Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control

Anil, Anu; Gujjari, Sheela Kumar; Venkatesh, M. P.

doi:10.4103/jisp.jisp_700_18

Cited by 16 publications

(10 citation statements)

References 36 publications

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“…The transmucosal route of drug delivery ensures that the potential therapeutic agent has a maximum contact period of the desired concentration while also ensuring better drug absorption. 26 Another study conducted by Kriplani et al about the efficacy of curcumin-containing patches for the treatment of osteoarthritis also indicated the efficacy of curcumin in providing anti-inflammatory as well as analgesic effects for inflammation of the bone. 27 Additionally, previous evaluations of the effective curcumin dose in humans have been reported.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Curcumin Patch as an Adjuvant Therapeutic Agent in Managing Acute Orofacial Pain on the Post-Cleft Lip and Cleft Palate Surgery Patients: A Pragmatic Trial

et al. 2022

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Objective Acute pain is one of the most common pains experienced by post-cleft lip or cleft surgery patients regardless of the administration of analgesic agents. This current study aimed to evaluate the efficacy of a curcumin patch as an adjuvant analgesic agent on the post-cleft lip and cleft palate surgery patients. Materials and Methods Fifty-five (33 male; 22 female) participants aged 36 months or less are recruited in this pragmatic trial and randomly assigned to a control group, where no curcumin patch was applied; or the experimental group, where the participants wore a curcumin patch with a dosage of 100mg. All participants (regardless of the group) received a standardized postsurgery analgesic agent immediately after the surgery was completed. A face, leg, activity, cry, and consolability (FLACC) scale was used to evaluate pain levels for three subsequent time points. Statistical Analysis All data were then analyzed by using the Mann–Whitney U test to compare the mean differences between the two groups. Results The results of the current study revealed that there was no significant difference found between the control and the experimental group when mean pain scores were compared for the first evaluation time. Yet, there was a significant difference (p<0.01) between the two groups' mean pain scores on the second evaluation time. Conclusion Curcumin patch was found to be effective when used as an adjuvant analgesic agent to reduce acute-orofacial postsurgery pain in cleft lip and cleft surgery patients.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Curcumin Patch as an Adjuvant Therapeutic Agent in Managing Acute Orofacial Pain on the Post-Cleft Lip and Cleft Palate Surgery Patients: A Pragmatic Trial

et al. 2022

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“…In another assessment, Anil et al 25 examined the effectiveness of a curcumin mucoadhesive film in reducing the rate of postsurgical pain. Their findings showed that the film was effective in reducing postoperative pain and swelling over the course of a week and also demonstrated its analgesic effect following periodontal surgeries.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Nano Micelles Curcumin and Ibuprofen on Pain Reduction After Initial Arch Wire Placement: A Double-Blind Randomized Clinical Trial Study

Shafaee

Ghiasi

Rahimi

et al. 2023

Journal of Advanced Oral Research

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Aim: To compare the effect of nano micelles curcumin and ibuprofen on pain reduction after primary arch wire placement in orthodontic patients. Materials and Methods: In this double-blind randomized clinical trial study, 60 female patients between the ages of 14 and 30 years who had moderate tooth crowding and were candidates for fixed orthodontic treatment were examined. The subjects were divided into four groups ( n = 15) of nano micelles curcumin (SinaCurcumin), ibuprofen, placebo of SinaCurcumin, and placebo of ibuprofen. Each patient received a questionnaire and a rectangular, flexible cube of silicone to record the severity of their pain under each of the three situations (biting posterior teeth together, fitting anterior teeth together, and without fitting the teeth together) at the designated time points (2 h, 6 h, bedtime, the second, third, and seventh days after archwire placement). The obtained outcomes were statistically verified and analyzed by the employment of SPSS Statistics Version 22. Results: despite the lack of any significant differences among the four groups in terms of pain severity upon biting by the anterior teeth 2 h after the intervention, there was a considerable difference in the cases of 6 h, bedtime, and the second, third, and seventh days subsequent of the placement of archwire. Our data indicated a lower rate of pain severity for SinaCurcumin group than the placebo of SinaCurcumin and ibuprofen groups at 6 h after the archwire placement. However, the pain severity of SinaCurcumin group at bedtime was significantly lower than ibuprofen group, which also resulted in a notably lower rate than the other groups at the second, third, and seventh days after the placement of archwire. Conclusion: These findings support the effectiveness of curcumin in reducing the pain severity of orthodontic patients. Nevertheless, it is a necessity to conduct further confirmation trials on this latter.

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“…Recently, Rahalkar et al showed that the application of curcumin gel followed by scaling and root planning (SRP) of the periodontal pocket remarkably reduced the PI in patients with periodontitis ( n = 15) compared to patients who underwent SRP alone . In a split-mouth pilot clinical trial, the application of curcumin mucoadhesive film (0.5%) remarkably reduced postsurgical pain and swelling and reduced the intake of analgesics in patients with periodontitis . In another study, Al-Aksar et al showed that supplementation with curcumin (500 mg) after surgical periodontal therapy in patients with stage 3/grade C periodontitis reduced pain and postoperative discomfort, though the differences were not remarkable between the curcumin and mefenamic acid (standard) treatment groups .…”

Section: Clinical Trials Of Turmeric and Curcuminmentioning

confidence: 92%

“…690 In a split-mouth pilot clinical trial, the application of curcumin mucoadhesive film (0.5%) remarkably reduced postsurgical pain and swelling and reduced the intake of analgesics in patients with periodontitis. 691 In another study, Al-Aksar et al showed that supplementation with curcumin (500 mg) after surgical periodontal therapy in patients with stage 3/grade C periodontitis reduced pain and postoperative discomfort, though the differences were not remarkable between the curcumin and mefenamic acid (standard) treatment groups. 692 Curcumin was found to be effective in patients having orthodontic implants by reducing plaque accumulation with no side effects.…”

Section: Turmeric and Curcumin In Inheritedmentioning

confidence: 99%

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

Kunnumakkara

Hegde

Dey

et al. 2023

ACS Pharmacol. Transl. Sci.

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Turmeric (Curcuma longa) has been used for thousands of years for the prevention and treatment of various chronic diseases. Curcumin is just one of >200 ingredients in turmeric. Almost 7000 scientific papers on turmeric and almost 20,000 on curcumin have been published in PubMed. Scientific reports based on cell culture or animal studies are often not reproducible in humans. Therefore, human clinical trials are the best indicators for the prevention and treatment of a disease using a given agent/drug. Herein, we conducted an extensive literature survey on PubMed and Scopus following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The keywords "turmeric and clinical trials" and "curcumin and clinical trials" were considered for data mining. A total of 148 references were found to be relevant for the key term "turmeric and clinical trials", of which 70 were common in both PubMed and Scopus, 44 were unique to PubMed, and 34 were unique to Scopus. Similarly, for the search term "curcumin and clinical trials", 440 references were found to be relevant, of which 70 were unique to PubMed, 110 were unique to Scopus, and 260 were common to both databases. These studies show that the golden spice has enormous health and medicinal benefits for humans. This Review will extract and summarize the lessons learned about turmeric and curcumin in the prevention and treatment of chronic diseases based on clinical trials.

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Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control

Cited by 16 publications

References 36 publications

The Efficacy of Curcumin Patch as an Adjuvant Therapeutic Agent in Managing Acute Orofacial Pain on the Post-Cleft Lip and Cleft Palate Surgery Patients: A Pragmatic Trial

The Efficacy of Curcumin Patch as an Adjuvant Therapeutic Agent in Managing Acute Orofacial Pain on the Post-Cleft Lip and Cleft Palate Surgery Patients: A Pragmatic Trial

Comparison of the Effects of Nano Micelles Curcumin and Ibuprofen on Pain Reduction After Initial Arch Wire Placement: A Double-Blind Randomized Clinical Trial Study

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

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