key biomarker for several medical conditions, such as liver injury, carcinogenesis, and tumor progression. For measuring GGT activity, a number of bioanalytical methods have emerged, such as chromatography, colorimetric, electrochemical, and luminescence analyses. Among these approaches, probes that can specifically respond to GGT are contributing significantly to measuring its activity in vitro and in vivo. This review thus aims to highlight the recent advances in the development of responsive probes for GGT measurement and their practical applications. Responsive probes for fluorescence analysis, including "off−on", near-infrared (NIR), two-photon, and ratiometric fluorescence response probes, are initially summarized, followed by discussing the advances in the development of other probes, such as bioluminescence, chemiluminescence, photoacoustic, Raman, magnetic resonance imaging (MRI), and positron emission tomography (PET). The practical applications of the responsive probes in cancer diagnosis and treatment monitoring and GGT inhibitor screening are then highlighted. Based on this information, the advantages, challenges, and prospects of responsive probe technology for GGT measurement are analyzed.

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Section: Measuring Ggt By a Small-molecule-based Responsive Fluoresce...mentioning

confidence: 99%

Section: Measuring Ggt By a Small-molecule-based Responsive Fluoresce...mentioning

confidence: 99%

Section: Measuring Ggt By Other Techniquesmentioning

confidence: 99%

See 1 more Smart Citation

Advances and Perspectives of Responsive Probes for Measuring γ-Glutamyl Transpeptidase

Zhang,

et al. 2023

ACS Meas. Sci. Au

View full text Add to dashboard Cite

show abstract

Evaluation of 99mTc-labeled glutathione as a colon cancer targeting probe

Cited by 1 publication

References 25 publications

Advances and Perspectives of Responsive Probes for Measuring γ-Glutamyl Transpeptidase

Advances and Perspectives of Responsive Probes for Measuring γ-Glutamyl Transpeptidase

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