Evaluation of a direct systolic cardiac augmentation device on a canine heart during global postischemic dysfunction

Abstract

TABLE OF CONTENTS ACKNOWLEDGEMENTS ix CHAPTER I. INTRODUCTION 1 CHAPTER 2. LITERATURE REVIEW 4 Myocardial stunning 4 Description 4 Mechanism of development S Generation of oxygen-derived free radicals 5 Calcium overload 10 Excitation-contraction uncoupling due to sarcoplasmic reticulum dysfunction Other possible mechanisms Previous assist devices CHAPTER 3. DESCRIPTION OF THE HEART CUFF CHAPTER 4. OBJECTIVES OF THE STUDY