Evaluation of a new multipurpose whole-body CzT-based camera: comparison with a dual-head Anger camera and first clinical images

Abstract

Background: Evaluate the physical performance of the VERITON CzT camera (Spectrum Dynamics, Caesarea, Israel) that benefits from new detection architecture enabling whole-body imaging compared to that of a conventional dual-head Anger camera. Methods: Different line sources and phantom measurements were performed on each system to evaluate spatial resolution, sensitivity, energy resolution and image quality with acquisition and reconstruction parameters similar to those used in clinical routine. Extrinsic resolution was assessed using 99m Tc capillary sources placed successively in air, in a head and in a body phantom filled with background activity. Spectral acquisitions for various radioelements used in nuclear medicine (99m Tc, 123 I, 201 Tl, 111 In) were performed to evaluate energy resolution by computing the FWHM of the measured photoelectric peak. Tomographic sensitivity was calculated by recording the total number of counts detected during tomographic acquisition for a set of source geometries representative of different clinical situations. Sensitivity was also evaluated in focus mode for the CzT camera, which consisted of forcing detectors to collect data in a reduced field-of-view. Image quality was assessed with a Jaszczak phantom filled with 350 MBq of 99m Tc and scanned on each system with 30-,20-,10-and 5-min acquisition times.

Evaluation of the Spatial Resolution in Monte Carlo-Based Spect/Ct Reconstruction of 111in-Octreotide Images

“…Among the references, in this study, comparing 111 In-SPECT and 68 Ga-PET, only one ( 6 ) has reported the use of attenuation and PSF correction, remaining authors have not reported any corrections at all, indicating that many comparisons may not have been completely fair. Furthermore, the field of SPECT is developing with new camera designs ( 17 , 18 ) as well as improved reconstruction techniques. Based on the results in this study, a comparison between 68 Ga PET/CT and MC-based reconstruction of 111 In-octreotide SPECT/CT would be of interest to evaluate, both regarding image quality and diagnostic sensitivity.…”

Paediatric Molecular Radiotherapy: Challenges and Opportunities

“…As patients will probably have multiple 123 I-mIBG scans, it is preferable to keep the cumulative dose as low as reasonably practicable in line with legislation. Perhaps, the future lies in better detector architecture [53].…”

SPECT/CT: Standing on the Shoulders of Giants, It Is Time to Reach for the Sky!

“…At present, this technology is being incorporated into general-purpose dual-and multihead SPECT/CT system designs ( Fig. 4) (35,36). Most importantly, reducing image acquisition times and lowering the injected radionuclide activity are now possible for cardiac studies (37) and are being explored for a wider range of nuclear medicine studies.…”

“…A true paradigm shift in SPECT/CT design was unveiled in 2017, when the first 360°ring-shaped gantry was introduced, equipped with 12 CZT-based elongated detectors that can move inward and outward to come as close to the patient as possible. These detectors are equipped with novel tungsten parallel-hole collimators and move in a swiveling motion to provide a unique scanning geometry (35). Although the clinical experience with this new device is still limited and the additional cost associated with this new design remains to be justified, preliminary results in bone imaging show that a whole-body SPECT acquisition of 20 min offers significant improvements in sharpness and contrast and can replace current bone-scanning protocols (40).…”