Evaluation of a cyano stationary phase for the determination of tacrolimus, sirolimus and cyclosporin A in whole blood by high-performance liquid chromatography–tandem mass spectrometry

Quantification of cyclosporine A in peripheral blood mononuclear cells by liquid chromatography-electrospray mass spectrometry using a column-switching approach

“…Several methods have recently been published for CsA quantification in whole blood in LC-MS/MS [20][21][22][23], however for TDM the use of single quadrupole MS method could be considered. The latter is simple, less expensive and can be used in most clinical laboratories with very good performance.…”

“…Therefore, it is preferable to use a separative method for the quantification of CsA. Several approaches using LC-UV, LC-MS or LC-MS/MS have been developed [19][20][21][22][23][24][25][26].…”

Development of a voltammetric method for the determination of rapamycin in pharmaceutical samples at pretreated pencil graphite electrode

“…Various methods are available for the determination of rapamycin in different types of samples. These include liquid chromatography/tandem mass spectrometry (LC MS/MS), [ 19–21 ] high performance liquid chromatography/UV–Vis (HPLC/UV), [ 22,23 ] HPLC/tandem mass spectrometry, [ 24,25 ] and directly coupling solid phase micro extraction to mass spectrometry via the microfluidic open interface (Bio‐SPME‐MOI‐MS/MS). [ 26 ] However, these traditional methods have some limitations such as high cost of tools and analysis, skilled manpower and large amounts of harmful solvents that become waste after analysis with most of them.…”