Evaluation of a clinical risk index for advanced colorectal neoplasia among a North American population of screening age

Ruco, Arlinda; Stock, David; Hilsden, Robert J.; McGregor, S. Elizabeth; Paszat, Lawrence; Saskin, Refik; Rabeneck, Linda

doi:10.1186/s12876-015-0395-y

Cited by 10 publications

(13 citation statements)

References 24 publications

(34 reference statements)

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“…Of those, 50 records were excluded due to the inclusion and exclusion criteria. Finally, a total of 22 studies [28293040414243444546474849505152535455565758] were included, which evaluated 17 different risk scores. Detailed information of the selection process is presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

Risk Scores for Predicting Advanced Colorectal Neoplasia in the Average-risk Population: A Systematic Review and Meta-analysis

Peng

Weigl

Boakye

et al. 2018

American Journal of Gastroenterology

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OBJECTIVES:A systematic review and meta‐analysis was performed to summarize the available evidence on risk scores for predicting advanced colorectal neoplasia (advanced adenomas and cancer) in average‐risk and asymptomatic populations undergoing screening colonoscopy.METHODS:PubMed, EMBASE, and Web of Science databases were searched up to 28 March 2018. Studies that developed or validated a risk score to predict the risk of advanced colorectal neoplasia were included. Two reviewers independently extracted study characteristics including diagnostic performance indicators and assessed risk of bias and applicability in the included studies. Metaanalyses were conducted to determine the overall discrimination of risk scores evaluated by more than 1 study.RESULTS:A total of 22 studies including 17 original risk scores were identified. Risk scores included a median number of 5 risk factors. Factors most commonly included were age, sex, family history in first‐degree relatives, body mass index and smoking. The area under the receiver operating characteristic curve of risk scores ranged from 0.62 to 0.77 in the individual studies and from 0.61 to 0.70 in the meta‐analyses.CONCLUSIONS:Although the majority of available risk scores had relatively weak discriminatory power, they may be of some use for risk stratification in CRC screening. Rather than developing more risk scores based on environmental risk factors, future research should focus on exploring possibilities of enhancing predictive power by combining risk factor data with novel laboratory matters, such as polygenetic risk scores.

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Section: Resultsmentioning

confidence: 99%

Risk Scores for Predicting Advanced Colorectal Neoplasia in the Average-risk Population: A Systematic Review and Meta-analysis

Peng

Weigl

Boakye

et al. 2018

American Journal of Gastroenterology

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“…However, a recently published Canadian work showed that the risk index for advanced neoplasia using age, sex, family history of CRC, smoking history and BMI, as derived by Ruco et al[ 55 ], was less predictive of advanced neoplasia in the population of screening age in North America.…”

Section: European Colorectal Screening Scoring Systemmentioning

confidence: 99%

How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?

Suchánek¹,

Grega²,

Ngo³

et al. 2016

WJG

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The incidence and prevalence of metabolic syndrome (MS) and colorectal cancer (CRC) has been rising in developed countries. The association between these two diseases has been widely studied and reported. Less evidence is available about the relationship between MS and CRC precancerous lesions (adenomatous polyps, adenomas). The aim of this paper is to present an overview of our scientific understanding of that topic and its implication in clinical practice. One of the principal goals of current CRC secondary prevention efforts is to detect and remove the precancerous lesions in individuals with an average CRC risk to prevent the development of invasive cancer. MS is not currently considered a high-risk CRC factor and is therefore not included in the guidelines of organized screening programs. However, in light of growing scientific evidence, the approach to patients with MS should be changed. Metabolic risk factors for the development of adenomas and cancers are the same - obesity, impaired glucose tolerance, dyslipidemia, hypertension, cardiovascular diseases and diabetes mellitus type 2. Therefore, the key issue in the near future is the development of a simple scoring system, easy to use in clinical practice, which would identify individuals with high metabolic risk of colorectal neoplasia and would be used for individual CRC secondary prevention strategies. Currently, such scoring systems have been published based on Asian (Asia-Pacific Colorectal Screening Score; APCS) and Polish populations.

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“…A study performed on 1537 asymptomatic patients showed a prevalence of advanced neoplasia, which included cancer or a tubular adenoma, traditional serrated adenoma or sessile serrated adenoma with villous characteristics, and/or high-grade dysplasia and/or diameter ≥10 mm, of 6.8%. [ 19 ] The treatment is usually electrocautery removal performed through colonoscopy, like in our case. A rare, but important complication of giant polyps can be intussusception, as in the 2 cases presented by Avandipo.…”

Section: Discussionmentioning

confidence: 99%

Giant tubular adenoma with malignancy clinical characteristics in a female teenager

Mărginean

Mărginean²,

Simu³

et al. 2016

Medicine

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Background:Adenomas of the colon are usually benign tumors which carry a tendency for malignancy. These tumors can be villous, tubular, tubulovillous, or sessile serrated. Those with adenomatous structure can develop malignant characteristics in 1.5% to 9.4% of cases.Methods:We present a case report of a 16-year-old female adolescent with an adenoma of the descending colon. History revealed prolonged diarrheic syndrome for the past 6 months, repeated headache, and a weight loss of ∼5 kg in the past month. One week before the admission, the patient presented an episode of inferior digestive hemorrhage.Results:On admission laboratory tests revealed iron deficiency anemia, and a mildly increased erythrocyte sedimentation rate. The abdominal ultrasound revealed an inhomogeneous mass of the descending colon and 2 hyperechoic lesions in the liver. The colonoscopy showed a tumor of the descending colon, a tubular adenoma according to the pathological examination. Additionally, we noted an atypical presentation of the tumor and the signs of mild dysplasia identified at the pathological examination.Conclusion:Weight loss, bowel transit alterations, loss of appetite, and inferior hemorrhage in an adolescent can be symptoms of a benign or malignant tumor of the colon.

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Evaluation of a clinical risk index for advanced colorectal neoplasia among a North American population of screening age

Cited by 10 publications

References 24 publications

Risk Scores for Predicting Advanced Colorectal Neoplasia in the Average-risk Population: A Systematic Review and Meta-analysis

Risk Scores for Predicting Advanced Colorectal Neoplasia in the Average-risk Population: A Systematic Review and Meta-analysis

How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?

Giant tubular adenoma with malignancy clinical characteristics in a female teenager

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