Evaluation of a High Sodium - Low Potassium Cold-Storage Solution Using the Isolated Perfused Rat Kidney

Ramella, S.; Hadj-Aïssa, A.; Barbieux, A.; Steghens, Jean Paul; Colpart, J. J.; Zech, P; Pozet, N

doi:10.1007/978-94-011-0201-8_60

Cited by 16 publications

(27 citation statements)

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“…Both rat and porcine transplantation studies of liver and kidney have shown encouraging results in terms of organ function after transplantation following preservation with IGL-1 (41,69,101). The first preliminary clinical results in renal transplantation with IGL-1 demonstrated a reduction in DGF compared to kidneys preserved with UW-CSS (5.7% vs. 13.8%, respectively).…”

Section: New Solutionsmentioning

confidence: 86%

Perspectives in Organ Preservation

2007

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Maintaining organ viability after donation until transplantation is critically important for optimal graft function and survival. To date, static cold storage is the most widely used form of preservation in every day clinical practice. Although simple and effective, it is questionable whether this method is able to prevent deterioration of organ quality in the present era with increasing numbers of organs retrieved from older, more marginal, and even non-heart-beating donors. This review describes principles involved in effective preservation and focuses on some basic components and methods of abdominal organ preservation in clinical and experimental transplantation. Concepts and developments to reduce ischemia related injury are discussed, including hypothermic machine perfusion. Despite the fact that hypothermic machine perfusion might be superior to static cold storage preservation, organs are still exposed to hypothermia induced damage. Therefore, recently some groups have pointed at the beneficial effects of normothermic machine perfusion as a new perspective in organ preservation and transplantation.

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Section: New Solutionsmentioning

confidence: 86%

Perspectives in Organ Preservation

2007

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“…The K-UW solution is the original Belzer liquid without dexamethasone, insulin and antibiotics and was modified in a stepwise fashion. The Na-UW solution [6] contains all the ingredients of the K-UW solution but with inverted concentrations of K + and Na + . IGL-1 solution is the result of PEG-35 (0.03 mM) substitution for HES (0.25 mM, MW 200,000) in the Na-UW solution.…”

Section: Preservation Solutionsmentioning

confidence: 99%

“…Although University of Wisconsin (UW) solution was introduced to decrease ischemic graft damage [5], the beneficial effects of storage in this solution do not completely prevent cellular and interstitial swelling and reperfusion-induced oedema. Our previous studies [6] demonstrated that it is possible to improve cold-preservation solutions by modifying the UW solution composition: the simple inversion of K + and Na + concentrations in UW solution improves rat liver function [7] as well as rat kidney function [8]. In addition, an improvement of all functional parameters of the liver has been demonstrated using a cold preservation solution where polyethylene glycol (PEG) was substituted for hydroxylethyl starch (HES) in the extracellular UW solution [9].…”

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confidence: 99%

Effect of IGL-1, a new preservation solution, on kidney grafts (a pre-clinical study)

et al. 2005

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Ischemia-reperfusion injury conditions short-term and long-term graft function. The effects of the inversion of K+ and Na+ concentrations and substitution with polyethylene glycol for hydroxyethyl starch in University of Wisconsin (K-UW) solution were evaluated in isolated perfused rat kidneys and in autotransplanted pig kidneys. In the rat model kidneys were cold-stored for 24 h in K-UW or Na-UW or Na-PEG UW solutions (IGL-1 solution). Fractional sodium reabsorption and glomerular filtration rate was better in kidneys preserved in Na-UW and IGL-1 solution than those preserved in K-UW solution. In the pig model the left kidney was harvested and preserved in K-UW or IGL-1 solution for 24 h and then transplanted. In the autotransplanted pig model, kidneys preserved in IGL-1 solution showed a better function and a significant reduction of MHC class II expression, cellular apoptosis and interstitial fibrosis. In conclusion, kidneys preserved in IGL-1 solution tolerated ischemia/reperfusion injury better than those preserved in K-UW solution.

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“…The K-UW solution is the original Belzer liquid without dexamethasone, insulin and antibiotics and was modified in a stepwise fashion. The Na-UW solution [6] contains all the ingredients of the K-UW solution but with inverted concentrations of K + and N a f . IGL-1 solution is the result of PEG-35 (0.03 mM) substitution for HES (0.25 mM, MW 200,000) in the Na-UW solution.…”

Section: Preservation Solutionsmentioning

confidence: 99%

“…Although University of Wisconsin (UW) solution was introduced to decrease ischemic graft damage [5], the beneficial effects of storage in this solution do not completely prevent cellular and interstitial swelling and reperfusion-induced oedema. Our previous studies [6] demonstrated that it is possible to improve cold-preservation solutions by modifying the UW solution composition: the simple inversion of K + and N a + concentrations in UW solution improves rat liver function [7] as well as rat kidney function [8]. In addition, an improvement of all functional parameters of the liver has been demonstrated using a cold preservation solution where polyethylene glycol (PEG) was substituted for hydroxylethyl starch (HES) in the extracellular UW solution [9].…”

Section: Introductionmentioning

confidence: 97%

Effect of IGL-1, a new preservation solution, on kidney grafts (a pre-clinical study)

et al. 2004

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Ischemia-reperfusion injury conditions short-term and longterm graft function. The effects of the inversion of K + and N a + concentrations and substitution with polyethylene glycol for hydroxyethyl starch in University of Wisconsin (K-UW) solution were evaluated in isolated perfused rat kidneys and in autotransplanted pig kidneys. In the rat model kidneys were cold-stored for 24 h in K-UW or Na-UW or Na-PEG UW solutions (IGL-I solution). Fractional sodium reabsorption and glomerular filtration rate was better in kidneys preserved in Na-UW and IGL-1 solution than those preserved in K-UW solution. In the pig model the left kidney was harvested and preserved in K-UW or IGL-1 solution for 24 h and then transplanted. In the autotransplanted pig model, kidneys preserved in IGL-1 solution showed a better function and a significant reduction of MHC class I1 expression, cellular apoptosis and interstitial fibrosis.In conclusion, kidneys preserved in IGL-I solution tolerated ischemia/ reperfusion injury better than those preserved in K-UW solution.

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Evaluation of a High Sodium - Low Potassium Cold-Storage Solution Using the Isolated Perfused Rat Kidney

Cited by 16 publications

References 0 publications

Perspectives in Organ Preservation

Perspectives in Organ Preservation

Effect of IGL-1, a new preservation solution, on kidney grafts (a pre-clinical study)

Effect of IGL-1, a new preservation solution, on kidney grafts (a pre-clinical study)

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