Evaluation of a New Brain Tissue Probe for Intracranial Pressure, Temperature, and Cerebral Blood Flow Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage

Seule, Martin; Sikorski, Christopher; Sakowitz, Oliver W.; Campe, Gord von; Santos, Edgar; Orakcioglu, Berk; Unterberg, Andreas; Keller, Emanuela

doi:10.1007/s12028-016-0284-4

Cited by 22 publications

(9 citation statements)

References 28 publications

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“…The standard of care, therefore, involves the invasive component required, and additional monitoring requires only adaptation of the systems already established, with minimal additional risk burden to patients. An example of this principle is the integration of a near-infrared spectroscopy probe with ICP monitoring [ 105 ]. This device has utilised existing intracranial access to introduce an optical monitoring modality for the assessment of cerebral haemodynamics, successfully implemented in a small pilot group without safety concerns.…”

Section: Discussionmentioning

confidence: 99%

Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives

Stevens

Stickland

Harris

et al. 2022

Cells

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Traumatic brain injury (TBI) is a significant global health problem, for which no disease-modifying therapeutics are currently available to improve survival and outcomes. Current neuromonitoring modalities are unable to reflect the complex and changing pathophysiological processes of the acute changes that occur after TBI. Raman spectroscopy (RS) is a powerful, label-free, optical tool which can provide detailed biochemical data in vivo. A systematic review of the literature is presented of available evidence for the use of RS in TBI. Seven research studies met the inclusion/exclusion criteria with all studies being performed in pre-clinical models. None of the studies reported the in vivo application of RS, with spectral acquisition performed ex vivo and one performed in vitro. Four further studies were included that related to the use of RS in analogous brain injury models, and a further five utilised RS in ex vivo biofluid studies for diagnosis or monitoring of TBI. RS is identified as a potential means to identify injury severity and metabolic dysfunction which may hold translational value. In relation to the available evidence, the translational potentials and barriers are discussed. This systematic review supports the further translational development of RS in TBI to fully ascertain its potential for enhancing patient care.

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Section: Discussionmentioning

confidence: 99%

Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives

Stevens

Stickland

Harris

et al. 2022

Cells

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“…For nearly 20 years, Emanuela Keller and her neuro-ICU team—as part of the neurosurgical department—have made substantial contributions to the success of the department. Emanuela Keller has conducted and contributed to research on multimodal cerebral monitoring (including data mining and cognitive computing), and the optimisation of neuroprotective therapies and inflammatory responses after SAH [ 61 , 79 ].…”

Section: Discussionmentioning

confidence: 99%

UniversitätsSpital Zürich: 80 years of neurosurgical patient care in Switzerland

et al. 2017

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BackgroundThe predecessor of today’s Department of Neurosurgery, UniversitätsSpital Zürich (USZ), was founded 80 years ago as the first independent Swiss clinic dedicated to neurosurgical patient care. On the occasion of this anniversary, we aimed to highlight the history of neurosurgery as a specialty at the USZ, and to put it into the historical context of Swiss and European Neurosurgery.MethodA literature review was conducted and we searched the archives of the USZ and the city of Zurich, as well as those of Swiss journals to extract relevant published articles, books, historical reports and pictures. The USZ Department of Medical History, the Museum of Medical History and the Swiss National Library were contacted to provide source material. To further verify the content, (emeritus) faculty from the USZ and external experts on the history of Swiss neurosurgery reviewed the manuscript.ResultsSurgeries of the head and spine had occasionally been conducted in Zurich by the general surgeons, Rudolf Ulrich Krönlein and Paul Clairmont, before an independent neurosurgical clinic was founded by Hugo Krayenbühl on 6 July 1937. This was the first Swiss department dedicated to neurosurgical patient care. Besides providing high-quality medicine for both the local and wider population, the department was chaired by eminent leaders of neurosurgery, who influenced the scientific and clinical neurosurgery of their time. As such, it has long been regarded as one of the top teaching and research hospitals in Switzerland and in Europe.ConclusionsOn the occasion of its 80th anniversary, we have performed an in-depth review of its development, successes and challenges, with a special focus on the early decades. Reflecting on the past, we have identified common denominators of success in neurosurgery that remain valid today.Electronic supplementary materialThe online version of this article (10.1007/s00701-017-3357-z) contains supplementary material, which is available to authorised users.

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“…16 Optical imaging with NIRS provides continuous monitoring of oxyhemoglobin and deox-yhemoglobin and serial measurements of CBF with the NIRS and ICG dye dilution method. The light source and detector electronics are included in the NeMo Control Unit (NeMoDevices AG).…”

Section: Measurement Techniquementioning

confidence: 99%

Evaluation of a New Brain Tissue Probe for Cerebral Blood Flow Monitoring in an Experimental Pig Model

et al. 2016

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Background: Bedside monitoring of cerebral blood flow (CBF) may provide new insights into the pathophysiology of brain injury, allow early detection of secondary ischemia, and help guide therapy. Objective: To evaluate a new brain tissue probe for serial CBF monitoring using near-infrared spectroscopy Indocyanine green dye dilution (NeMo Probe) com-pared with the existing thermal diffusion probe (QFlow 500 Probe). Methods: In 7 pigs, the NeMo Probe and QFlow 500 Probe were inserted into the subcortical white matter. Parallel measurements were recorded during [1] baseline, [2] hypotension, [3] hypertension, and [4] hyperventilation. Thereafter, protocol points 1 through 4 were repeated once. The Spearman correlation (rs), Bland-Altman plot, concordance rate, and coefficient of variation were used for statistical analysis. Results: There was poor agreement between 56 pairs of absolute CBF values (rs = 0.52, P < .001). The mean bias was 10.7 ml/100 g/min with limits of agreement of 233.0 to·54.3 ml/100 g/min. The analysis of 49 pairs of changes in CBF showed a good·correlation (rs = 0.83, P <.001), and the concordance rate was 93.3%. The coefficient of variation from repeated measurements under comparable physiological conditions was 51.6% for the QFlow 500 Probe and 12.9% for the NeMo Probe. Conclusion: Absolute CBF values obtained with the NeMo Probe and QFlow 500 Probe cannot be interpreted as equivalent. However, the NeMo Probe provides acceptable trending ability and reproducibility from repeated measurements, whereas the reproducibility of the QFlow 500 Probe was poor. Future clinical studies are warranted to evaluate the NeMo Probe in the setting of acute brain injury.

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Evaluation of a New Brain Tissue Probe for Intracranial Pressure, Temperature, and Cerebral Blood Flow Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage

Cited by 22 publications

References 28 publications

Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives

Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives

UniversitätsSpital Zürich: 80 years of neurosurgical patient care in Switzerland

Evaluation of a New Brain Tissue Probe for Cerebral Blood Flow Monitoring in an Experimental Pig Model

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