Evaluation of a New Carotid Intima-Media Thickness Measurement by B-Mode Ultrasonography Using an Innovative Measurement Software, Intimascope

Yanase, Toshihiko; Nasu, Shigeru; Mukuta, Yoshihiro; Shimizu, Yutaka; Nishihara, Tetsu; Okabe, Taijiro; Nomura, Masatoshi; Inoguchi, Toyoshi; Nawata, Hajime

doi:10.1016/j.amjhyper.2006.05.010

Cited by 101 publications

(93 citation statements)

References 23 publications

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“…The  between the M and the SA measurements found in our study was not high (see Table 3), while =0.86 [44] , =0.72 [45] with lower SD for the SA method, =0.74 [46] , whereas where 2,146 participants took place =0.34 [47] . In Ref.…”

Section: Discussionmentioning

confidence: 72%

An integrated system for the complete segmentation of the common carotid artery bifurcation in ultrasound images

Loizou

Pantziaris

2015

JBEI

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The complete segmentation of the common carotid artery (CCA) bifurcation in ultrasound images is important for the evaluation of atherosclerosis disease and the quantification of the risk of stroke. The current research work further evaluates and validates a semi-automated (SA) snake's based segmentation system suitable for the complete segmentation of the CCA bifurcation in two-dimensional (2D) ultrasound images. The proposed system semi-automatically estimates the intima-media thickness (IMT), the atherosclerotic carotid plaque borders and dimensions, the internal carotid artery (ICA) origin's stenosis, the carotid diameter (D), as well as other geometric measurements of the atherosclerotic carotid plaque. The system was evaluated on 300 2D longitudinal ultrasound images of the CCA bifurcation with manual (M) segmentations available from a neurovascular expert. No statistical significant differences between all M and SA IMT, plaque and D segmentation measurements were found. In a future study, texture features extracted from the intima-media complex (IMC) may be used to separate subjects in high and low risk groups, which may develop a stroke. However, a larger scale study is required for evaluating the system before its application in the real clinical practice.

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Section: Discussionmentioning

confidence: 72%

An integrated system for the complete segmentation of the common carotid artery bifurcation in ultrasound images

Loizou

Pantziaris

2015

JBEI

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“…The intima-media thickness was defined as the distance between the media-adventitia interface and the lumen-intima interface, and was measured 20 mm proximal to the origin of the carotid bulb using the intima-media thickness measurement software (Intimascope; Media Cross Co., Tokyo, Japan). 11 The C-IMT was the mean value of 99 computer-based points in the region. The same investigator performed all the ultrasonographic procedures used to estimate the C-IMT.…”

Section: Ultrasonographic Measurement Of Carotid Intima-media Thicknementioning

confidence: 99%

High fat stores in ectopic compartments in men with newly diagnosed type 2 diabetes: an anthropometric determinant of carotid atherosclerosis and insulin resistance

et al. 2009

Int J Obes

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Objective: The objective of this study was to analyze how fat partitioning in the liver, muscle and visceral compartments is altered by diabetes and age, and whether altered fat distribution is associated with a higher carotid artery intima-media thickness (C-IMT) and insulin resistance. Methods: This was an observational study performed on 21 young healthy men (mean age±s.d., 28.6±3.8 years) and 73 men with newly developed type 2 diabetes (38 young (29.2 ± 4.1 years) and 35 middle-aged (47.1 ± 6.0 years) subjects). Abdominal visceral and subcutaneous fat areas, mid-thigh muscle attenuation and liver attenuation characteristics were determined; the mid-thigh muscle was divided into low-and normal-density muscle areas. Results: The young and middle-aged diabetic subjects had higher visceral fat areas, higher liver attenuation and higher lipid-rich muscle (greater low-density muscle area and decreased muscle attenuation) when compared with healthy individuals; however, no differences were observed between the two diabetic groups. In contrast, the C-IMT increased with both age and diabetes. On the basis of multiple regression analyses, mid-thigh low-density muscle area and muscle attenuation were independently associated with the C-IMT, and the mid-thigh normal-density muscle area and muscle attenuation were independent factors of insulin resistance. Conclusions: High fat stores within ectopic compartments were observed at an early stage in the development of diabetes. Furthermore, altered lipid partitioning within muscle was independently associated with carotid atherosclerosis and insulin resistance.

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“…The IMT was defined as the distance between the media-adventitia interface and the lumen-intima interface, and was measured in the 20 mm proximal to the origin of the carotid bulb using the IMT measurement software, Intimascope (Media Cross Co., Tokyo, Japan). 8 Average IMT was the mean value of 99 computer-based points in the region, and maximal IMT was the IMT value at a maximal point of the region. The same investigator performed all the ultrasonographic procedures used to estimate the abdominal adiposity and the IMT.…”

Section: Subjectsmentioning

confidence: 99%

Visceral fat amount is associated with carotid atherosclerosis even in type 2 diabetic men with a normal waist circumference

et al. 2008

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Objective: Our objective was to investigate whether determination of the quantity of visceral fat has an additional benefit in assessing atherosclerotic burden in men with type 2 diabetes compared with the traditional measurement of waist circumference (WC) alone. Methods: This was an observational study performed in 368 men with type 2 diabetes, consecutively enrolled in Diabetes Clinics. Common carotid artery far-wall intima-media thickness (IMT), WC and visceral fat thickness (VFT), as measured by ultrasonography, were measured for each subject. Abdominal and visceral obesity were defined as a WC 490 cm and a VFT X47.6 mm, respectively. Results: Among subjects with abdominal obesity (n ¼ 174), 35 subjects did not have visceral obesity. In contrast, among the subjects without abdominal obesity (n ¼ 194), 88 patients had visceral obesity. Despite no differences in age, glucose control, lipid profile and treatment modalities, there was a significant difference in carotid IMT based on VFT strata, but not WC strata. The subjects without abdominal obesity, but who had visceral obesity, had a higher carotid IMT compared with subjects with abdominal obesity, but without visceral obesity (maximal, 0.94 ± 0.35 vs 0.78 ± 0.17 mm; and average, 0.74 ± 0.19 vs 0.64 ± 0.14 mm, respectively, Po0.001). Conclusions: Subjects having visceral obesity, regardless of a normal WC, showed a higher carotid IMT compared with those with increased WC, but less visceral fat. In addition to WC, a direct estimation for visceral fat may provide an additional role in assessing atherosclerotic burden in men with type 2 diabetes.

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Evaluation of a New Carotid Intima-Media Thickness Measurement by B-Mode Ultrasonography Using an Innovative Measurement Software, Intimascope

Cited by 101 publications

References 23 publications

An integrated system for the complete segmentation of the common carotid artery bifurcation in ultrasound images

An integrated system for the complete segmentation of the common carotid artery bifurcation in ultrasound images

High fat stores in ectopic compartments in men with newly diagnosed type 2 diabetes: an anthropometric determinant of carotid atherosclerosis and insulin resistance

Visceral fat amount is associated with carotid atherosclerosis even in type 2 diabetic men with a normal waist circumference

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