Evaluation of a Bioceramic as a Pulp Capping Agent In Vitro and In Vivo

Liu, Siyi; Wang, Sainan; Dong, Yanmei

doi:10.1016/j.joen.2014.12.009

Cited by 99 publications

(88 citation statements)

References 32 publications

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“…Biodentine ® , EndoSequence ® Root Repair Material and Portland cement (Lenherr et al 2012; Nazzal et al 2015). In vitro and in vivo studies have used bioceramics to demonstrate antibacterial effects (Elshamy et al 2016), biocompatibility to pulp tissue and induction of dental pulp cells proliferation and reparative dentine bridge formation (Liu et al 2015), whilst producing significantly less discolouration. It is certain that the recommendations for coronal seal material will change as more information on the suitability of these materials become available.…”

Section: Resultsmentioning

confidence: 99%

Interventions for the endodontic management of non-vital traumatised immature permanent anterior teeth in children and adolescents: a systematic review of the evidence and guidelines of the European Academy of Paediatric Dentistry

Duggal

Tong

Al-Ansary

et al. 2017

Eur Arch Paediatr Dent

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AimThis systematic review was undertaken in order to develop guidelines for the European Academy of Paediatric Dentistry for the management of non-vital permanent anterior teeth with incomplete root development.Methods Three techniques were considered; apexification by single or multiple applications of calcium hydroxide, use of Mineral Trioxide Aggregate (MTA) for the creation of an apical plug followed by obturation of the root canal, and finally a Regenerative Endodontic Technique (RET). Scottish Intercollegiate Guideline Network (SIGN) Guidelines (2008) were used for the synthesis of evidence and grade of recommendation.ResultsVariable levels of evidence were found and generally evidence related to these areas was found to be weak and of low quality. It was not possible to produce evidence-based guidelines based on the strength of evidence that is currently available for the management of non-vital immature permanent incisors.ConclusionsBased on the available evidence the European Academy of Paediatric Dentistry proposes Good Clinical Practice Points as a guideline for the management of such teeth. It is proposed that the long term use of calcium hydroxide in the root canals of immature teeth should be avoided and apexification with calcium hydroxide is no longer advocated. The evidence related to the use of a Regenerative Endodontic Technique is currently extremely weak and therefore this technique should only be used in very limited situations where the prognosis with other techniques is deemed to be extremely poor. The current review supports the use of MTA followed by root canal obturation as the treatment of choice.

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Section: Resultsmentioning

confidence: 99%

Interventions for the endodontic management of non-vital traumatised immature permanent anterior teeth in children and adolescents: a systematic review of the evidence and guidelines of the European Academy of Paediatric Dentistry

Duggal

Tong

Al-Ansary

et al. 2017

Eur Arch Paediatr Dent

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“…iRoot BP Plus was also found to be non-toxic to human dental pulp cells and was able to induce mineralization and odontoblastic differentiation-associated gene expression (197,198). In vitro and in vivo studies showed no significant difference in pulp response to iRoot BP Plus or MTA (189), consequently iRoot BP Plus might be used as a pulp capping material for vital pulp therapy (199). iRoot FS showed similar biocompatibility with iRoot BP Plus and ProRoot MTA, but it displayed the best cell adhesion capacity in both L929 and MG63 cells among iRoot BP Plus, ProRoot MTA and Super-EBA (194).…”

Section: Biological Propertiesmentioning

confidence: 99%

Bioceramic materials in endodontics

Wang¹

2015

Endodontic Topics

116

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During the past two decades, a number of major advances have been made in the field of bioactive ceramics used for endodontic treatment. This article reviews the physico‐chemical and biological properties of bioceramic materials and the application of bioceramic technology to endodontics. Bioceramic materials, with their biocompatible nature and excellent physico‐chemical properties, are widely used in endodontic applications. They can function as cements, root repair materials, root canal sealers and filling materials, which have the advantages of enhanced biocompatibility, potential increased root strength following obturation, antibacterial properties and sealing ability. New bioceramic materials have demonstrated the ability to overcome some of the significant limitations of earlier generations of endodontic materials. Most bioceramic materials have been shown to be biocompatible and have good physico‐chemical characteristics, therefore having a potential use in clinical endodontics. Although in vitro studies on the use of bioceramic materials in endodontics have given encouraging results, randomized and double‐blind clinical studies of sufficient length with these materials are needed to confirm long‐term success following their use.

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“…direct pulp capping in dental clinical practice. Previous studies demonstrated that MTA and bioceramics induce greater hard tissue formation compared with conventional calcium hydroxide materials (Liu et al 2015). Other reports also showed that MTA induced odontoblast-like cells beneath cavity preparations, and the dentine process contained induced tertiary dentine (Tran et al 2012).…”

Section: Introductionmentioning

confidence: 97%

Effect of tissue inhibitor of metalloprotease 1 on human pulp cells in vitro and rat pulp tissue in vivo

et al. 2019

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Aim To evaluate the dentinogenetic effects of tissue inhibitor of metalloprotease (TIMP1) on human pulp cells in vitro and rat pulp tissue in vivo. Methodology The effect of TIMP1 on pulp cell functions related to hard tissue formation as part of the wound healing process (i.e. biocompatibility, proliferation, differentiation and mineralized nodule formation) was evaluated in vitro and using a direct pulp capping experimental animal model in vivo. The effects of different‐sized cavity preparations on hard tissue formation induced by ProRoot MTA at 2 weeks were evaluated using micro‐computed tomography (micro‐CT). Tertiary dentine formation quality and quantity after pulp capping using TIMP1, ProRoot MTA and phosphate‐buffered saline (PBS) was also evaluated after 4 weeks using micro‐CT in term of dentine volume (DV), dentine mineral density (DVD) and histological analysis. The data were evaluated by Student's t‐test, one‐way ANOVA with Tukey's post hoc test, the Kruskal–Wallis test or the Steel–Dwass test. P values < 0.05 were considered statistically significant. Results TIMP1 significantly stimulated dental pulp stem cell proliferation, differentiation, and mineralization and was more biocompatible compared with the PBS control (P < 0.05). In the pulp capping model, the amount of tertiary dentine that formed was directly proportional to the size of the pulp exposure; greater amounts of tertiary dentine were observed in pulps with larger exposures after 2 weeks. 4‐week samples of TIMP1 and ProRoot MTA had similar characteristics, but both sample significantly induced tertiary dentine formation beneath the cavity compared with PBS (P < 0.05) under standardized cavity preparations. Conclusions TIMP1 has an important role in pulpal wound healing, which makes it a potential biological pulp capping material and candidate molecule for regenerative endodontic therapy.

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Evaluation of a Bioceramic as a Pulp Capping Agent In Vitro and In Vivo

Cited by 99 publications

References 32 publications

Interventions for the endodontic management of non-vital traumatised immature permanent anterior teeth in children and adolescents: a systematic review of the evidence and guidelines of the European Academy of Paediatric Dentistry

Interventions for the endodontic management of non-vital traumatised immature permanent anterior teeth in children and adolescents: a systematic review of the evidence and guidelines of the European Academy of Paediatric Dentistry

Bioceramic materials in endodontics

Effect of tissue inhibitor of metalloprotease 1 on human pulp cells in vitro and rat pulp tissue in vivo

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