Evaluation of a Hemostatic Sponge (TachoSil<sup>®</sup>) for Sealing of the Renal Collecting System in a Porcine Laparoscopic Partial Nephrectomy Survival Model

Rané, Abhay; Rimington, Peter; Heyns, Chris F.; Merwe, André van der; Smit, S.; Anderson, Christopher J.

doi:10.1089/end.2009.0453

Cited by 17 publications

(12 citation statements)

References 12 publications

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“…At this time, the majority of published reviews of TachoSil in laparoscopic abdominal surgery have been limited to urologic surgery or splenic repair [47–49]. A report from Low and colleagues, describes the use of a liquid fibrin sealant and TachoSil to control a spontaneous splenic capsule rupture during a laparoscopic liver resection for colorectal metastasis [50].…”

Section: Resultsmentioning

confidence: 99%

Hemostatic Agents in Hepatobiliary and Pancreas Surgery: A Review of the Literature and Critical Evaluation of a Novel Carrier-Bound Fibrin Sealant (TachoSil)

et al. 2012

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Background. Despite progress in surgical techniques applied during hepatobiliary and pancreas (HPB) surgery, bleeding and bile leak remain significant contributors to postoperative mortality and morbidity. Topical hemostatics have been developed and utilized across surgical specialties, but data regarding effectiveness remains inconsistent and sparse in HPB surgery. Methods. A comprehensive search for studies and reviews on hemostatics in HPB surgery was performed via an October 2011 query of Medline, EMBASE, and Cochrane Library. In-depth evaluation of a novel carrier-bound fibrin sealant (TachoSil) was also performed. Results. The literature review illustrates multiple attempts have been made at developing different topical hemostatics and sealants to aid in surgical procedures. In HPB surgery, efforts have been directed at decreasing bleeding, biliary leakage, and pancreatic fistula. Conflicting scientific evidence exists regarding the effectiveness of these agents. Critical evaluation of the literature demonstrates TachoSil is a valuable tool in achieving hemostasis, and possibly biliostasis and pancreatic fistula prevention. Conclusion. While progress has been made in topical hemostatics for HPB surgery, an ideal agent has not yet been identified. TachoSil is promising, but larger randomized, controlled clinical trials are required to more fully evaluate its efficacy in reducing bleeding, biliary leakage, and pancreatic fistulas in HPB surgery.

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Section: Resultsmentioning

confidence: 99%

Hemostatic Agents in Hepatobiliary and Pancreas Surgery: A Review of the Literature and Critical Evaluation of a Novel Carrier-Bound Fibrin Sealant (TachoSil)

et al. 2012

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“…The most advanced gelatin‐based products consist on a combination of gelatin with other HAs, mostly biological agents like thrombin, and the processing of gelatin in different physical forms to broaden its range of applications (Bak et al, 2004; Echave, Oyagüez, & Casado, 2014; Frantz, 1946). Two examples of HAs in combination with gelatin and thrombin are FloSeal® (Rane et al, 2010) Hemostatic Matrix and Surgiflo®, composed of bovine and porcine‐derived gelatin, respectively, and human‐derived thrombin, which are nowadays routinely used by surgeons in many hospitals to aid in hemostasis control during LPN (Echave et al, 2014; Frantz, 1946; Gazzeri, Galarza, Morabito, et al, 2018; Hutchinson et al, 2015; Nogueira, Katz, Pinochet, Kurta, & Coleman, 2008). The mechanisms of action of these two products are similar, as both accelerate the clot formation by the activation of patients' endogenous fibrinogen, promoted by thrombin, and clot formation and platelet activation provided by the gelatin component.…”

Section: Has and Their Mechanisms Of Actionmentioning

confidence: 99%

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective

et al. 2020

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In recent years, there was an abrupt increase in the incidence of renal tumors, which prompt up the appearance of cutting-edge technology, including minimally invasive and organ-preserving approaches, such as laparoscopic partial nephrectomy (LPN). LPN is an innovative technique used to treat small renal masses that have been gaining popularity in the last few decades due to its promissory results. However, the bleeding control remains the main challenge since the majority of currently available hemostatic agents (HAs) used in other surgical specialities are inefficient in LPN. This hurried the search for effective HAs adapted for LPN surgical peculiarities, which resulted on the emergence of different types of topical HAs. The most promising are the natural origin HAs because of their inherent biodegradability, biocompatibility, and lowest toxicity. These properties turn them top interests' candidates as HAs in LPN. In this review, we present a deep overview on the progress achieved in the design of HAs based on natural origin polymers, highlighting their distinguishable characteristics and providing a clear understanding of their hemostat's role in LPN. This way it may be possible to establish a structure-composition properties relation, so that novel HAs for LPN can be designed to explore current unmet medical needs. K E Y W O R D S biodegradable hemostatic agents, hemostasis, laparoscopic partial nephrectomy, minimally invasive surgeries, renal cell carcinoma 1 | BACKGROUND Kidney cancer is a serious condition, in accordance with the International Agency for Research on Cancer (IARC) it is the 16th most common cause of cancer death and the prevalence has been increasing every year, making kidney cancer considered as a clinically signifi

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“…Цианакрилатные клеи имеют существенные недостатки: для на-дежной фиксации клея раневая поверхность должна быть высуше-на; кроме того, при их использовании могут возникать явления общей и местной токсичности, а также развивается зона некроза в месте нанесения клея [25]. При резекции почки химические клее-вые композиции и тканевые материалы применяются только в ка-честве дополнительного метода гемостаза после наложения гемо-статических швов, для полной остановки кровотечения, закрытия возможного дефекта ЧЛС и пластики дефекта органа [24,26].…”

Section: химические способы гемостаза при резекции почкиunclassified

“…Наиболее часто применяется большой сальник, причем как изолированно, так и на сосудистой ножке. Большой сальник можно применять для тампонады раны при глубоком раневом канале или в качестве прокладки для предупреждения прорезывания швов, накладыва-емых на паренхиматозный орган [26].…”

Section: биологические методы гемостазаunclassified

Hemostatic techniques for kidney resection

Safronova¹,

Krasheninnikov²,

Сергиенко³

et al. 2016

Onkol. Z. im. P.A. Gercena

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renal cell carcinoma is an urgent problem in urologic oncology practice. The wide use of radiodiagnostic methods has increased the detection rate of small localized tumors, leading to an increase in the number of patients, for whom organ-sparing surgery is indicated. Kidney resection is the most common, effective, and relatively safe treatment option in this contingent of patients. At the same time, kidney resection is related to the need for hemostasis during operations on the actively vascularized organ. Thus, adequate hemostasis is the most important surgical stage during kidney resection. hemostatic procedures are diverse and include different mechanical, physical, and chemical exposures of the vascularized parenchyma of the organ. The literature covering different hemostatic techniques during kidney resection are reviewed. The results of large-scale studies assessing different hemostatic procedures are given.

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Evaluation of a Hemostatic Sponge (TachoSil^®) for Sealing of the Renal Collecting System in a Porcine Laparoscopic Partial Nephrectomy Survival Model

Abstract: TachoSil seals the collecting system after partial nephrectomy on a porcine chronic survival model, in addition to providing an adjunct to hemostasis. More studies, including human trials, are warranted to evaluate this observation further.

Cited by 17 publications

References 12 publications

Hemostatic Agents in Hepatobiliary and Pancreas Surgery: A Review of the Literature and Critical Evaluation of a Novel Carrier-Bound Fibrin Sealant (TachoSil)

Hemostatic Agents in Hepatobiliary and Pancreas Surgery: A Review of the Literature and Critical Evaluation of a Novel Carrier-Bound Fibrin Sealant (TachoSil)

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective

Hemostatic techniques for kidney resection

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Evaluation of a Hemostatic Sponge (TachoSil®) for Sealing of the Renal Collecting System in a Porcine Laparoscopic Partial Nephrectomy Survival Model

Abstract: TachoSil seals the collecting system after partial nephrectomy on a porcine chronic survival model, in addition to providing an adjunct to hemostasis. More studies, including human trials, are warranted to evaluate this observation further.

Cited by 17 publications

References 12 publications

Hemostatic Agents in Hepatobiliary and Pancreas Surgery: A Review of the Literature and Critical Evaluation of a Novel Carrier-Bound Fibrin Sealant (TachoSil)

Hemostatic Agents in Hepatobiliary and Pancreas Surgery: A Review of the Literature and Critical Evaluation of a Novel Carrier-Bound Fibrin Sealant (TachoSil)

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective

Hemostatic techniques for kidney resection

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Evaluation of a Hemostatic Sponge (TachoSil^®) for Sealing of the Renal Collecting System in a Porcine Laparoscopic Partial Nephrectomy Survival Model