Evaluation of a hyaluronic acid hydrogel (Restylane Lyft) as a scaffold for dental pulp regeneration in a regenerative endodontic organotype model

AlHowaish, Norah A.; Al-Sudani, Dina; AlMuraikhi, Nihal

doi:10.1007/s10266-022-00710-y

Cited by 11 publications

(10 citation statements)

References 37 publications

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“…They are easy to acquire, handle, and insert into the root canal. These dermal fillers have undergone in vitro assessments in previous investigations [25,26].…”

Section: Discussionmentioning

confidence: 99%

“…Restylane Lyft is an HA-based sterile hydrogel that is FDA approved and commercially available as an injectable dermal/subdermal filler. Previous studies have shown promising results with regard to Restylane and Restylane Lyft when used as a scaffold for REPs in vitro [25,26]. However, to the best of our knowledge, to date, no study has investigated the performance of a Restylane Lyft scaffold in REPs in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, they are commercially available and involve controlled preparations that have been approved by the Food and Drug Administration (FDA) [24]. They can be easily injected as scaffolds into root canals in REPs. HA-based hydrogel has been demonstrated to have promising potential in promoting cell viability, mineralization, and differentiation into odontoblastic-like cells [25,26].…”

Section: Introductionmentioning

confidence: 99%

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Histological Evaluation of Restylane Lyft Used as a Scaffold for Dental Pulp Regeneration in Non-Infected Immature Teeth in Dogs

et al. 2022

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Commercially available hyaluronic acid dermal fillers used as a scaffold in regenerative endodontic procedures (REPs) have demonstrated attractive potentials. This study aimed to histologically evaluate the outcome of REPs using Restylane Lyft (HA) as a scaffold. REPs were performed on pulpless, immature roots in dogs (n = 69). The roots were divided into four groups: blood clot (BC), Restylane Lyft (BC + HA), negative control, and positive control. At 13 weeks postoperatively, hard tissue formation, vascularization, the presence of vascularized soft connective tissue and collagen fibers, the degree of inflammation within pulp spaces and/or periapical tissues, and apical closure were evaluated histologically. The vascularization and formation of loosely arranged collagen fibers within the regenerated soft connective tissues were observed significantly more in the BC+HA group (85% and 40%, respectively; p < 0.05) compared to the BC group (54.6% and 9.1%, respectively; p < 0.05). The degree of inflammation was significantly higher in the HA group than in the BC group; moderate to severe inflammatory cell infiltration was seen in 45% and 13.6% of the cases, respectively. The results of the present study suggest that Restylane Lyft combined with a blood clot used as a scaffold may improve the outcomes of REPs in non-infected, pulpless, immature teeth in dogs.

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“…They are easy to acquire, handle, and insert into the root canal. These dermal fillers have undergone in vitro assessments in previous investigations [25,26].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Histological Evaluation of Restylane Lyft Used as a Scaffold for Dental Pulp Regeneration in Non-Infected Immature Teeth in Dogs

et al. 2022

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“…Several authors recommend viscous gels to obtain a polymer film on the lesion [ 12 ], which helps pain relief during aphthous lesion formation and thus diminishes the healing time [ 13 , 14 , 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Performance Evaluation of a Hyaluronic Acid Dental Gel for the Treatment of Traumatic Ulcers in Patients with Fixed Orthodontic Appliances: A Randomized Controlled Trial

et al. 2022

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Background: A newly available gel containing hyaluronic acid (HA) and polyvinylpyrrolidone was tested for efficacy on traumatic oral ulcers (TOU) caused by fixed orthodontic appliances. Methods: A double-blind RCT was conducted to test the new gel versus a placebo. According to the sample size calculation, a total of 60 patients were considered sufficient and randomly allocated to one of the two groups out of a pool of 100 total patients who initially agreed to participate in the study. A VAS scale test and lesion measurements at T0, T1, and T2 were performed on the patients. Results: A total of 70 patients developed TOU, with 8 drop-outs; the intergroup comparison showed a statistically significant greater dimension of the lesion in the control group at T2 when compared to the test group. The pain experienced by the patients belonging to the test group was significantly lower than the pain in the patients in the control group Conclusions: Under the limitations of the study, the new formula might provide faster healing with less pain experienced by the patient when compared to a placebo.

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“…Furthermore, Hyaluronic acid is biocompatible and biodegradable making it a potential scaffold for dental pulp regeneration. (4)…”

Section: Introductionmentioning

confidence: 99%

Regenerative Endodontic Treatment of Mature Necrotic Permanent Teeth Using Hyaluronic Acid Gel: A Case Report

Abdalla

Moussa

Mokhless

et al. 2023

Alexandria Dental Journal

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Evaluation of a hyaluronic acid hydrogel (Restylane Lyft) as a scaffold for dental pulp regeneration in a regenerative endodontic organotype model

Cited by 11 publications

References 37 publications

Histological Evaluation of Restylane Lyft Used as a Scaffold for Dental Pulp Regeneration in Non-Infected Immature Teeth in Dogs

Histological Evaluation of Restylane Lyft Used as a Scaffold for Dental Pulp Regeneration in Non-Infected Immature Teeth in Dogs

Clinical Performance Evaluation of a Hyaluronic Acid Dental Gel for the Treatment of Traumatic Ulcers in Patients with Fixed Orthodontic Appliances: A Randomized Controlled Trial

Regenerative Endodontic Treatment of Mature Necrotic Permanent Teeth Using Hyaluronic Acid Gel: A Case Report

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