Objective. To observe the effect of nursing communication ability in outpatient infusion room on the treatment experience of outpatients and their families and analyze whether improving nurses’ communication skills can reduce the incidence of doctor-patient disputes. Methods. According to the results of the communication ability survey, the outpatient nurses in our hospital are divided into groups A (
score
<
65
), B (
65
≤
score
<
80
), C (
80
≤
score
<
95
), and D (
score
≥
95
). Taking outpatients and their families in our hospital from September 2019 to December 2020 as the research objects, they were divided into corresponding groups according to the nurses who served them. Finally, there were 73 cases in group A, 85 in group B, 92 in group C, and 65 in group D. The mental toughness scale (Connor-Davidson Resilience Scale Chinese (CD-RISC)) scores and Herth Hope Index (HHI) scores of the four groups of patients were compared, and the correlation between nurse communication scores and CD-RISC scores and HHI scores was analyzed. The incidence of negative events (patient-nurse disputes, complaints, etc.) and the results of nursing satisfaction surveys during the visits of the four study groups were also counted. Results. The four groups of CD-RISC and HHI total scores were ranked from highest to lowest as groups D, C, B, and A, respectively (
P
<
0.05
). There was a positive correlation between the resilience dimension scores of the family members’ CD-RISC and the toughness, strength, optimism dimension scores of the HHI and the nurses’ communication dimension scores (
r
=
0.191
-0.472,
P
<
0.05
). Besides, the incidence of negative events was higher in group A than in the other three groups, while the satisfaction with care was lower than in the other three groups (
P
<
0.05
). Conclusion. Improving nurses’ communication skills in infusion room nursing quality management can improve the mental toughness and hope level of patients’ accompanying family members, which is conducive to controlling their emotions and avoiding the occurrence of dispute incidents.