Evaluation of a New Biosensor Based on in Situ Synthesized PPy-Ag-PVP Nanohybrid for Selective Detection of Dopamine

Abstract

In the present work, in situ synthesis of polypyrrole-silver-polyvinylpyrrolidone (PPy-Ag-PVP) nanohybrid using AgNO as an oxidant and polyvinylpyrrolidone (PVP) as a stabilizer and surfactant is demonstrated. The obtained ternary PPy-Ag-PVP nanohybrid was characterized by UV-vis, FT-IR, XRD, Raman, TGA, SEM, and HR-TEM analysis. Further the synthesized PPy-Ag-PVP has been investigated for its selective and sensitive sensing of dopamine (DA). The PPy-Ag-PVP modified glassy carbon electrode shows a reversible electrochemical behavior with superior response for DA. The limit of detection and limit of quantification are found to be 0.0126 and 0.042 μM (S/N = 3 and 10), respectively, with remarkable sensitivity (7.26 μA mM cm). The practical application of the present modified electrode has been validated by determining the concentration of DA in human urine samples of different age group.

Facile preparation of a cellulose microfibers–exfoliated graphite composite: a robust sensor for determining dopamine in biological samples

“…To explain the advantages and novelty of the sensor, the analytical parameters of the sensor was compared with existing DA sensors and comparative results are shown in Table 1. As can be seen that the fabricated DA sensor exhibited a lower LOD, higher sensitivity, and a wider linear range in the detection of DA than previously reported DA sensors using different composite modified electrodes (Palanisamy et al 2013;Palanisamy et al 2016a;Palanisamy et al 2016b;Shanbhag et al 2017;Xu et al 2017;Caetano et al 2017;Rahman et al 2017;Haldorai et al 2017;Yang et al 2017;Fang et al 2017;Daemia et al 2017;Wang et al 2017;Zhang et al 2017;Vellaichamy et al 2017b). Accordingly, graphite-CMF composite modified SPCE represent an alternative sensitive catalyst for low-level detection of DA.…”

“…Although DA is a highly electroactive molecule, interactions with unmodified electrodes exhibit low sensitivity, poor selectivity, and surface fouling, effectively limiting their practical application in electrochemical sensing (Thirumalraj et al 2016). Consequently, carbon nano/micro materials, metal nanoparticles, transition metal oxides, and conducting polymer-based composite modified electrodes (including carbon nanotubes, graphene and its derivatives) are widely applied for different potential applications including the determination of DA (Vellaichamy et al 2017a;Vellaichamy and Prakash 2016;Vellaichamy et al 2017b;Jacobs et al 2010;Sajid et al 2016;Yang et al 2015).…”

AgNP/crystalline PANI/EBP‐composite‐based supercapacitor electrode with internal chemical interactions

“…Notably, after AgNPs were added, intensities of all peaks in Raman spectra were drastically enhanced. This result is in good agreement with earlier reported literatures . From all these results, it can be inferred that PANI is successfully formed in the composite electrodes.…”

Palladium Nanoparticles Decorated Graphene Oxide: Active and Reusable Nanocatalyst for the Catalytic Reduction of Hexavalent Chromium(VI)

“…Pd/GO was prepared with high reproducibility through ( i ) H 2 reduction of Pd(dba) 2 (dba=dibenzylideneacetone) in the presence of APTS (APTS=3‐aminopropyltriethoxysilane) in THF to yield colloidal APTS stabilized Pd NPs and then ( ii ) their immobilization onto the surface of graphene oxide (GO) by impregnation. Graphene oxide (GO) has been selected as host support material owing to not only its large surface area, high thermal/oxidation stability but also ultra‐high dispersion of metal NPs on its surface due to resulting from “Strong Metal Support Interaction” (SMSI) ,. The characterization of Pd/GO was done by using inductively coupled plasma‐optical emission spectroscopy (ICP‐OES), powder X‐ray diffraction (P‐XRD), X‐ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), bright‐field transmission electron microscopy (BFTEM), high resolution transmission electron microscopy (HRTEM), and transmission electron microscope‐energy dispersive X‐ray (TEM‐EDX) techniques.…”